Aronia juice suppresses the elevation of postprandial blood glucose levels in adult healthy Japanese

Yamane, Toshimi; Kozuka, Miyuki; Wada-Yoneta, Mio; Sakamoto, Tatsuji; Nakagaki, Takenori; Nakano, Yoshihisa; Ohkubo, Iwao

doi:10.1016/j.yclnex.2017.01.002

Cited by 44 publications

(22 citation statements)

References 12 publications

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“…Epidemiological studies indicate that anthocyanin consumption from different plant foods is associated with a reduced type 2 diabetes risk (Wedick et al, 2012). Chokeberry juice is a rich source of polyphenol compounds that could be effective preventive and therapeutic agents in DM type 2 (Banjari et al, 2017;Simeonov et al, 2002;Yamane et al, 2017). Chokeberry juice supplementation in patients with DM type 2 could have an impact on the patient's health and well-being.…”

Section: Discussionmentioning

confidence: 99%

Chokeberry juice supplementation in type 2 diabetic patients - impact on health status

Milutinović¹,

Radovanović²,

Šavikin³

et al. 2019

J Appl Biomed

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Recent literature evidence indicates the potential use of chokeberry preparations in the prevention and treatment of some chronic noncommunicable diseases. The aim of the present study was to evaluate the effects of the three months oral chokeberry juice supplementation in type 2 diabetic patients, as well as its influence on hematological parameters and certain parameters of the renal dysfunction. The study was designed as an open-label trial, which included 35 patients who have received the herbal supplement, polyphenol-rich chokeberry juice (150 ml/day, three times a day for 50 ml), in addition to their standard therapy. Chokeberry juice as a rich source of polyphenol compounds could be an effective preventive and therapeutic agent in diabetes mellitus type 2. Hematological and biochemical parameters were measured at baseline, after 3 months with the chokeberry juice supplementation and after the next 3 months without the chokeberry juice supplementation (follow-up period). Significant difference was noticed in the levels of LDL-cholesterol, glycated hemoglobin and serum creatinine (p < 0.05), as well as in the levels of some hematological parameters, such as white blood cell and lymphocyte count (p < 0.01), hematocrit, blood hemoglobin, mean corpuscular volume, hemoglobin and hemoglobin concentration and red blood cell count (p < 0.05). The daily consumption of the chokeberry juice could improve the health status in patients with type 2 diabetes mellitus, in combination with their standard therapy.

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Section: Discussionmentioning

confidence: 99%

Chokeberry juice supplementation in type 2 diabetic patients - impact on health status

Milutinović¹,

Radovanović²,

Šavikin³

et al. 2019

J Appl Biomed

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“…Aronia products (extracts, juices, supplements, etc.) are known from their beneficial impact on human health (Boncheva et al, ; Borowska & Brzóska, ; Yamane et al, ). Consumption of these products is recommended as a prophylactic for various diseases, including non‐communicable diseases such as diabetes, obesity, digestive system disorders, cardiovascular system disorders and cancer (Boncheva et al, ; Borowska & Brzóska, ; Jurikova et al, ; Yamane et al, ).…”

Section: Polyphenol‐rich Products In Protection and Treatment Of Cd‐imentioning

confidence: 99%

“…are known from their beneficial impact on human health (Boncheva et al, ; Borowska & Brzóska, ; Yamane et al, ). Consumption of these products is recommended as a prophylactic for various diseases, including non‐communicable diseases such as diabetes, obesity, digestive system disorders, cardiovascular system disorders and cancer (Boncheva et al, ; Borowska & Brzóska, ; Jurikova et al, ; Yamane et al, ). The study by Boncheva et al () has revealed that consumption of juice from chokeberries (200 mL daily for 60 days) improved liver function (estimated based on the serum activities of liver marker enzymes), carbohydrate metabolism and lipid parameters in the serum of people with NAFLD.…”

Section: Polyphenol‐rich Products In Protection and Treatment Of Cd‐imentioning

confidence: 99%

“…Aronia products (extracts, juices, supplements, etc.) are known from their beneficial impact on human health (Boncheva et al, 2013;Yamane et al, 2017 Boncheva et al (2013) has revealed that consumption of juice from chokeberries (200 mL daily for 60 days) improved liver function (estimated based on the serum activities of liver marker enzymes), carbohydrate metabolism and lipid parameters in the serum of people with NAFLD. Moreover, experimental investigations Kowalczyk et al, 2003), including mainly studies conducted by our research team (Borowska et al, 2017;Brzóska, Rogalska, et al, 2015;Brzóska, Rogalska, et al, 2016;Brzóska et al, 2017;Mężyńska et al, 2016, unpublished data), indicate that Aronia products may offer protection against various unfavorable effects of exposure to Cd, such as its accumulation in the body and development of oxidative stress, as well as damage to the skeleton and liver, and disorders in the metabolism of Zn and Cu.…”

Section: Chokeberrymentioning

confidence: 99%

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Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

Mężyńska

Brzóska

2018

J of Applied Toxicology

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Recently, the growing attention of the scientific community has been focused on the threat to health created by environmental pollutants, including toxic metals such as cadmium (Cd), and on the need of finding effective ways to prevent and treat the unfavorable health effects of exposure to them. Particularly promising for Cd, and thus arousing the greatest interest, is the possibility of using various ingredients present in plants, including mainly polyphenolic compounds. As the liver is one of the target organs for this toxic metal and disturbances in the proper functioning of this organ have serious consequences for health, the aim of the present review was to discuss the possibility of using polyphenol-rich food products (e.g., chokeberry, black and green tea, blueberry, olive oil, rosemary and ginger) as the strategy in protection from this xenobiotic hepatotoxicity and treatment of this heavy metal-induced liver damage. Owing to the ability of polyphenols to bind ions of Cd and the strong antioxidative potential of these compounds, as well as their abundance in dietary products, it seems to be of high importance to consider the possibility of using polyphenols as potential preventive and therapeutic agents against Cd hepatotoxicity, determined by its strong pro-oxidative properties. Although most of the data on the effectiveness of polyphenols comes from studies in animals, the fact that some of them are derived from experimental models that reflect human exposure to this metal allows us to assume that some polyphenol-rich food products may be promising protective agents against Cd hepatotoxicity in humans.

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“…High anthocyanin contents in A. melanocarpa have led to investigating the bioactives present in its extracts ( 12 , 13 ). A. melanocarpa juice (200 mL) was shown to have a potent effect on postprandial glucose in healthy subjects after an oral meal tolerance test ( 14 ). This effect was imparted regardless of the gender of the subjects and was additionally shown to reduce the activity of dipeptidyl peptidase IV, α-glucosidase, and angiotensin-converting enzyme (ACE) in a dose-dependent manner ( 14 ).…”

Section: Antidiabetic Effects Of a Melanocarpamentioning

confidence: 99%

Antidiabetic Effects of Aronia melanocarpa and Its Other Therapeutic Properties

et al. 2017

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Diabetes is a global pandemic which warrants urgent attention due to its rising prevalence and economic burden. Thus, many alternative therapies are being researched for antidiabetic properties, given the inefficacy of current medicinal treatments. From this perspective, Aronia melanocarpa or black chokeberry has been investigated for its therapeutic properties in many studies, especially for its ability to combat hyperglycemia-induced oxidative stress and the macrovascular complications of diabetes including cardiovascular disease. Though A. melanocarpa is native to the eastern areas of North America, it has been planted extensively in Europe and Asia as well. Several in vivo studies have displayed the antioxidant properties of A. melanocarpa berry juice and plant extract in rat models where oxidative stress markers were observed to have significant reductions. Some of the potent bioactive compounds present in the fruits and other parts of the plant were identified as (−)-epicatechin, chlorogenic acid, neochlorogenic acid, and cyanidin-3-galactoside. Overall, A. melanocarpa could be considered a good source of antioxidants which is effective in combating hyperglycemia-induced oxidative stress.

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Aronia juice suppresses the elevation of postprandial blood glucose levels in adult healthy Japanese

Abstract: of these enzyme activities and may be useful for prevention of metabolic diseases in adult healthy Japanese.

Cited by 44 publications

References 12 publications

Chokeberry juice supplementation in type 2 diabetic patients - impact on health status

Chokeberry juice supplementation in type 2 diabetic patients - impact on health status

Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

Antidiabetic Effects of Aronia melanocarpa and Its Other Therapeutic Properties

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