Arterial Oxygen Saturation and Hemoglobin Mass in Postmenopausal Untrained and Trained Altitude Residents

Cristancho, Edgar; Reyes, O.; Serrato, Mauricio; Mora‐Plazas, Mercedes; Rojas, Juan David; Robinson, Yohan; Böning, Dieter

doi:10.1089/ham.2007.8406

Cited by 12 publications

(17 citation statements)

References 46 publications

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“…This is not fully unexpected because a larger stimulating effect of progesterone rather than estrogen on respiration has been described occasionally, but was not uniformly observed (reviewed in Cristancho et al. and MacNutt et al. ).…”

Section: Discussionmentioning

confidence: 87%

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Diurnal changes of arterial oxygen saturation and erythropoietin concentration in male and female highlanders

et al. 2016

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In Caucasians and Native Americans living at altitude, hemoglobin mass is increased in spite of erythropoietin concentrations ([Epo]) not markedly differing from sea level values. We hypothesized that a nocturnal decrease of arterial oxygen saturation (SaO2) causes a temporary rise of [Epo] not detected by morning measurements. SaO2 (continuous, finger oximeter) and [Epo] (ELISA, every 4 h) were determined in young highlanders (altitude 2600 m) during 24 h of usual daily activity. In Series I (six male, nine female students), SaO2 fell during the night with the nadir occurring between 01:00 and 03:00; daily means (range 92.4–95.2%) were higher in females (+1.7%, P < 0.01). [Epo] showed opposite changes with zenith occurring at 04:00 without a sex difference. Mean daily values (22.9 ± 10.7SD U/L) were higher than values obtained at 08:00 (17.2 ± 9.5 U/L, P < 0.05). In Series II (seven females), only SaO2 was measured. During follicular and luteal phases, SaO2 variation was similar to Series I, but the rhythm was disturbed during menstruation. While daily [Epo] variations at sea level are not homogeneous, there is a diurnal variation at altitude following changes in SaO2. Larger hypoventilation‐dependent decreases of alveolar PO2 decreases during the night probably cause a stronger reduction of SaO2 in highlanders compared to lowlanders. This variation might be enlarged by a diurnal fluctuation of Hb concentration. In spite of a lower [Hb], the higher SaO2 in women compared to men led to a similar arterial oxygen content, likely explaining the absence of differences in [Epo] between sexes.

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Section: Discussionmentioning

confidence: 87%

“…; Cristancho et al. ). In contrast to Tibetans, genetic adaptation of HIF α probably does not play a role in Epo secretion among Andean natives (Bigham et al.…”

Section: Introductionmentioning

confidence: 98%

Diurnal changes of arterial oxygen saturation and erythropoietin concentration in male and female highlanders

et al. 2016

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“…La testosterona no solo tiene un efecto estimulador de la eritropoyesis sino también inhibe la ventilación (28) , mientras que el estradiol inhibe la eritropoyesis y estimula la ventilación (29,30) . En ese sentido, un incremento en los niveles de estrógenos circulantes se asocia con mayores valores de saturación arterial de oxígeno (31) .…”

Section: Hormonas Y Adaptación a La Alturaunclassified

Hemoglobina y testosterona: importancia en la aclimatación y adaptación a la altura

Gonzales

2011

Rev Peru Med Exp Salud Publica

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RESUMENLos diferentes tipos de mecanismos que emplea el organismo cuando se enfrenta a una situación de hipoxia incluyen la acomodación, la aclimatación y la adaptación. La acomodación es la respuesta inicial a la exposición aguda a la hipoxia de altura y se caracteriza por aumento de la ventilación y de la frecuencia cardiaca. La aclimatación se presenta en los individuos que están temporalmente expuestos a la altura y, que en cierto grado, les permite tolerar la altura. En esta fase hay un incremento en la eritropoyesis, se incrementa la concentración de hemoglobina y mejora la capacidad de transporte de oxígeno. La adaptación es el proceso de aclimatación natural donde entra en juego las variaciones genéticas y la aclimatación que les permiten a los individuos vivir sin dificultad en la altura. La testosterona es una hormona que regula la eritropoyesis y la ventilación, podría estar asociada con los procesos de aclimatación y adaptación a la altura. La eritrocitosis excesiva que conduce al mal de montaña crónico es causada por una baja saturación arterial de oxígeno, una ineficiencia ventilatoria y reducida respuesta ventilatoria a la hipoxia. La testosterona se incrementa en la exposición aguda en la altura y en los nativos de altura con eritrocitosis excesiva. Los resultados de las investigaciones actuales permitirían concluir que el incremento de la testosterona y de la hemoglobina son buenas para la aclimatación adquirida pues mejoran el transporte de oxígeno pero no para la adaptación a la altura, dado que valores altos de testosterona en suero se asocian con eritrocitosis excesiva.Palabras clave: Testosterona, Eritropoyesis, Altitud, Aclimatación, Adaptación Fisiológica (fuente: DeCS BIREME). HEMOGLOBIN AND TESTOSTERONE: IMPORTANCE ON HIGH ALTITUDE ACCLIMATIZATION AND ADAPTATION ABSTRACTThe different types of response mechanisms that the organism uses when exposed to hypoxia include accommodation, acclimatization and adaptation. Accommodation is the initial response to acute exposure to high altitude hypoxia and is characterized by an increase in ventilation and heart rate. Acclimatization is observed in individuals temporarily exposed to high altitude, and to some extent, it enables them to tolerate the high altitudes. In this phase, erythropoiesis is increased, resulting in higher hemoglobin and hematocrit levels to improve oxygen delivery capacity. Adaptation is the process of natural acclimatization where genetical variations and acclimatization play a role in allowing subjects to live without any difficulties at high altitudes. Testosterone is a hormone that regulates erythropoiesis and ventilation and could be associated to the processes of acclimatization and adaptation to high altitude. Excessive erythrocytosis, which leads to chronic mountain sickness, is caused by low arterial oxygen saturation, ventilatory inefficiency and reduced ventilatory response to hypoxia. Testosterone increases during acute exposure to high altitude and also in natives at high altitude with excessive erythrocytosis. R...

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“…This is different to healthy subjects who always show a decrease of PaCO 2 at high work load. The arterial oxygen saturation in patients at rest is as low as in highlanders [46], [47] living 2600 m above sea level (inspiratory PO 2 approx. 120 mmHg).…”

Section: Discussionmentioning

confidence: 91%

“…But in spite of a similar reduction of spirometric values the female patients show higher PO 2 and lower PCO 2 than the male patients like their healthy counterparts. Probably the long-known stimulation of respiratory brain centres by female hormones important for fetal oxygen supply is the cause (reviewed in [47]). The fact that arterialized pH is equal in all subgroups in spite of differences in PCO 2 demonstrates the importance of acid-base homeostasis for physiological functions.…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin Oxygen Affinity in Patients with Cystic Fibrosis

et al. 2014

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In patients with cystic fibrosis lung damages cause arterial hypoxia. As a typical compensatory reaction one might expect changes in oxygen affinity of hemoglobin. Therefore position (standard half saturation pressure P50st) and slope (Hill’s n) of the O2 dissociation curve as well as the Bohr coefficients (BC) for CO2 and lactic acid were determined in blood of 14 adult patients (8 males, 6 females) and 14 healthy controls (6 males, 8 females). While Hill’s n amounted to approximately 2.6 in all subjects, P50st was slightly increased by 1mmHg in both patient groups (controls male 26.7±0.2, controls female 27.0±0.1, patients male 27.7±0.5, patients female 28.0±0.3 mmHg; mean and standard error, overall p<0.01). Main cause was a rise of 1–2 µmol/g hemoglobin in erythrocytic 2,3-biphosphoglycerate concentration. One patient only, clearly identified as an outlier and with the mutation G551D, showed a reduction of both P50st (24.5 mmHg) and [2,3-biphosphoglycerate] (9.8 µmol/g hemoglobin). There were no differences in BCCO2, but small sex differences in the BC for lactic acid in the controls which were not detectable in the patients. Causes for the right shift of the O2 dissociation curve might be hypoxic stimulation of erythrocytic glycolysis and an increased red cell turnover both causing increased [2,3-biphosphoglycerate]. However, for situations with additional hypercapnia as observed in exercising patients a left shift seems to be a more favourable adaptation in cystic fibrosis. Additionally when in vivo PO2 values were corrected to the standard conditions they mostly lay left of the in vitro O2 dissociation curve in both patients and controls. This hints to unknown fugitive factors influencing oxygen affinity.

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Arterial Oxygen Saturation and Hemoglobin Mass in Postmenopausal Untrained and Trained Altitude Residents

Cited by 12 publications

References 46 publications

Diurnal changes of arterial oxygen saturation and erythropoietin concentration in male and female highlanders

Diurnal changes of arterial oxygen saturation and erythropoietin concentration in male and female highlanders

Hemoglobina y testosterona: importancia en la aclimatación y adaptación a la altura

Hemoglobin Oxygen Affinity in Patients with Cystic Fibrosis

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