Artemether for topical use in patients with seborrhoeic keratosis

Härtel, A.; Jung, T. S.; Carter, R. Sift

doi:10.1111/bjd.16930

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Six patients reported mild temporary itching, five patients' skin burning, and two patients slight erythema. 51 Trichloroacetic acid 65% peel (cohort study) According to the results of the clinician's evaluation, 57% had a great response to treatment, and 58% of patients said they were completely satisfied. Results remained consistent for over 13 months.…”

Section: Topicalmentioning

confidence: 99%

Update of pathophysiology and treatment options of seborrheic keratosis

Gorai¹,

Ahmad

Raza

et al. 2022

Dermatologic Therapy

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Seborrheic keratosis (SK) is a common, benign tumor that can occur on everybody site and can be conservatively managed. Cosmetic concerns, especially when a lesion involves the facial area, are the most common reason for excision. SK shows male gender preponderance and increasing age is an independent association with the condition. Even though more prevalent in the elderly, it has also been reported in younger age groups like adolescents and young adults. Precise pathogenesis is still obscure, but ultra-violet exposure represents a predisposing factor to SK by altering the biochemical concentration and expression of factors like Glutamine deaminases, endothelin, and stem cell factor. Moreover, the accumulation of amyloid-associated protein has also been postulated. Involvement of genitalia has been associated with human papillomavirus infection. Recently, Merkel cell polyomavirus nucleic acid was also detected in SK. Several oncogenic mutations involving FGFR-3 and FOXN1 have been identified. SKs are usually classified clinically and histologically. Dermatoscopy is a noninvasive alternative diagnostic technique widely used in differentiating SK from other benign and malignant tumors. In terms of treatment, topical agents, shave dissection, cryosurgery, electrodesiccation, laser application and curettage under local anesthesia are safe methods for eradication of SKs, mostly for cosmetic purposes. Though generally safe, the latter techniques may occasionally cause postprocedure depigmentation, scarring, and recurrence. Nanosecond-pulsed electric field technology is a promising new technique with fewer side-effects.

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Section: Topicalmentioning

confidence: 99%

Update of pathophysiology and treatment options of seborrheic keratosis

Gorai¹,

Ahmad

Raza

et al. 2022

Dermatologic Therapy

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“…Transdermal drug delivery avoids complications related to parenteral injections (contamination, technical difficulty related to repeated intravenous injections) as well as oral treatment (gastrointestinal side effects, first pass metabolism, coma and vomiting) and compliance ( Shen et al, 2015 ). Topical or transcutaneous treatment by spraying artemisinins in various formulations has been suggested for elevating allergy symptoms, anesthetic purposes, wounds healing, and skin cancer ( Härtel et al, 2018 ; Li et al, 2012 ; Nnamani et al, 2014 ; Wong et al, 2020 ). Other transdermal methods of applying artemisinins (and other drugs) were suggested to treat malaria, mostly with limited success (see Introduction).…”

Section: Discussionmentioning

confidence: 99%

Transdermal delivery of artemisinins for treatment of pre-clinical cerebral malaria

Zech

Dzikowski

Simantov

et al. 2021

International Journal for Parasitology: Drugs and Drug Resistan

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Transdermal drug delivery avoids complications related to oral or parenteral delivery - the need for sterility, contamination, gastrointestinal side effects, patient unconsciousness or nausea and compliance. For malaria treatment, we demonstrate successful novel transdermal delivery of artemisone (ART) and artesunate. The incorporation of ART into a microemulsion (ME) overcomes the limitations of the lipophilic drug and provides high transcutaneous bioavailability. ART delivery to the blood (above 500 ng/ml) was proved by examining the sera from treated mice, using a bioassay in cultured Plasmodium falciparum. Skin spraying of ART-ME eliminated P. berghei ANKA in an infected mouse model of cerebral malaria (CM) and prevented CM, even after a late treatment with a relatively small amount of ART (13.3 mg/kg). For comparison, the artesunate (the most used commercial artemisinin) formulation was prepared as ART. However, ART-ME was about three times more efficient than artesunate-ME. The solubility and stability of ART in the ME, taken together with the successful transdermal delivery leading to animal recovery, suggest this formulation as a potential candidate for transdermal treatment of malaria.

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Artemether for topical use in patients with seborrhoeic keratosis

Cited by 2 publications

References 7 publications

Update of pathophysiology and treatment options of seborrheic keratosis

Update of pathophysiology and treatment options of seborrheic keratosis

Transdermal delivery of artemisinins for treatment of pre-clinical cerebral malaria

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