2024
DOI: 10.3389/frhem.2024.1407698
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Are we ready to integrate 3D culture systems in acute myeloid leukemia and bone marrow microenvironment research?

Azmeer Sharipol,
Benjamin J. Frisch

Abstract: Acute myeloid leukemia (AML) is the most aggressive adult leukemia and results in a dismal 5-year survival rate of less than 30%. While research has primarily focused on identifying intrinsic mutations driving leukemogenesis, the role of the bone marrow microenvironment (BMME) in disease progression remains poorly understood. For this purpose, conventional 2D cultures inadequately replicate the complex BMME interactions crucial for the maintenance of normal hematopoiesis and leukemia pathogenesis. In recent ye… Show more

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