Arterial spin labelling MRI for detecting pseudocapsule defects and predicting renal capsule invasion in renal cell carcinoma

Zhang, H; Wu, Yinghua; Wang, Handong; Zuo, Panli; Oesingmann, Niels; Gan, Qi; Huang, Zixing; Wu, Mingxiang; Hu, Fubi; Kuang, Min; Song, Bin

doi:10.1016/j.crad.2017.06.003

Cited by 7 publications

(6 citation statements)

References 28 publications

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“…Synchronized breathing (e.g., [ 16 , 33 ]) arguably requires even higher levels of patient compliance. Respiratory-triggering using bellows allows scans to be performed under free-breathing [ 15 , 79 ], but lengthens the scan time and does not compensate for respiratory movement completely. Standard respiratory triggering implementations may require modifications (e.g., [ 55 ]) to cope with the time gap between trigger and data acquisition, particularly in multi-PLD protocols.…”

Section: Challengesmentioning

confidence: 99%

“…Signal averaging (used in the majority of renal ASL studies acquiring up to 100 control/label pairs [ 61 ], even though acquisitions with a range of 20–30 pairs are more common) suppresses artifacts, boosts perfusion-weighted SNR, and enables data rejection approaches (e.g., [ 27 ]) in the post-processing stage at the expense of additional scan time. Rejection of corrupted data can be performed by visual inspection of the data (e.g., [ 79 ]), or using automatic approaches, such as [ 58 , 80 , 81 , 82 ]. Image registration is particularly advantageous as it preserves SNR.…”

Section: Challengesmentioning

confidence: 99%

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Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities

2018

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Tissue perfusion allows for delivery of oxygen and nutrients to tissues, and in the kidneys is also a key determinant of glomerular filtration. Quantification of regional renal perfusion provides a potential window into renal (patho) physiology. However, non-invasive, practical, and robust methods to measure renal perfusion remain elusive, particularly in the clinic. Arterial spin labeling (ASL), a magnetic resonance imaging (MRI) technique, is arguably the only available method with potential to meet all these needs. Recent developments suggest its viability for clinical application. This review addresses several of these developments and discusses remaining challenges with the emphasis on renal imaging in human subjects.

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Section: Challengesmentioning

confidence: 99%

Section: Challengesmentioning

confidence: 99%

Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities

2018

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“…According to emerging research, innovative and more recent sequences, such as Arterial Spin Labelling, in combination with classical T2 sequences, could further improve the detection of PC invasion [20].…”

Section: Discussionmentioning

confidence: 99%

Accuracy of magnetic resonance imaging to identify pseudocapsule invasion in renal tumors

et al. 2019

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Purpose To evaluate accuracy of MRI in detecting renal tumor pseudocapsule (PC) invasion and to propose a classification based on imaging of PC status in patients with renal cell carcinoma. Methods From January 2017 to June 2018, 58 consecutive patients with localized renal cell carcinoma were prospectively enrolled. MRI was performed preoperatively and PC was classified, according to its features, as follows: MRI-Cap 0 (absence of PC), MRI-Cap 1 (presence of a clearly identifiable PC), MRI-Cap 2 (focally interrupted PC), and MRI-Cap 3 (clearly interrupted and infiltrated PC). A 3D image reconstruction showing MRI-Cap score was provided to both surgeon and pathologist to obtain complete preoperative evaluation and to compare imaging and pathology reports. All patients underwent laparoscopic partial nephrectomy. In surgical specimens, PC was classified according to the renal tumor capsule invasion scoring system (i-Cap). Results A concordance between MRI-Cap and i-Cap was found in 50/58 (86%) cases. ρ coefficient for each MRI-cap and iCap categories was: MRI

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“…A recent magnetic resonance imaging (MRI) study showed that arterial spin labeling can be used to predict renal capsule invasion. [ 22 ] Other studies showed that the characterization of the renal capsule using MRI could reach 95% accuracy. [ 23 – 25 ] The present study suggests signs that could predict renal capsule invasion prior to initiating any treatment.…”

Section: Discussionmentioning

confidence: 99%

Multislice spiral computed tomography signs of invasion of the renal capsule by renal cell carcinoma

Zhang¹,

Tian²,

Zhang³

et al. 2018

Medicine

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Capsular invasion is frequently detected in localized renal cell carcinoma (RCC) specimens and is associated with a poor prognosis, but the pretreatment imaging features are poorly known. This study aimed to explore the positions and margin types of RCC and various computed tomography (CT) signs, as well as the correlations with the presence/absence of RCC invasion of the renal capsule.This was a retrospective study of 158 consecutive patients treated for pathologically confirmed RCC between January 2013 and December 2016 at the Nantong University Affiliated Hospital. The patients were divided into the capsule invasion and noninvasion groups. The CT signs were analyzed (position type, margin type, and CT findings in the perirenal fat).There were 92 (58.2%) men and 66 (41.8%) women; mean age was 59.1 ± 12.8. Renal capsule invasion was confirmed in 45 cases. There was no difference in the position types between the 2 groups (all P > .05). The smooth margin was more common in the noninvasion group (53.1% vs 15.6%, P < .01). The deep lobulated type and the saw tooth sign were more common in the invasion group (57.8% vs 7.1%; and 40.0% vs 6.2%; both P < .01). The deep lobulated (OR = 2.03, 95%CI: 1.21–3.39, P = .007) and saw tooth (OR = 1.036, 95%CI: 1.008–1.065, P = .011) signs were independently associated with renal capsule invasion.Smooth tumor margin suggests the absence of renal capsule invasion, while the deep lobulated and the saw tooth signs strongly suggest the presence of renal capsule invasion in patients with RCC.

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Arterial spin labelling MRI for detecting pseudocapsule defects and predicting renal capsule invasion in renal cell carcinoma

Cited by 7 publications

References 28 publications

Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities

Non-Invasive Renal Perfusion Imaging Using Arterial Spin Labeling MRI: Challenges and Opportunities

Accuracy of magnetic resonance imaging to identify pseudocapsule invasion in renal tumors

Multislice spiral computed tomography signs of invasion of the renal capsule by renal cell carcinoma

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