2011
DOI: 10.1016/j.jep.2011.10.018
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Are there new therapeutic options for treating lung cancer based on herbal medicines and their metabolites?

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Cited by 56 publications
(33 citation statements)
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“…The main mechanism of MDR involves overproduction of P-glycoprotein (P-gp), a member of membrane-bound ATP-binding cassette (Jeong et al, 2011). It can transport intracellular drug outside the cell by active ATP pump, leading to weakened effect of drug resulting in MDR.…”
Section: Synergies With Chemotherapy and Reduced Resistance To Chemotmentioning
confidence: 99%
“…The main mechanism of MDR involves overproduction of P-glycoprotein (P-gp), a member of membrane-bound ATP-binding cassette (Jeong et al, 2011). It can transport intracellular drug outside the cell by active ATP pump, leading to weakened effect of drug resulting in MDR.…”
Section: Synergies With Chemotherapy and Reduced Resistance To Chemotmentioning
confidence: 99%
“…10 The angiogenesis-and metastasis-related factors such as VEGF and MMPs, along with cell proliferation-and survival-related factors such as Akt, NF-κB, Ras, MAPKs, and EGFR, are importantly considered as target molecules for lung cancer therapy. 11 Although it is hard to identify with assurance, cancer preventive compounds in fruits and vegetables, experimental data, and human observational studies showing the protective effects of major nutritional antioxidants prompted five large intervention trials to be initiated in the 1990s to determine the potential of specific antioxidant supplements in reducing cancer risk. A study in China, the United States, and Finland tested the protective effects of various combined micronutrients ( vitamin E, vitamin A, and β-carotene) in various combinations on reducing lung cancer risk in smokers and non-smokers.…”
Section: Role Of Fruits and Vegetables In The Prevention Of Lung Cancermentioning
confidence: 99%
“…In Asia, PSK is used as an anti-cancer agent for gastric cancer, 9 induction the apoptosis of human leukemia and lymphoma cells, 5 colorectal cancers, 9,10 and small cell lung cancer. 11 PSK has also been reported to resolve the immunosuppressive state of a cancer-bearing host, 12 and might be associated with DC maturation directly. [13][14][15] However, there was no report so far, on the maturation of morphology, phenotype and functions of the BMDCs induced by PSK, and related mechanisms at molecular level.…”
Section: Maturation Of Morphology Phenotype and Functions Of Murine mentioning
confidence: 99%