Area between the hepatic and heart curves of ^99mTc‐galactosyl‐human serum albumin scintigraphy represents liver function and disease progression for preoperative evaluation in hepatocellular carcinoma patients

Abstract

We have developed a novel liver function indicator, the ABC, to count radioactivity in sequence. The ABC reflects liver function according to pathological deterioration of the liver. Although the ABC gave no significant advantage compared to HH15 and LHL15, it improved the AUC evaluation by 0.028-0.034.

Impact of comorbid renal dysfunction in patients with hepatocellular carcinoma on long-term outcomes after curative resection

“…The diagnosis of HCC, disease progression and resectability status were assessed via general status, physical findings, serological tests, and imaging studies, including contrast-enhanced computed tomography, magnetic resonance imaging, and ultrasonography. Liver function was assessed with a blood liver function test, the Child-Pugh grade, the estimated indocyanine green retention rate at 15 min[ 15 , 16 ], and the technetium-99 m-galactosyl human serum albumin scintigraphy index[ 17 ]. To evaluate the feasibility of hepatectomy in HCC patients with RD, the primary endpoint of the present study was long-term outcomes [median survival time (MST)] after hepatectomy.…”

Primary ovarian insufficiency associated with lenvatinib therapy in a patient with hepatocellular carcinoma: A case report

“…Her Child-Pugh classification was A. 99mTc-labelled diethylene triamine pentaacetate-galactosyl-human serum albumin scintigraphy was performed before surgery (13). The radioactivity of the liver regions of interest (ROI) divided by that of the liver-plus-heart ROI at 15 min (LHL15) was 0.969, and radioactivity of the heart ROI at 15 min divided by that at 3 min (HH15) was 0.753, thus revealing no reduction in hepatic blood flow due to the tumor.…”