Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells

Huang, Ying-Tzu; Wu, Tzu‐Chin; Lu, Chuan-Chen; Yu, Feng‐Yih; Liu, Biing-Hui

doi:10.1016/j.toxlet.2018.03.032

Cited by 14 publications

(10 citation statements)

References 40 publications

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“…pullicaecorum -supplemented mice. The expression level of the bladder cancer-associated protein (BLCAP), which is an apoptosis-related tumor suppressor identified from bladder cancer [ 31 , 32 ], was significantly higher (29.2-fold; p < 0.05) in NaB-treated HT1376 cells than that in cells without NaB treatment ( Figure 3 A). Moreover, the immunoreactivity of BLCAP was observed in the layer of transitional epithelium of mouse urinary bladder regardless of whether mice had been treated with B .…”

Section: Resultsmentioning

confidence: 99%

“…At the same time, we observed increased BLCAP in urothelial bladder cells, not only in the HT1376 cells but also in the 5637 cells ( Supplementary Materials Figure S4 ). BLCAP exhibits a tumor suppressor function in various tumors, including urothelial cancer of the bladder [ 31 ] and can reduce cell growth by stimulating apoptosis [ 32 ]. The increase in BLCAP by B .…”

Section: Discussionmentioning

confidence: 99%

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Supplementation of Probiotic Butyricicoccus pullicaecorum Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular Signatures

Wang

Liu

et al. 2021

Diagnostics

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In bladder cancer, urothelial carcinoma is the most common histologic subtype, accounting for more than 90% of cases. Pathogenic effects due to the dysbiosis of gut microbiota are localized not only in the colon, but also in regulating bladder cancer distally. Butyrate, a short-chain fatty acid produced by gut microbial metabolism, is mainly studied in colon diseases. Therefore, the resolution of the anti-cancer effects of butyrate-producing microbes on bladder urothelial cells and knowledge of the butyrate-responsive molecules must have clinical significance. Here, we demonstrate a correlation between urothelial cancer of the bladder and Butyricicoccus pullicaecorum. This butyrate-producing microbe or their metabolite, butyrate, mediated anti-cancer effects on bladder urothelial cells by regulating cell cycle, cell growth, apoptosis, and gene expression. For example, a tumor suppressor against urothelial cancer of the bladder, bladder cancer-associated protein, was induced in butyrate-treated HT1376 cells, a human urinary bladder cancer cell line. In conclusion, urothelial cancer of the bladder is a significant health problem. To improve the health of bladder urothelial cells, supplementation of B. pullicaecorum may be necessary and can further regulate butyrate-responsive molecular signatures.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Supplementation of Probiotic Butyricicoccus pullicaecorum Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular Signatures

Wang

Liu

et al. 2021

Diagnostics

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“…Cystoscopy is accepted as the gold standard for detection and surveillance of bladder cancer; however, it is an invasive procedure that causes discomfort in patients, so some novel ancillary noninvasive biomarkers for detection of bladder cancer have been appearing [17]. Several tumor suppressor genes have been shown to be mutated in bladder cancer, such as P21, TP53, XPO5, BLCAP, and TRAP1 [18–21], and other tumor-associated genes have been demonstrated to contribute to the pathogenesis of bladder cancer, such as SPAG5 and MORC2 [22, 23]. Despite these knowledges above, the role of the kinesins in bladder cancer remains unclear, and no report has been found.…”

Section: Discussionmentioning

confidence: 99%

KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo

Tian

Jiang

et al. 2019

Disease Markers

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Background. Bladder cancer is a common malignancy with uncontrolled and rapid growth. Although lots of the important regulatory networks in bladder cancer have been found, the cancer-relevant genes remain to be further identified. Methods. We examined the KIF5A expression levels in bladder cancer and normal bladder tissue samples via immunohistochemistry and observed the effect of KIF5A on bladder tumor cell proliferation in vitro and in vivo. Additionally, a coexpression between KIF5A and KIF20B in tumor tissues was explored. Results. KIF5A expression level was higher in the bladder cancer tissues than in the adjacent nontumor tissues. Patients with higher KIF5A expression displayed advanced clinical features and shorter survival time than those with lower KIF5A expression. Moreover, KIF5A knockdown inhibited bladder cancer cell proliferation, migration, and invasion demonstrated in vivo and in vitro. In addition, coexpression was found between KIF5A and KIF20B in tumor tissues. Conclusion. The results demonstrated that KIF5A is a critical regulator in bladder cancer development and progression, as well as a potential target in the treatment of bladder cancer.

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“…On October 27, 2017, international agency for research on cancer listed AAs as a class Ⅰ carcinogen. Aristolochic acids include Aristolochic acid Ⅰ (AA Ⅰ) and Aristolochic acid Ⅱ (AA Ⅱ), and although their structures are very similar (Figure 1), AA Ⅰ exhibits the stronger cytotoxicity and carcinogenicity (Huang, Wu, Lu, Yu, & Liu, 2018;Lin et al, 2018). Therefore, in this study, we decided to concentrate on a detection method for AA Ⅰ.…”

Section: Introductionmentioning

confidence: 99%

Development of ic-ELISA and an immunochromatographic strip assay for the detection of aristolochic acid Ⅰ

Song

et al. 2019

Food and Agricultural Immunology

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Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells

Cited by 14 publications

References 40 publications

Supplementation of Probiotic Butyricicoccus pullicaecorum Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular Signatures

Supplementation of Probiotic Butyricicoccus pullicaecorum Mediates Anticancer Effect on Bladder Urothelial Cells by Regulating Butyrate-Responsive Molecular Signatures

KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo

Development of ic-ELISA and an immunochromatographic strip assay for the detection of aristolochic acid Ⅰ

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