Are saturated fatty acids and insulin resistance associated with fatty liver in obese children?

Papandreou, Dimitrios; Rousso, Israel; Malindretos, Pavlos; Makedou, Areti; Moudiou, Tatiana; Pidonia, Ifigenia; Pantoleon, Athina; Economou, Ipolliti; Mavromichalis, I.

doi:10.1016/j.clnu.2007.11.003

Cited by 17 publications

(21 citation statements)

References 44 publications

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“…Each box-plot represents the median (thick black band) and the 25th and 75th centiles by Doppler US. The prevalence of FLD varied between 12% and 80% using B-mode US in other studies [8,25]. Abnormal Doppler waveform was detected in two third of FL patients identified by B-mode US.…”

Section: Discussionmentioning

confidence: 88%

Metabolic predictors for early identification of fatty liver using doppler and B-mode ultrasonography in overweight and obese adolescents

et al. 2010

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(1) to evaluate the frequency of asymptomatic fatty liver disease (FLD) using both Doppler and B-mode ultrasound (US) in overweight and obese adolescents; (2) to compare metabolic findings of fatty liver (FL) assessed by two methods; and (3) to evaluate metabolic predictors of FL shown by these methods. Fifty-nine overweight and obese adolescents aged between 9.0 and 17.0 years and 41 non-obese healthy adolescents were included in this study. B-mode and right hepatic vein Doppler ultrasonography (US) were performed and anthropometric indices, lipid profiles, and adiponectin levels were evaluated in all adolescents. HDL-C levels were significantly lower in patients with FL detected by Doppler US compared to patients without FL (p < 0.05). HDL-C levels were inversely correlated with presence of FL assessed by two methods (r = -0.285, p = 0.004; r = -0.328, p = 0.001, respectively) and adiponectin levels were correlated with presence of FL only detected by B-mode US (r = -0.263, p = 0.008). Adiponectin levels were significantly lower in patients with FL than those without FL assessed by B-Mode US (p = 0.049). Multiple regression analysis revealed that HDL-C levels was the most important predictor of FL assessed by Doppler US (p = 0.027), while body mass index was the determinant of FL assessed by two methods (p < 0.001) in asymptomatic overweight and obese adolescents. It was found that FLD, identified by both B-mode and Doppler US, is seen frequently in asymptomatic overweight and obese adolescents. Elevated BMI is associated with increased risk of FL assessed by two ultrasonographic methods. When using Doppler US, low HDL-C levels can be used as a good predictor for presence of FLD in overweight and obese adolescents.

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Section: Discussionmentioning

confidence: 88%

Metabolic predictors for early identification of fatty liver using doppler and B-mode ultrasonography in overweight and obese adolescents

et al. 2010

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“…Schwimmer et al (16) reported that 88% of 43 children who were diagnosed as NFLD with biopsy were found to be obese. Papandreou et al (17) reported that they found steatosis in 42% of obese children on USG. In another study, 90% of individuals who were found to have NFLD/SH by biopsy were overweight or obese and especially abdominal obesity affected NFLD (8).…”

Section: Discussionmentioning

confidence: 99%

Şişman çocuk ve ergenlerde alkolik olmayan yağlı karaciğer hastalığı

...

2012

Tpa

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Aim:To determine the prevelance of the non-alcoholic fatty liver in obese children. Material and Method: Medical records of 161 obese children (age 4-18 yrs) who were investigated for non-alcoholic fatty liver by USG were analysed retrospectively. Their findings of physical examination and antropometric measurements, presence of acanthosis nigricans, pubertal status and results of laboratory analysis were evaluated. The study protocol was approved by the Osmangazi University Ethical Committee (2010/13). Results: Hepatosteatosis was found in 40% of the patients by ultrasonography. Elevation of serum alanine aminotransferase (≥40 U/L) was found in 35% of the patients with steatosis. These patients had higher body mass index, HOMA-IR (Homeostasis model of assessment-insulin resistance) and aspartat aminotransferase, alanine aminotransferase, insulin and triglyceride levels and lower HDL-C levels and higher acanthosis nigricans prevalences than the patients without steatosis. Patients with elevated alanine aminotransferase levels had significantly higher trygliceride and lower HDL-C levels than the patients with normal alanine aminotransferase levels. Steatosis prevalences were 32% in girls and 54% in boys (p<0.01). The prevalence of elevated alanine aminotransferase was found higher in prepubertal children (p<0.05), but, the steatosis prevalences were not different between prepubertal-pubertal children and between prepubertal girls and boys. Pubertal boys had higher steatosis prevalence than pubertal girls (p<0.05). The prevalence of steatosis was higher in children with acanthosis nigricans (p=0.001). The prevalences of steatosis and elevated alanine aminotransferase levels were not different between children with and without insulin resistance. In a logistic regression model, sex, body mass index and HDL-C were the determinants of steatosis and only HDL-C were related with alanine aminotransferase levels. Conclusions: High prevalences of hepatosteatosis and elevated alanine aminotransferase levels are found in obese children and adolescents. Gender, the degree of obesity and dyslipidemia are more important determinants of steatosis than insulin resistance. (Turk Arch Ped 2012; 47: 172-178)

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“…78,79,81,87 Increased consumption of fiber may be beneficial in displacement of simple dietary carbohydrates and improving the gut microbiome.…”

Section: Pre-and Probioticsmentioning

confidence: 99%

“…On examining 3-day diet records, Papandreou et al 81 reported that in a cohort of 43 obese children, there were no differences in energy (2435 vs 2815 kcal; P = .658), fat (123 vs 140.4 g; P = .664), or protein (95.2 vs 116.3 g; P = .322) intake between children with mild or moderate to severe NAFLD and obese children who did not have NAFLD. The intake of carbohydrate (268.9 vs 278.2 g; P = .001) and sugar (18.6 vs 22.9 g; P = .001) was significantly increased in the obese children with NAFLD compared with those without NAFLD.…”

Section: Fat/saturated Fat/polyunsaturated Fatmentioning

confidence: 99%

“…[78][79][80] Conversely, obese children screened for parameters of NAFLD did not demonstrate differences in vitamin E consumption among the children without hepatic steatosis, mild hepatic steatosis, and moderate/severe hepatic steatosis. 81 Other agents currently under investigation for the treatment of pediatric NAFLD include the TNF-α inhibitor pentoxifylline. More research is needed to make any recommendations at this time.…”

Section: Vitamin Ementioning

confidence: 99%

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