Artemisia L. Fruit Extract Normalized Diabetic and Liver Function Parameters in Streptozotocin-Induced Diabetic Mice

Abstract

Many other researchers studied the effect of many part from Artemisia but not fruit on the diabetes. Artemisia fruits were used in this study, they had been dried and grinded then some chemical analyses were done to determine the active compounds of the fruits in both hot and cold extract. Since our results shows that the hot extract has more active compounds from the cold, the hot extract of Artemisia L. fruit were used in this study to determine the efficacy of it as diabetic treatment in streptozotocin-induced diabetic mice. Streptozocin (STZ) was used to induce diabetes in 35 mice which divided to 5 groups. One group consumed normal saline while the other four consumed Artemisia with four different concentrations. Another 10 mice weren't injected with STZ which were they had been divided to two groups; one consumed Artemisia and the other consumed normal saline. The fasting blood sugar (FBS) was determined on different period; zero time, 7 and 14 days after treatment. The mice were scarified and blood was collected. Insulin, GOT and GPT levels were determine in serum. FBS was higher in all STZ-induced diabetic mice dropped to normal after 14 days. The FBS of mice, treated with 500 Artemisia/ kg mice, was closer to control. Insulin level was lower in STZ-induce diabetic mice without treatment raised to normal after treatment with 500 and 1000 mg Artemisia/ kg mice. Same results were found for GOT and GPT levels. As conclusion, Artemisia appears to be a good modulator for diabetes especially at 500 and 1000 mg Artemisia/ kg body weight.

Oxidative stress in liver of streptozotocin-induced diabetic mice fed a high-fat diet: A treatment role of Artemisia annua L.

“…Oxidative stress leads to an increase in reactive oxygen species (ROS) (Taile et al 2020) or free radicals, malondialdehyde (MDA), and glutathione (GSH) in the liver (Guven et al 2006;Mohamed et al 2016;Deayu Putri et al 2020;Eltayef et al 2020).…”