Arginine-vasopressin attenuates beneficial norepinephrine effect on jejunal mucosal tissue oxygenation during endotoxinaemia

Maier, Stephan; Hasibeder, Walter; Pajk, Werner; Hengl, C.; Ulmer, Hanno; Hausdorfer, Hans; Wurzinger, Bettina; Knotzer, Hans

doi:10.1093/bja/aep239

Cited by 17 publications

(11 citation statements)

References 39 publications

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“…One electrode may consist of several platinum wires, each of which has a diameter of 15 μm, representing an individual measuring point and one Ag–AgCl reference electrode. These electrodes are reported to measure oxygen tension of the superficial epithelial layers [53]. Thus, although surface PO 2 electrodes have a restricted measurement depth this technique allows determination of tissue PO 2 without tissue damage and interference with the microcirculation [54].…”

Section: Monitoring Of Tissue Oxygenationmentioning

confidence: 99%

From system to organ to cell: oxygenation and perfusion measurement in anesthesia and critical care

Schober

Schwarte

2012

J Clin Monit Comput

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Maintenance or restoration of adequate tissue oxygenation is a main goal of anesthesiologic and intensive care patient management. Pathophysiological disturbances which interfere with aerobic metabolism may occur at any stage in the oxygen cascade from atmospheric gas to the mitochondria, and there is no single monitoring modality that allows comprehensive determination of “the oxygenation”. To facilitate early detection of tissue hypoxia (or hyperoxia) and to allow a goal directed therapy targeted at the underlying problem, the anesthesiologist and intensive care physician require a thorough understanding of the numerous determinants that influence cellular oxygenation. This article reviews the basic physiology of oxygen uptake and delivery to tissues as well as the options to monitor determinants of oxygenation at different stages from the alveolus to the cell.

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Section: Monitoring Of Tissue Oxygenationmentioning

confidence: 99%

From system to organ to cell: oxygenation and perfusion measurement in anesthesia and critical care

Schober

Schwarte

2012

J Clin Monit Comput

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“…A near-perfect example of how to conduct and report ANOVA is seen in the recent study of Maier et al examining the effect over time on various markers of intestinal mucosal oxygenation in pigs grouped to receive noradrenaline, arginine vasopressin, or control [16]. Using Maier's mesenteric artery blood flow result as an example, there were significant effects of 'time' and 'drug' (p < 0.001) and also the 'drug-time' interaction (p < 0.01).…”

Section: Reporting Anova Methods and Resultsmentioning

confidence: 99%

The analysis of variance in anaesthetic research: statistics, biography and history

Pandit

2010

Anaesthesia

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SummaryMultiple t-tests (or their non-parametric equivalents) are often used erroneously to compare the means of three or more groups in anaesthetic research. Methods for correcting the p value regarded as significant can be applied to take account of multiple testing, but these are somewhat arbitrary and do not avoid several unwieldy calculations. The appropriate method for most such comparisons is the 'analysis of variance' that not only economises on the number of statistical procedures, but also indicates if underlying factors or sub-groups have contributed to any significant results. This article outlines the history, rationale and method of this analysis.

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“…In one study, norepinephrine and phenylephrine improved jejunal mucosal tP O2 , but the effect was blunted by simultaneous administration of vasopressin. 68 However, in another study vasopressin alone did not compromise either mucosal tP O2 or oxygen supply in the acute phase of endotoxaemia. 69 These studies highlight the variable and still poorly understood effects of vasoactive drugs on regional blood flow and tissue oxygenation and the ongoing debate about their utility in high-risk surgical patients.…”

Section: Gut and Liver Ischaemiamentioning

confidence: 90%

Tissue oxygen tension monitoring of organ perfusion: rationale, methodologies, and literature review

Santis

Singer

2015

British Journal of Anaesthesia

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Tissue oxygen tension is the partial pressure of oxygen within the interstitial space of an organ bed. As it represents the balance between local oxygen delivery and consumption at any given time, it offers a ready monitoring capability to assess the adequacy of tissue perfusion relative to local demands. This review covers the various methodologies used to measure tissue oxygen tension, describes the underlying physiological and pathophysiological principles, and summarizes human and laboratory data published to date.

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Arginine-vasopressin attenuates beneficial norepinephrine effect on jejunal mucosal tissue oxygenation during endotoxinaemia

Abstract: Both NE and NE+AVP improved global haemodynamics and systemic oxygen transport variables when compared with control animals in an acute endotoxic pig model. NE improved jejunal PO2muc at all dosages. NE effects were significantly blunted by simultaneous administration of AVP.

Cited by 17 publications

References 39 publications

From system to organ to cell: oxygenation and perfusion measurement in anesthesia and critical care

From system to organ to cell: oxygenation and perfusion measurement in anesthesia and critical care

The analysis of variance in anaesthetic research: statistics, biography and history

Tissue oxygen tension monitoring of organ perfusion: rationale, methodologies, and literature review

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