Are Russian propolis ethanol extracts the future for the prevention of medical and biomedical implant contaminations?

Ambi, Ashwin; Bryan, Julia; Borbon, Katherine; Centeno, Daniel; Liu, Tianchi; Chen, Tung Po; Cattabiani, Thomas; Traba, Christian

doi:10.1016/j.phymed.2017.03.006

Cited by 23 publications

(29 citation statements)

References 32 publications

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“…Likewise, metals could form a strong ligand complex with flavonoids and enhance the bactericidal activity of these complexes. Even though the metal composition of propolis samples has been hardly studied, the toxicity of propolis has been occasionally attributed to its heavy metal content [28]. The results here obtained through X-ray fluorescence spectrometry revealed that SEEP contains negligible traces of K, P, Zn and Cu (Table 3), and toxic metal compounds, such as Pb, Cr or Cd, were not detected at all.…”

Section: Rangementioning

confidence: 65%

“…Similar to other types of propolis samples, flavonoids, phenolic acids, lignans and a few other different kinds of polyphenols have also been identified in SEEP [ 8 , 28 ]. Remarkably, Ferulic acid, Vanillic acid, 1-Acetoxypinoresinol (lignan), p -HPEA-EA (ligstroside derivative) and 3,4-DHPEA-EA (oleuperin derivative), and Vanillin (phenolic aldehyde) are all found in commercial virgin olive oils [ 29 , 30 , 31 , 32 ], together with p -coumaric acid, caffeic acid, luteolin, apigenin and a few other minor phenolic compounds.…”

Section: Resultsmentioning

confidence: 95%

“…It has also been reported that it can selectively inhibit the growth of pathogenic bacteria without affecting the viability of probiotics [40]. Moreoever, the measured concentration of ferulic acid (4-hydroxy-3-methoxy-cinnamic acid) is higher than that found, for example, in Russian [28] or Greek propolis [41], and within in the concentrations range found in other Spanish propolis [18]. Importantly, the ferulic acid is a phenolic compound with important antioxidant effects which may offer beneficial effects against cancer, cardiovascular disease, diabetes and Alzheimer's disease [42].…”

Section: Quantification Of Marker and Metal Compoundsmentioning

confidence: 89%

“…The quantification of marker compounds was conducted following the method described by Ambi et al [28], with some modifications. The standards compounds (Vanillic acid, trans-Ferulic acid and Quercetin) were purchased from Sigma (Sigma, St. Louis, MO, USA.)…”

Section: Quantification Of Marker Compoundsmentioning

confidence: 99%

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Chemical Profile and Antibacterial Activity of a Novel Spanish Propolis with New Polyphenols also Found in Olive Oil and High Amounts of Flavonoids

et al. 2020

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Propolis is a natural product obtained from hives. Its chemical composition varies depending on the flora of its surroundings, but nevertheless, common for all types of propolis, they all exhibit remarkable biological activities. The aim of this study was to investigate the chemical composition and antimicrobial activity of a novel Spanish Ethanolic Extract of Propolis (SEEP). It was found that this new SEEP contains high amounts of polyphenols (205 ± 34 mg GAE/g), with unusually more than half of this of the flavonoid class (127 ± 19 mg QE/g). Moreover, a detailed analysis of its chemical composition revealed the presence of olive oil compounds (Vanillic acid, 1-Acetoxypinoresinol, p-HPEA-EA and 3,4-DHPEA-EDA) never detected before in propolis samples. Additionally, relatively high amounts of ferulic acid and quercetin were distinguished, both known for their important therapeutic benefits. Regarding the antimicrobial properties of SEEP, the minimal inhibitory and bactericidal concentrations (MIC and MBC) against Staphylococcus epidermidis strains were found at the concentrations of 240 and 480 µg/mL, respectively. Importantly, subinhibitory concentrations were also found to significantly decrease bacterial growth. Therefore, the results presented here uncover a new type of propolis rich in flavonoids with promising potential uses in different areas of human health.

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Section: Rangementioning

confidence: 65%

Section: Resultsmentioning

confidence: 95%

Section: Quantification Of Marker and Metal Compoundsmentioning

confidence: 89%

Section: Quantification Of Marker Compoundsmentioning

confidence: 99%

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Chemical Profile and Antibacterial Activity of a Novel Spanish Propolis with New Polyphenols also Found in Olive Oil and High Amounts of Flavonoids

et al. 2020

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“…The action of artepillin C may occur due to its binding to the complex mortalin‐p53, inducing p53 activation (Bhargava et al, ). Ambi et al () associated the presence of flavonoids and phenolic acids to the cytotoxic action of Russian propolis against murine osteoblasts (MC‐3 T3). Flavonoids seemed also to be involved in the cytotoxic action of a Brazilian propolis sample collected in Bahia State (Mitsui et al, ) and in the Lebanese propolis (Noureddine et al, ).…”

Section: Discussionmentioning

confidence: 99%

The chemical composition and events related to the cytotoxic effects of propolis on osteosarcoma cells: A comparative assessment of Colombian samples

Mora

Santiago

Conti

et al. 2018

Phytotherapy Research

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Osteosarcoma (OSA) is a type of bone cancer showing an aggressive biological behavior with metastatic progression. Because propolis potential for the development of new antitumoral drugs has been indicated, we evaluated the chemical composition of Colombian propolis samples and the mechanisms involved in their cytotoxic effects on OSA cells. The chemical composition was analyzed by GC–MS and the DPPH free radical scavenging activity was measured. Cluster and principal components analysis were used to establish an association with their inhibitory concentration 50% (IC50). Cell viability was analyzed by MTT assay; apoptosis was determined by flow cytometry; mitochondrial membrane permeability and reactive oxygen species were evaluated by rhodamine 123 and DCFH‐DA. Transwell assay was used to evaluate the invasiveness of propolis‐treated cells. Samples were grouped: Cluster 1 contained diterpenes and benzophenones and showed the highest antiradical activity; Cluster 2 was characterized by triterpenes, fatty acid, and diterpenes. Usm contained diterpenes and triterpenes different of the other samples and Sil contained triterpenes and flavonoids. Apoptosis, mitochondrial membrane alteration, and suppression of cell invasion were the main mechanisms involved in the inhibition of OSA cells in vitro, suggesting the potential of Colombian propolis to discover new antitumor drugs.

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Chemical characterization and cytotoxic activity evaluation of Lebanese propolis

Noureddine

Hage‐Sleiman

Wehbi

et al. 2017

Biomedicine & Pharmacotherapy

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Are Russian propolis ethanol extracts the future for the prevention of medical and biomedical implant contaminations?

Cited by 23 publications

References 32 publications

Chemical Profile and Antibacterial Activity of a Novel Spanish Propolis with New Polyphenols also Found in Olive Oil and High Amounts of Flavonoids

Chemical Profile and Antibacterial Activity of a Novel Spanish Propolis with New Polyphenols also Found in Olive Oil and High Amounts of Flavonoids

The chemical composition and events related to the cytotoxic effects of propolis on osteosarcoma cells: A comparative assessment of Colombian samples

Chemical characterization and cytotoxic activity evaluation of Lebanese propolis

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