Areca Thirteen Pill Improves Depression in Rat by Modulation of the Chemokine/Chemokine Receptor Axis

Bai, Jing-jing; Ao, Min; Xing, An; Yu, Li-jun; Tong, Hai-ying; Bao, Wu-ye; Wang, Yu

doi:10.1007/s12035-023-03855-1

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…Areca nut has been used to treat depression for years in Mongolia, and there is a traditional Mongolian herbal formula containing areca nut called Areca Thirteen Pill, also named Gao You-13 (GY-13), which has an excellent anti-depression effect. GY-13 improves depression by modulating the chemokine/chemokine receptor axis [ 114 ]. Besides, this GY-13 can significantly restore the expression level of cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), brain-derived neurotrophic factor (BDNF), and cAMP response element binding (CREB), and increase the proliferative activity in the hippocampus, thereby improving depressive behaviors [ 115 ].…”

Section: Functional Effects Of Areca Nut Componentsmentioning

confidence: 99%

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Sun,

Yu,

et al. 2024

Nutrients

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Areca catechu L. is a widely cultivated tropical crop in Southeast Asia, and its fruit, areca nut, has been consumed as a traditional Chinese medicinal material for more than 10,000 years, although it has recently attracted widespread attention due to potential hazards. Areca nut holds a significant position in traditional medicine in many areas and ranks first among the four southern medicines in China. Numerous bioactive compounds have been identified in areca nuts, including alkaloids, polyphenols, polysaccharides, and fatty acids, which exhibit diverse bioactive functions, such as anti-bacterial, deworming, anti-viral, anti-oxidant, anti-inflammatory, and anti-tumor effects. Furthermore, they also display beneficial impacts targeting the nervous, digestive, and endocrine systems. This review summarizes the pharmacological functions and underlying mechanisms of the bioactive ingredients in areca nut. This helps to ascertain the beneficial components of areca nut, discover its medicinal potential, and guide the utilization of the areca nut.

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Section: Functional Effects Of Areca Nut Componentsmentioning

confidence: 99%

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Sun,

Yu,

et al. 2024

Nutrients

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Xiaoyaosan against depression through suppressing LPS mediated TLR4/NLRP3 signaling pathway in “microbiota-gut-brain” axis

Liu,

et al. 2024

Journal of Ethnopharmacology

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Areca Thirteen Pill Improves Depression in Rat by Modulation of the Chemokine/Chemokine Receptor Axis

Cited by 2 publications

References 41 publications

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

Xiaoyaosan against depression through suppressing LPS mediated TLR4/NLRP3 signaling pathway in “microbiota-gut-brain” axis

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