Area under the concentration curve values in pediatric liver transplant recipients on cyclosporin microemulsion formulation

Therapeutic drug monitoring of cyclosporin A: Should we use the area under the concentration–time curve and forget trough levels?

“…Dunn et al ( 19) reported a relationship between predose trough levels of CsA and AUC for Neoral in stable maintenance pediatric liver transplant recipients. He divided patients into two groups: the first comprising children under 7 yrs of age; and the second comprising children older than 7 yrs.…”