Arterial compliance changes in diabetic normotensive patients after angiotensin converting enzyme inhibition therapy

Manolis, Athanasios; Iraklianou, Stella; Pittaras, Andreas; Zairis, Michael N.; Psaltiras, G.; Loukatzikou, E.; Koutsi, E.; Foussas, Stefanos

doi:10.1016/s0735-1097(03)82236-2

Cited by 9 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Certain drugs have been successfully used for the management of ED and AS and therefore for the prevention of potential DM complications. [12][13][14] Early diagnosis and early management of ED and AS may reduce diabetic complications. In this study, we aimed to detect ED and AS and determine the association with diastolic dysfunction in children with DM who had no complications.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction

Çiftel

Ertuğ

Parlak

et al. 2013

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

Objective: The objective of this study is to investigate endothelial dysfunction (ED) and arterial stiffness (AS) and determine the association with diastolic dysfunction in children with type 1 diabetes mellitus (DM). Methods: A total of 42 patients without diabetic complications (mean age: 13.21 years) and 40 healthy (mean age: 13.07 years) children were included in this study. AS was assessed with ascending aorta M-mode measurements, diastolic dysfunction with pulsed wave (PW) Doppler and tissue Doppler echocardiography measurements and flow-mediated dilatation (FMD) and carotid intima-media thickness (CIMT) with high-resolution ultrasonography. Results: Results of diabetic group and healthy children were compared. In diabetic group, aortic strain (8.40 ± 2.98, 20.12 ± 5.04; p < 0.001), aortic distensibility (7.36 ± 2.92, 16.59 ± 4.25; p < 0.001) and FMD% (7.70 ± 2.83, 11.33 ± 2.85; p < 0.001) were found decreased, and CIMT (0.52 ± 0.09 mm, 0.47 ± 0.08 mm; p < 0.05) was found increased. Additionally, left ventricular lateral segment and right ventricular free-wall isovolumic relaxation time (IVRT) and myocardial performance index (MPI) were found increased. Correlation analyses demonstrated a negative correlation between FMD and IVRT and MPI. Conclusions: ED and AS were found in type 1 DM patients without diabetic complications. Additionally, correlation was shown between increased AS and ED and right and left ventricular diastolic dysfunctions.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Additionally, management of ED and AS with certain experimental drugs and/or some medication used in clinical practice is promising regarding prevention of diabetic complications. [12][13][14] Furthermore, management of ED and AS is likely to decrease the incidence of cardiovascular disease, which is an important cause of mortality in DM.…”

Section: Discussionmentioning

confidence: 99%

Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction

Çiftel

Ertuğ

Parlak

et al. 2013

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

show abstract

“…Indeed, ACE inhibition was shown to reverse arterial stiffness in diabetic normotensive patients. 51 Unlike the B 2 Rs, which are constitutively expressed throughout and mediate the majority of the vascular and metabolic actions of kinins, as mentioned above, the B 1 Rs are generally absent from normal tissues, but are known to become induced by a variety of pathological conditions, including inflammation, the presence of toxins, cytokines or tissue trauma. 21,52 They were also found to become induced and upregulated by disturbances in circulatory homeostasis, such as induction of experimental hypertension by salt loading, renal artery clipping or exogenous Angiotensin II (Ang II) infusion 41,53 as well as by the normal aging process.…”

Section: Bradykinin Receptorsmentioning

confidence: 99%

Cardioprotective properties of bradykinin: role of the B2 receptor

et al. 2010

View full text Add to dashboard Cite

Following the introduction of angiotensin-converting enzyme (ACE) inhibitors in the treatment of hypertension and ischemic heart disease, there has been increasing interest in the bradykinin-mediated aspects of ACE inhibition. Several preclinical and clinical studies have been conducted using genetically engineered animals or pharmacological agonists and antagonists of the two receptors of bradykinin, B 1 R and B 2 R. The results have mostly indicated that the B 1 R, whose expression is induced by tissue damage, seem to have mostly noxious effects, whereas the constitutively expressed B 2 R, when activated, exert mostly beneficial actions. Accumulating evidence in the recent literature suggests that the B 2 R have an important role in the process of ischemic post-conditioning that limits the ischemia/reperfusion injury of the myocardium. In this article, we describe a series of experiments conducted on mice submitted to acute myocardial infarct and treated either with ACE inhibition (which produces potentiation of bradykinin resulting in non-selective B 1 R and B 2 R activation) or with a potent and highly selective B 2 R agonist. These data suggest that this latter pharmacological approach offers functional and structural benefits and is therefore a promising cardioprotective therapeutic modality against acute ischemic events. INTRODUCTIONThe possible role of bradykinin (BK) in cardiovascular regulation has intrigued scientists for many years. A member of the kinin system discovered in the late 1920s, BK is a nonapeptide whose existence was first recognized by Roha e Silva et al. 1 from its effects on intestinal smooth muscle. Since then, several other actions of BK were described, including vascular contraction and relaxation, participation in the process of inflammatory reactions, interaction with central and peripheral neural structures, stimulation of synthesis and release of various vasoactive substances, enhanced insulin-dependent glucose transport and utilization, etc.Circulatory homeostasis is the result of a constant equilibrium between vasoconstrictors (e.g., pressor neurohormonal factors like angiotensin II, catecholamines, vasopressin, endothelin) and vasodilators (like kinins, prostaglandins, NO, etc.). Bradykinin, a tissue hormone that regulates the regional blood flows of vital organs, is an important member of the latter group. 2 The role of BK in cardiovascular regulation under physiological and pathological conditions attracted the interest of clinicians with the advent of angiotensinconverting enzyme (ACE) inhibitors, which in the last two decades have become standard therapy for hypertension, ischemic heart disease and heart failure. 3 In recent years the work of many investigators has produced a lot of new information regarding the role of kinins in the pathophysiology of hypertension and the prevention of its end-organ complications.

show abstract

“…Our findings agree with those of previous studies that used perindopril in similar doses and found minimal haemodynamic effects in normotensives. 8,26 It should be emphasized that the relatively small number of patients included in this study was a limitation that prevents the drawing of certain conclusions concerning the above results. Because the selection of participants was based strictly on normal BP and normal myocardial perfusion SPECT scintigraphy, it was difficult to recruit a larger number of subjects.…”

Section: Discussionmentioning

confidence: 92%

Effect of angiotensin-converting enzyme inhibitors on systemic inflammation and myocardial sympathetic innervation in normotensive patients with type 2 diabetes mellitus

et al. 2007

View full text Add to dashboard Cite

Arterial compliance changes in diabetic normotensive patients after angiotensin converting enzyme inhibition therapy

Cited by 9 publications

References 0 publications

Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction

Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction

Cardioprotective properties of bradykinin: role of the B2 receptor

Effect of angiotensin-converting enzyme inhibitors on systemic inflammation and myocardial sympathetic innervation in normotensive patients with type 2 diabetes mellitus

Contact Info

Product

Resources

About