Are the new microfertilization techniques associated with an increased genetic risk to the offspring?

Lundin, Kersti; Hanson, Charles; Hamberger, Lars

doi:10.1034/j.1600-0412.1998.770802.x

Cited by 4 publications

(1 citation statement)

References 43 publications

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“…We would point out that PGD is a relatively new technique, at an early state of clinical use. There may be unknown future risks due to the IVF/ICSI/ biopsy techniques (23)(24)(25) and PGD must therefore be used with care.…”

Section: Discussionmentioning

confidence: 99%

Preimplantation genetic diagnosis (PGD): The Gothenburg experience

Hanson¹,

Jakobsson²,

Sjögren³

et al. 2001

Acta Obstet Gynecol Scand

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Successful PGD in its clinical application demands close collaboration between a large group of specialists. Even so, the success rate is considerably lower than after conventional IVF or ICSI procedures. Taking into account the stress caused to the parents facing late interruption of pregnancy following conventional prenatal diagnosis we are convinced that this technique is well worthwhile continuing and refining.

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Section: Discussionmentioning

confidence: 99%

Preimplantation genetic diagnosis (PGD): The Gothenburg experience

Hanson¹,

Jakobsson²,

Sjögren³

et al. 2001

Acta Obstet Gynecol Scand

Self Cite

View full text Add to dashboard Cite

show abstract

Preimplantation genetic diagnosis (PGD): The Gothenburg experience

Hanson¹,

Jakobsson

Sjögren³

et al. 2001

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

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Diagnostic epididymal and testicular sperm recovery and genetic aspects in azoospermic men

Westlander

1999

Human Reproduction

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Various procedures for sperm recovery in azoospermic men have been described, from open testicular biopsy to simple needle aspiration from the epididymis and the testis. Fifty-one obstructive and 86 non-obstructive azoospermic men were treated to compare the recovery of spermatozoa obtained by percutaneous aspiration from the epididymis (PESA) and aspiration/extraction from the testis (TESA, TESE) with histopathology. If TESA failed, the work up proceeded with TESE. All patients were karyotyped. Spermatozoa were recovered by PESA or TESA in all obstructive men (51/51 patients). In 22 out of 86 patients with non-obstructive azoospermia, testicular spermatozoa could be successfully recovered by TESA. In five additional patients TESE was successful in recovering spermatozoa where TESA had failed. In 43 patients, neither TESA nor TESE was successful. Sixteen patients chose not to proceed with TESE. Seven out of 86 patients had an abnormal karyotype in the non-obstructive group (8%), none in the obstructive group. In the non-obstructive patient group testicular histopathology showed hypospermatogenesis, incomplete maturation arrest and germ cell aplasia with focal spermatogenesis in cases where spermatozoa were recovered and complete germ cell aplasia, complete maturation arrest and fibrosis in cases where no spermatozoa were found. Spermatozoa were recovered by PESA or TESA from all patients with obstructive azoospermia and from approximately 40% of patients with non-obstructive azoospermia by TESA or TESE. Retrieval of viable spermatozoa in the infertility work-up was highly predictable for sperm recovery in subsequent ICSI cycles. TESA performed under local anaesthesia seems almost as effective as more invasive procedures in recovering testicular spermatozoa, both in obstructive and non-obstructive azoospermic men.

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Are the new microfertilization techniques associated with an increased genetic risk to the offspring?

Cited by 4 publications

References 43 publications

Preimplantation genetic diagnosis (PGD): The Gothenburg experience

Preimplantation genetic diagnosis (PGD): The Gothenburg experience

Preimplantation genetic diagnosis (PGD): The Gothenburg experience

Diagnostic epididymal and testicular sperm recovery and genetic aspects in azoospermic men

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