Aripiprazol y priapismo

Aguilar-Shea, Antonio L.; Palomero-Juan, Isabel; Santos, Lucía Sierra; Gallardo-Mayo, Cristina

doi:10.1016/j.aprim.2008.09.030

Cited by 6 publications

(5 citation statements)

References 2 publications

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“…Besides, despite this characteristic, cases of priapism induced by aripiprazole have been reported ( Table 2 ). Two previous reports suggested an association between the dose of aripiprazole and priapism [ 12 , 13 ]. In 2006, Mago et al discussed a case of recurrent priapism that was associated with the administration of aripiprazole [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

A very rare case of priapism under aripiprazole in a patient followed for bipolar disorder: A CARE-compliant report

Jabiry¹,

Mansour²,

Barrimi³

et al. 2021

Annals of Medicine and Surgery

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Introduction and importance Priapism is a urological emergency characterized by abnormally prolonged, painful and irreducible erection. It occurs without a sexual stimulation and habitually exceeds 6 h. About a half of iatrogenic priapisms are believed to be associated with antipsychotics. Until to date, very few cases of aripiprazole-associated priapism were reported. Case presentation In this case report, we present the clinical findings of a 40-year-old patient that developed priapism after treatment with aripiprazole after his hospitalization for an episode of clinical mania following treatment discontinuation for bipolar I disorder. The management was successful and priapism was resolved spontaneously. Clinical discussion Despite its low affinity to alpha-1 adrenergic receptors, aripiprazole may be associated with priapism. Several potential factors involved in the pathogenesis of this adverse event have been reported in the literature including history of priapism in a different class of neuroleptics and consumption of psychoactive drugs which are the principal factors found in our case. Conclusion Priapism may occur even during treatment with antipsychotics that have a low affinity to alpha1-adrenergic receptors. All patients on antipsychotics should be informed about the risk of this rare but serious adverse event.

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Section: Discussionmentioning

confidence: 99%

A very rare case of priapism under aripiprazole in a patient followed for bipolar disorder: A CARE-compliant report

Jabiry¹,

Mansour²,

Barrimi³

et al. 2021

Annals of Medicine and Surgery

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show abstract

“…Two reports suggest an association between the dose of aripiprazole and priapism. [78] A report by Mago et al ., 2006, discusses a case of recurrent priapism with aripiprazole administration. [9] Priapism has also been reported when aripiprazole was used in combination with oxcarbazepine and lithium.…”

Section: Discussionmentioning

confidence: 99%

“…[78] But, the reason why only certain individuals develop priapism requires further elucidation. It could be an idiosyncratic reaction or related to the altered sensitivity of adrenergic receptors in this patient.…”

Section: Discussionmentioning

confidence: 99%

Aripiprazole-induced priapism

2016

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Priapism is a urologic emergency representing a true disorder of penile erection that persists beyond or is unrelated to sexual interest or stimulation. A variety of psychotropic drugs are known to produce priapism, albeit rarely, through their antagonistic action on alpha-1 adrenergic receptors. We report such a case of priapism induced by a single oral dose of 10 mg aripiprazole, a drug with the least affinity to adrenergic receptors among all atypical antipsychotics. Polymorphism of alpha-2A adrenergic receptor gene in schizophrenia patients is known to be associated with sialorrhea while on clozapine treatment. Probably, similar polymorphism of alpha-1 adrenergic receptor gene could contribute to its altered sensitivity and resultant priapism. In future, pharmacogenomics-based approach may help in personalizing the treatment and effectively prevent the emergence of such side effects.

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“…La clozapina es el antipsicótico atípico con mayor reporte de casos de priapismo desde 1992 (5), seguido por la risperidona -tanto el uso oral como el inyectable (12)-; hay reporte de priapismo en un menor de 12 años con uso de risperidona (13). La olanzapina también evidencia este efecto secundario (14)(15)(16)(17)(18)(19)(20); hay reportes con el uso de quetiapina (21,22), ziprasidona (23) y aripiprazol (24,25).…”

Section: Revisiónunclassified

“…Una vez detectado el priapismo, el clínico se enfrenta a una decisión respecto a la suspensión, disminución de la dosis, continuación o cambio de antipsicótico. En el primer reporte de priapismo con clozapina se disminuyó la dosis a la mitad, sin mejoría de la recurrencia (5); otra experiencia fue el reinicio del antipsicótico, sin presencia de nuevos episodios de priapismo (24,26); y en otros, a pesar de cambiar de antipsicóticos atípicos, se presentaba la recurrencia del efecto adverso (27,28).…”

Section: Revisiónunclassified

Priapismo asociado con el uso de clozapina. Reporte de caso

Espriella

2011

Revista Colombiana de Psiquiatría

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Aripiprazol y priapismo

Cited by 6 publications

References 2 publications

A very rare case of priapism under aripiprazole in a patient followed for bipolar disorder: A CARE-compliant report

A very rare case of priapism under aripiprazole in a patient followed for bipolar disorder: A CARE-compliant report

Aripiprazole-induced priapism

Priapismo asociado con el uso de clozapina. Reporte de caso

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