Are predictive factors in sperm retrieval and pregnancy rates present in nonobstructive azoospermia patients by microdissection testicular sperm extraction on testicle with a history of orchidopexy operation?

Abstract

The aim in this study is to evaluate predictive factors on sperm retrieval and pregnancy rates by microdissection testicular sperm extraction in non obstructive azoospermia patients with a history of orchidopexy operation. A total of 148 patients were included, and their medical files were evaluated. Data related to possible predictive factors on sperm retrieval and pregnancy rates such as age at orchidopexy operation, unilateral or bilateral presence of undescended testis before orchidopexy, testis volumes and hormone levels were statistically analysed. It revealed that the mean ages in patients with unilateral and bilateral orchidopexy operations were 35.37 (±4.84) and 33.94 (±5.91) respectively. Mean testis volume in the unilateral orchidopexy group was 7.59 (±3.12) ml on the right testis and 7.37 (±2.86) ml on the left testis. Mean FSH levels were detected as 22.71 (±11.86) mIU/ml in the unilateral group and 28.19 (±12.40) mIU/ml in the bilateral group. In our study, we have shown that the age at which patients undergo orchidopexy and the unilateral or bilateral presence of cryptorchidism has no correlation with sperm retrieval and pregnancy rates.

Fertility outcomes and predictors for successful sperm retrieval and pregnancy in 327 azoospermic men with a history of cryptorchidism who underwent microdissection testicular sperm extraction

“…Ozan et al showed a pregnancy rate of 28% after ICSI in accordance with the literature. They also demonstrated that the age at which patients underwent orchidopexy and the side on which cryptorchidism occurred had no significant effect on pregnancy rates after ICSI 9 . In the present study, younger male and female ages, and higher fertilization rates were the parameters that might predict pregnancy.…”

“…9 They found sperm retrieval rate as 60%, and age at orchidopexy and the unilateral or bilateral presence of cryptorchidism have no correlation with sperm retrieval and pregnancy rates after the TESE. 9 In our series, younger male and female ages and higher fertilization rates were the parameters that might predict pregnancy. Laterality of the undescended testes (unilateral: 56.8% versus bilateral: 50.5%) did not differ in terms of pregnancy rate.…”

“…To predict the success rate of TESE procedure, Ozan et al included 148 azoospermic men who underwent orchidopexy 9 . They found sperm retrieval rate as 60%, and age at orchidopexy and the unilateral or bilateral presence of cryptorchidism have no correlation with sperm retrieval and pregnancy rates after the TESE 9 .…”

“…Testicular sperm retrieval rates have been reported as 49.5 to 74% in azoospermic men with a history of cryptorchidism/orchidopexy. [3][4][5][6][7][8][9] Sperm retrieval rate has been significantly higher in azoospermic patients with a history of cryptorchidism than patients with different etiologies of non-obstructive azoospermia. fertilization, pregnancy, and live birth rates were similar between the two groups.…”

“…Testicular sperm retrieval rates have been reported as 49.5 to 74% in azoospermic men with a history of cryptorchidism or orchidopexy, and some studies have attempted to identify predictors for successful sperm retrieval in this population. [3][4][5][6][7][8][9] However, no study has reported risk factors that might predict sperm retrieval and pregnancy in azoospermic men with a history of cryptorchidism in a large series.…”