Arterial spin labeling clinical applications for brain tumors and tumor treatment complications: A comprehensive case-based review

Luna, Licia P.; Ahmed, Amara; Besheli, Laleh Daftari; Deng, Francis; Intrapiromkul, Jarunee; Lanzman, Bryan; Yedavalli, Vivek

doi:10.1177/19714009221114444

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…ASL (arterial spin labeling) is a technique that enables estimation of cerebral blood flow (CBF) by imaging the magnetically labeled inflowing blood ( 111 ), and it has been increasingly employed in brain tumor imaging studies as a perfusion technique ( 112 – 114 ). Similarly to DSC-derived CBV, ASL-derived CBF has also been shown to correlate with microvascular density ( 115 ).…”

Section: Integration Of Additional Sequencesmentioning

confidence: 99%

Standardized brain tumor imaging protocols for clinical trials: current recommendations and tips for integration

Sanvito,

Kaufmann,

Cloughesy

et al. 2023

Front. Radiol.

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Standardized MRI acquisition protocols are crucial for reducing the measurement and interpretation variability associated with response assessment in brain tumor clinical trials. The main challenge is that standardized protocols should ensure high image quality while maximizing the number of institutions meeting the acquisition requirements. In recent years, extensive effort has been made by consensus groups to propose different “ideal” and “minimum requirements” brain tumor imaging protocols (BTIPs) for gliomas, brain metastases (BM), and primary central nervous system lymphomas (PCSNL). In clinical practice, BTIPs for clinical trials can be easily integrated with additional MRI sequences that may be desired for clinical patient management at individual sites. In this review, we summarize the general concepts behind the choice and timing of sequences included in the current recommended BTIPs, we provide a comparative overview, and discuss tips and caveats to integrate additional clinical or research sequences while preserving the recommended BTIPs. Finally, we also reflect on potential future directions for brain tumor imaging in clinical trials.

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Section: Integration Of Additional Sequencesmentioning

confidence: 99%

Standardized brain tumor imaging protocols for clinical trials: current recommendations and tips for integration

Sanvito,

Kaufmann,

Cloughesy

et al. 2023

Front. Radiol.

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Differentiation Between High‐Grade Glioma and Brain Metastasis Using Cerebral Perfusion‐Related Parameters (Cerebral Blood Volume and Cerebral Blood Flow): A Systematic Review and Meta‐Analysis of Perfusion‐weighted MRI Techniques

Mohammadi,

Ghaderi,

Jouzdani

et al. 2024

Magnetic Resonance Imaging

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BackgroundDistinguishing high‐grade gliomas (HGGs) from brain metastases (BMs) using perfusion‐weighted imaging (PWI) remains challenging. PWI offers quantitative measurements of cerebral blood flow (CBF) and cerebral blood volume (CBV), but optimal PWI parameters for differentiation are unclear.PurposeTo compare CBF and CBV derived from PWIs in HGGs and BMs, and to identify the most effective PWI parameters and techniques for differentiation.Study TypeSystematic review and meta‐analysis.PopulationTwenty‐four studies compared CBF and CBV between HGGs (n = 704) and BMs (n = 488).Field Strength/SequenceArterial spin labeling (ASL), dynamic susceptibility contrast (DSC), dynamic contrast‐enhanced (DCE), and dynamic susceptibility contrast‐enhanced (DSCE) sequences at 1.5 T and 3.0 T.AssessmentFollowing the PRISMA guidelines, four major databases were searched from 2000 to 2024 for studies evaluating CBF or CBV using PWI in HGGs and BMs.Statistical TestsStandardized mean difference (SMD) with 95% CIs was used. Risk of bias (ROB) and publication bias were assessed, and I2 statistic was used to assess statistical heterogeneity. A P‐value<0.05 was considered significant.ResultsHGGs showed a significant modest increase in CBF (SMD = 0.37, 95% CI: 0.05–0.69) and CBV (SMD = 0.26, 95% CI: 0.01–0.51) compared with BMs. Subgroup analysis based on region, sequence, ROB, and field strength for CBF (HGGs: 375 and BMs: 222) and CBV (HGGs: 493 and BMs: 378) values were conducted. ASL showed a considerable moderate increase (50% overlapping CI) in CBF for HGGs compared with BMs. However, no significant difference was found between ASL and DSC (P = 0.08).Data ConclusionASL‐derived CBF may be more useful than DSC‐derived CBF in differentiating HGGs from BMs. This suggests that ASL may be used as an alternative to DSC when contrast medium is contraindicated or when intravenous injection is not feasible.Level of Evidence1.Technical EfficacyStage 2.

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Imaging Cancer in Neuroradiology

Raslan

Öztürk

Oğuz

et al. 2023

Current Problems in Cancer

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Arterial spin labeling clinical applications for brain tumors and tumor treatment complications: A comprehensive case-based review

Cited by 4 publications

References 40 publications

Standardized brain tumor imaging protocols for clinical trials: current recommendations and tips for integration

Standardized brain tumor imaging protocols for clinical trials: current recommendations and tips for integration

Differentiation Between High‐Grade Glioma and Brain Metastasis Using Cerebral Perfusion‐Related Parameters (Cerebral Blood Volume and Cerebral Blood Flow): A Systematic Review and Meta‐Analysis of Perfusion‐weighted MRI Techniques

Imaging Cancer in Neuroradiology

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