Arginin als Vorstufe von Galegin in Galega officinalis L. Zur Biochemie und Physiologie von Galegin in Galega officinalis L., III. Mitt.

Reuter, G.

doi:10.1002/ardp.19632960805

Cited by 18 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the Medieval period, it was used as a therapy for diabetes (20,22). One of the main components of G. officinalis is alkaloid galegine possessing hypoglycemic properties in animal models (23). Furthermore, it was shown that G. officinalis has a remarkable effect on body weight loss and insulin (24).…”

Section: Mortalities and Morbiditiesmentioning

confidence: 99%

The Effect of Galega officinalis on Hormonal and Metabolic Profile in a Rat Model of Polycystic Ovary Syndrome

Abtahi-Eivari¹,

Moghimian²,

Soltani³

et al. 2017

International Journal of Women’s Health and Reproduction Scienc

View full text Add to dashboard Cite

Introduction Polycystic ovary syndrome (PCOS) is considered as one of the current disorders of the endocrine system in women of reproductive age (1-3). The epidemiological studies indicated that the incidence of PCOS varies in the world with a range of 2.2% to 26% (2,4). Such incidence is 43% to 46% in the United States, 37.4% in Germany, and 16% in Italy (5). The typical complications of PCOS include polycystic ovaries, elevated luteinizing hormone, hyperandrogenism, chronic anovulation along with oligoamenorrhea, obesity, and infertility (6). PCOS could be taken into account as a metabolism-centered syndrome such as insulin resistance syndrome or some other risk factors, including cardiovascular diseases, hypertension, and/or dyslipidemia (7). Although the mechanism underlying the pathogenesis of PCOS is still elusive, this syndrome is concomitant with hormonal perturbation, such as a diminished concentration of progesterone and heightened levels of testosterone, estrogen and luteinizing hormone (8-10). In patients afflicted with both hyperandrogenism and PCOS, there is a strong association between the hyperinsulinemia and hyperandrogenism as the concentration of insulin shows a strong correlation with adrenal steroid excretion (11). On the other hand, in patients with PCOS, hyperinsulinemia is concurrent with heightened levels of low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), triglyceride, total cholesterol (12) and reduced level of high-density lipoproteins (HDL) (13). Additionally, besides insulin resistance, the metabolism of lipid in females suffered from PCOS may be altered by ovarian-or adrenalexcretion of sex steroid hormones. Effects of sex steroids Abstract Objectives: Polycystic ovary syndrome (PCOS) has been considered as one of the most common endocrine diseases among the females in their regenerative age with a prevalence range of 5 to 21%. However, the purpose of the present study was to investigate the protective effect of Galega officinalis on metabolic as well as hormonal parameters in a rodent model of PCOS. Materials and Methods: Thirty-two Wistar female rats were used (n=8/group) in the study consisting of healthy control and experimental groups. The experimental groups were divided into 3 subgroups, including rats with PCOS which received no treatment (G1), PCOS group in which G. officinalis extract was administered daily at a dose of 200 mg/kg/orally (G2) for 2 weeks, and PCOS group in which G. officinalis extract was administered daily at a dose of 400 mg/kg/orally (G3) for 2 weeks. In all experimental groups, a single intramuscular injection of estradiol valerate led to inducing PCOS. After the end of treatment period, rats in all of the studied groups were anesthetized with ketamine/xylazine (5/1 mg/kg), then the blood samples obtained and their serum samples were applied for testing the fasting blood sugar (FBS), insulin, aromatase, and follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and estrogen. The ovaries of rats were removed and fi...

show abstract

Section: Mortalities and Morbiditiesmentioning

confidence: 99%

The Effect of Galega officinalis on Hormonal and Metabolic Profile in a Rat Model of Polycystic Ovary Syndrome

Abtahi-Eivari¹,

Moghimian²,

Soltani³

et al. 2017

International Journal of Women’s Health and Reproduction Scienc

View full text Add to dashboard Cite

show abstract

“…According to our results, the serum glucose level significantly decreased in treadmill exercise groups. In this context, M Rahmati et al showed that exercise on the treadmill reduced blood surge (30). The comparison of serum insulin levels in different groups showed that STZ-induced diabetes caused damage to pancreatic beta cells and reduced blood insulin levels (28,31).…”

Section: Discussionmentioning

confidence: 99%

Effect of crocin and treadmill exercise on oxidative stress and heart damage in diabetic rats

Pourmousavi¹,

Asadi²,

Zehsaz³

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective: In diabetes the production of free radicals and inflammatory agents in the heart tissue is increased and the expression of genes associated with the induction of apoptosis is altered. Considering the importance of common cardiovascular disorders in diabetes, this study investigated the effect of eight weeks of aerobic exercise and kerosene use alone, as well as tissue damage and oxidative stress caused by diabetes in the heart of adult rats. Materials and Methods: To induce diabetes, streptozotocin 50 mg/kg was injected as a single dose intraperitoneally. After 72 hours, blood glucose levels were monitored by a glucometer, and blood glucose above 250 mg/dl was considered diabetes. Continuous treadmill exercise was performed for eight weeks by placing the animal on the treadmill. Next, the animals were anesthetized, and samples were taken from the hearts and frozen in liquid nitrogen. Then, superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA) were measured in the cardiac tissue. Finally, the hearts of half of the animals were immediately immersed in formalin solution for histological changes. Results: According to our findings, diabetes increased lipid peroxidation, which was characterized by increased MDA levels in the control diabetes group and decreased SOD and GPx levels (P <0.05). It also changes the balance of expression of genes associated with apoptosis control, increased Bcl-2-associated X (Bax) expression, and decreased Bcl-2 expression (P <0.05). Also, we observed the induction of apoptosis in cardiac tissue. Using eight weeks of continuous exercise and administration of crocin significantly reduced blood sugar levels and lipid peroxidation and increased the activity of antioxidant enzymes and Bcl-2 gene expression compared to the diabetes control group. In addition, continuous exercise and kerosene improved the oxidative stress parameters in the control group. Conclusions: The results of this study showed that diabetes could cause oxidative stress and heart dysfunction. Moreover, simultaneously and separately, aerobic exercise with treadmill and crocin administration can reduce these disorders and prevent apoptosis in the heart tissue.

show abstract

“…According to our results, the serum glucose level significantly decreased in treadmill exercise groups. In this context, G. Reuter et al showed that exercise on the treadmill reduced blood surge [34]. The comparison of serum insulin levels in different groups showed that STZ-induced diabetes caused damage to pancreatic beta cells and reduced blood insulin levels [32,35].…”

Section: Plos Onementioning

confidence: 99%

Effect of crocin and treadmill exercise on oxidative stress and heart damage in diabetic rats

Pourmousavi,

Hashemkandi Asadi,

Zehsaz

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Diabetes increases the production of free radicals and inflammatory agents in the heart tissue and alters the expression of genes associated with the induction of apoptosis. Considering the importance of common cardiovascular disorders in diabetes, this study investigated the effect of eight weeks of aerobic exercise and crocin use, as well as tissue damage and oxidative stress caused by diabetes in the hearts of adult rats. Streptozotocin 50 mg/kg was injected as a single dose intraperitoneally to cause the diabetes. After 72 hours, a glucometer monitored blood glucose levels, and blood glucose above 250 mg/dl was considered diabetes. Continuous treadmill exercise was performed for eight weeks by placing the animal on the treadmill. Next, the animals were anesthetized, and samples were taken from the hearts and frozen in liquid nitrogen. Then, superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA) were measured in the cardiac tissue. Finally, the hearts of half of the animals were immediately immersed in a formalin solution for histological changes. According to our findings, diabetes increased lipid peroxidation, characterized by increased MDA levels in the control diabetes group and decreased SOD and GPx levels (P <0.05). It also changes the balance of expression of genes associated with apoptosis control, increased Bcl-2-associated X (Bax) expression, and decreased Bcl-2 expression (P <0.05). Also, we observed the induction of apoptosis in cardiac tissue. Using eight weeks of continuous exercise and administration of crocin significantly reduced blood sugar levels and lipid peroxidation and increased the activity of antioxidant enzymes and Bcl-2 gene expression compared to the diabetes control group. In addition, continuous exercise and crocin improved the oxidative stress parameters in the control group. This study showed that diabetes could cause oxidative stress and heart dysfunction. Moreover, simultaneously and separately, aerobic exercise with a treadmill and crocin administration can reduce these disorders and prevent apoptosis in the heart tissue.

show abstract

Arginin als Vorstufe von Galegin in Galega officinalis L. Zur Biochemie und Physiologie von Galegin in Galega officinalis L., III. Mitt.

Cited by 18 publications

References 7 publications

The Effect of Galega officinalis on Hormonal and Metabolic Profile in a Rat Model of Polycystic Ovary Syndrome

The Effect of Galega officinalis on Hormonal and Metabolic Profile in a Rat Model of Polycystic Ovary Syndrome

Effect of crocin and treadmill exercise on oxidative stress and heart damage in diabetic rats

Effect of crocin and treadmill exercise on oxidative stress and heart damage in diabetic rats

Contact Info

Product

Resources

About