2019
DOI: 10.18585/inabj.v11i1.531
|View full text |Cite
|
Sign up to set email alerts
|

Artemisia annua Leaf Extract Increases GLUT-4 Expression in Type 2 Diabetes Mellitus Rat

Abstract: BACKGROUND: The depletion of glucose transporter 4 (GLUT-4) affects blood glucose level in the type 2 diabetes mellitus (T2DM) patient. Herbals supplementation such as Artemisia annua is known to posses an antidiabetic potency, but its effect on long term glucose control marker, glicated hemoglobin (HbA1C) and muscle GLUT-4 expression still has not been investigated.METHODS: Twenty Wistar rats were divided into four groups (five rats per group). The C1 group was consist of healthy control rats and C2 group was… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
5
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(5 citation statements)
references
References 22 publications
0
5
0
Order By: Relevance
“…AA has also been used for treating diabetes and improving insulin sensitivity in herbal medicine. These biomedical activities of AA may be due to its chemical constituents, which include polyphenols, avonoids, and lignans [9,10]. Considering that these constituents are a part of compounds with low solubility in water, their absorption could be restricted when administered orally [12].…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…AA has also been used for treating diabetes and improving insulin sensitivity in herbal medicine. These biomedical activities of AA may be due to its chemical constituents, which include polyphenols, avonoids, and lignans [9,10]. Considering that these constituents are a part of compounds with low solubility in water, their absorption could be restricted when administered orally [12].…”
Section: Discussionmentioning
confidence: 99%
“…The observed changes in liver function tests in different groups are illustrated in Figure (9). HF/HS-fed rats exhibited a deteriorated liver function manifested by dramatic elevation (𝑃 < 0.001) in serum activities of AST, ALT, and ALP (1.56, 3, and 1.02 folds, respectively) compared to normal control rats.…”
Section: Oral Glucose Tolerance Testmentioning
confidence: 97%
See 1 more Smart Citation
“…The mixture of several probiotics strain may interfere the type-1 DM development trough controlling the inflammation, prevention of pancreatic β-cell death, increasing the production and expression of IL-10, that is an anti-inflammatory cytokine. (29,30)…”
Section: Discussionmentioning
confidence: 99%
“…This disease is incurable and once diagnosed requires lifelong treatment [ 119 ]. A. absinthium extracts showed an insulin-sensitizing action due to their role in adenosine monophosphate-activated protein kinase (AMPK) stimulation and glucose transporter type 4 (GLUT4) translocation to the cell surface of the muscle [ 120 ]. In diabetic rats treated with A. absinthium , the metabolic pathway shifted towards carbohydrate as a source of energy, preserving proteins and lipids while increasing their production, leading to preventing body weight loss [ 121 ].…”
Section: Pharmacological Effects Of Artemisia Spp ...mentioning
confidence: 99%