Are We Ill Because We Age?

Fülöp, Tamás; Larbi, Anis; Khalil, Abdelouahed; Cohen, Alan A.; Witkowski, Jacek M.

doi:10.3389/fphys.2019.01508

Cited by 55 publications

(36 citation statements)

References 128 publications

(143 reference statements)

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“…Over 300 definitions try to explain what aging means [4]. One view is that biological aging is the process of a change in the organism, which over time decreases the probability of survival and reduces the physiological capacity for self-regulation, self-repair, and adaptation to environmental demands.…”

Section: Is Kidney Aging a "Treatable" Condition?mentioning

confidence: 99%

“…Chronic noncommunicable diseases, such as cardiovascular diseases and cancer, cause most of the burden. Therefore, increased life expectancy is not only seen positively, and the terms "grey-tsunami" or "silver-tsunami" compile the fear that an increased aging society may overwhelm the social and health systems [4]. In the last decade, many efforts have been put to understand how to promote healthy aging [5].…”

Section: Introductionmentioning

confidence: 99%

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Phosphate and Kidney Healthy Aging

Rubio‐Aliaga

2020

Kidney Blood Press Res

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Background: The aging population is increasing rapidly, much faster than our understanding on how to promote healthy aging free of multimorbidities. The aging kidney shows a decline in its function. Whether this decline is preventable or physiological is still debated. Main risks factors for developing CKD are aging common comorbidites, such as hypertension, diabetes, and obesity. Phosphate is vital for our organism, but it is also present in a great variety of food products as food additive and preservative. Due to the higher consumption of processed food in the last century, concern has arisen if a chronic high consumption of phosphate may be toxic impacting on healthy aging. Summary: Several studies show an association between higher serum phosphate levels and a higher risk of overall mortality and cardiovascular disease. Moreover, higher phosphate levels also worsen CKD progression and may contribute to renal dysfunction in healthy individuals. Acute high phosphate intake is rare but can cause acute kidney injury. Yet, the question if controlling phosphate intake may modulate serum phosphate concentrations remains unanswered, as assessment of phosphate intake is still a difficult task. Phosphate consumption estimations by dietary recalls are largely underestimated, especially in populations groups consuming high amount of processed food. Key Message: A healthy diet with phosphate source from food may contribute to promote healthy aging and longevity.

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Section: Is Kidney Aging a "Treatable" Condition?mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phosphate and Kidney Healthy Aging

Rubio‐Aliaga

2020

Kidney Blood Press Res

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“…Much of this literature characterizes ageing as a disease that can theoretically be cured, or at least delayed [11][12][13][14][15][16]. However, a number of prominent researchers have argued for a change in perspective to distinguish the process of ageing from the diseases that are affected by age [17][18][19]. This evolutionarily guided perspective acknowledges that for most species, ageing is a natural and inevitable feature of life.…”

Section: An Evolutionary Approach To Ageingmentioning

confidence: 99%

Insights from evolutionarily relevant models for human ageing

Thompson

Rosati

Snyder‐Mackler

2020

Phil. Trans. R. Soc. B

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As the world confronts the health challenges of an ageing population, there has been dramatically increased interest in the science of ageing. This research has overwhelmingly focused on age-related disease, particularly in industrialized human populations and short-lived laboratory animal models. However, it has become clear that humans and long-lived primates age differently than many typical model organisms, and that many of the diseases causing death and disability in the developed world are greatly exacerbated by modern lifestyles. As such, research on how the human ageing process evolved is vital to understanding the origins of prolonged human lifespan and factors increasing vulnerability to degenerative disease. In this issue, we highlight emerging comparative research on primates, highlighting the physical, physiological, behavioural and cognitive processes of ageing. This work comprises data and theory on non-human primates, as well as under-represented data on humans living in small-scale societies, which help elucidate how environment shapes senescence. Component papers address (i) the critical processes that comprise senescence in long-lived primates; (ii) the social, ecological or individual characteristics that predict variation in the pace of ageing; and (iii) the complicated relationship between ageing trajectories and disease outcomes. Collectively, this work provides essential comparative, evolutionary data on ageing and demonstrates its unique potential to inform our understanding of the human ageing process. This article is part of the theme issue ‘Evolution of the primate ageing process’.

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“…The ageing process in humans encompasses many changes that ultimately lead to undesirable clinical conditions like a higher fat deposition, osteoporosis, sarcopenia, frailty, and physical disability [ 1 , 2 ]. Current research on ageing focuses on decreasing the risk of developing the previously mentioned conditions and designing effective interventions to improve the patient’s health [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Protein Intake Patterns and Inadequate Protein Intake in Older Adults from Four Countries

Gaytán-González

Ocampo-Alfaro²,

Torres-Naranjo

et al. 2020

Nutrients

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Recent interest in protein intake per meal is observed in studies that have reported the protein intake patterns in different countries; however, comparisons of these data are lacking. We aimed to compare protein intake patterns and the percentage of inadequate protein intake (IPI) per day and meal in older adults from different countries. We acquired data of protein intake in older adults from four countries (Mexico, United States of America, Germany, and United Kingdom). We compared protein intake (per day and meal), IPI per day and meal, and the number of meals with an adequate protein content among countries. The IPI per day significantly differed among countries for <0.8 and <1.0 (both p < 0.001), but not for <1.2 g/kg/d (p = 0.135). IPI per meal (<30 g/meal) did not differ among countries at breakfast (p = 0.287) and lunch (p = 0.076) but did differ at dinner (p < 0.001). Conversely, IPI per meal (<0.4 g/kg/meal) significantly differed among countries at breakfast, lunch, and dinner (all p < 0.001). The percentage of participants that ate ≥30 g/meal or ≥0.4 g/kg/meal at zero, one, and two or three meals per day significantly differed among countries (all p < 0.05). IPI at breakfast and lunch (<30 g/meal) was a common trait in the analyzed samples and might represent an opportunity for nutritional interventions in older adults in different countries.

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Are We Ill Because We Age?

Cited by 55 publications

References 128 publications

Phosphate and Kidney Healthy Aging

Phosphate and Kidney Healthy Aging

Insights from evolutionarily relevant models for human ageing

Dietary Protein Intake Patterns and Inadequate Protein Intake in Older Adults from Four Countries

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