Are we ready to predict and prevent endocrine/organ specific autoimmune diseases?

Seißler, Jochen; Scherbaum, Werner A.

doi:10.1007/s00281-002-0113-z

Cited by 17 publications

(27 citation statements)

References 160 publications

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“…This is best predicted when autoantibodies to different autoantigens are already present in the preclinical phase (9). Type I diabetes is one such example and best studied in this context.…”

Section: Speciesmentioning

confidence: 99%

“…Type I diabetes is one such example and best studied in this context. The presence of autoantibodies against three different autoantigens, the 65-kDa isoform of glutamate decarboxylase (GAD65), tyrosine phosphatase IA-2, and insulin, represents a positive predictive value for developing diabetes between 46 and 80% in the general population that increases to 100% in first degree relatives (9). Additional studies indicate the effectiveness of a populationbased diabetes screening (16,30,31), and a placebo controlled study is underway testing nasal tolerance induction to insulin in islet cell antibody-positive children (32).…”

Section: Speciesmentioning

confidence: 99%

“…Intermolecular reaction patterns underline the necessity to identify the complete arrangement of individual participating autoantigens (9).…”

Section: Speciesmentioning

confidence: 99%

“…Investigation of a number of autoantigens in type I diabetes has shown that the three major islet autoantigens are most relevant for diagnosis and prediction (9). Because cRALBP autoantibodies have been shown in some control horses, we plan to extend these observations for several years because multiple reports have demonstrated the considerable value of autoantibodies for disease prediction, even in T cell-mediated autoimmune diseases (9,13,34). In addition, it has also been reported that the autoimmune process precedes overt clinical symptoms for many months or years (9).…”

Section: Speciesmentioning

confidence: 99%

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Identification and Functional Validation of Novel Autoantigens in Equine Uveitis

Deeg

Pompetzki

Raith

et al. 2006

Molecular & Cellular Proteomics

137

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The development, progression, and recurrence of autoimmune diseases are frequently driven by a group of participatory autoantigens. We identified and characterized novel autoantigens by analyzing the autoantibody binding pattern from horses affected by spontaneous equine recurrent uveitis to the retinal proteome. Cellular retinaldehyde-binding protein (cRALBP) had not been described previously as autoantigen, but subsequent characterization in equine recurrent uveitis horses revealed B and T cell autoreactivity to this protein and established a link to epitope spreading. We further immunized healthy rats and horses with cRALBP and observed uveitis in both species with typical tissue lesions at cRALBP expression sites.

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Section: Speciesmentioning

confidence: 99%

Section: Speciesmentioning

confidence: 99%

“…Intermolecular reaction patterns underline the necessity to identify the complete arrangement of individual participating autoantigens (9).…”

Section: Speciesmentioning

confidence: 99%

Section: Speciesmentioning

confidence: 99%

See 2 more Smart Citations

Identification and Functional Validation of Novel Autoantigens in Equine Uveitis

Deeg

Pompetzki

Raith

et al. 2006

Molecular & Cellular Proteomics

137

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show abstract

“…In NOD mice several immunosuppressive regimens have been shown to provide some protection from diabetes [25,26]. However, it is clear that an islet cell-or autoantigen-specific immunomodulation is the approach of choice with regard to human Type 1 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Autoantigen-specific protection of non-obese diabetic mice from cyclophosphamide-accelerated diabetes by vaccination with dendritic cells

et al. 2003

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Aims/hypothesis. Dendritic cells (DCs) are professional antigen presenting cells involved in the initiation of primary immune responses and the preservation of peripheral tolerance. The aim of this study was to develop a DC vaccine for autoantigen-specific prevention of autoimmune diabetes. Methods. Splenocytes from diabetes-prone NOD mice were cultured in conditioned media to obtain a homogeneous DC sub-population for vaccination experiments. These cells were used to modulate autoimmune responses in NOD mice after synchronization of diabetes with cyclophosphamide. After immunisation with insulin-pulsed DCs the incidence of diabetes, the insulitis grade and the cytokine production was examined. Results. The long-term culture of splenocytes resulted in the generation of a cell line, termed NOD-DC1, which have a phenotype of myeloid DCs (CD11c, CD11b, DEC-205), express MHC class II and costimulatory molecules (CD40, CD80, CD86). The NOD-DC1 cells have preserved functional activity shown by the detection of a high antigen uptake capacity, the induction of a mixed lymphocyte reaction and stimuli-dependent IL-6 and TNF-α secretion. Vaccination with insulin-pulsed NOD-DC1 cells results in an antigen-specific prevention of diabetes. This was mediated by a reduction of the severity of insulitis and a decrease of T helper 1 effector cells. Conclusion/interpretation. We describe the generation of a DC line which confers protection from diabetes in an antigen-specific way. Our data shows that autoantigen-loaded DCs can induce strong immunoregulatory effects supporting the hypothesis that DCs are promising candidates to develop novel vaccines for the prevention of autoimmune diabetes. [Diabetologia (2003[Diabetologia ( ) 46:1357[Diabetologia ( -1365

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Diseases of the uvea, uveitis, and recurrent uveitis

Gilger

Hollingsworth

2016

Equine Ophthalmology

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Are we ready to predict and prevent endocrine/organ specific autoimmune diseases?

Cited by 17 publications

References 160 publications

Identification and Functional Validation of Novel Autoantigens in Equine Uveitis

Identification and Functional Validation of Novel Autoantigens in Equine Uveitis

Autoantigen-specific protection of non-obese diabetic mice from cyclophosphamide-accelerated diabetes by vaccination with dendritic cells

Diseases of the uvea, uveitis, and recurrent uveitis

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