Arterial stiffness is associated with low skeletal muscle mass in <scp>J</scp>apanese community‐dwelling older adults

Sampaio, Ricardo Aurélio Carvalho; Sampaio, Priscila Yukari Sewo; Yamada, Minoru; Yukutake, Taiki; Uchida, Masayuki; Tsuboyama, Tadao; Arai, Hidenori

doi:10.1111/ggi.12206

Cited by 75 publications

(69 citation statements)

References 28 publications

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“…Association b e t w e e n UCr and high baPWV measured by BIA was inversely associated with the radial augmentation index in men [20]. Sampaio et al also found an association between a low skeletal muscle mass index by BIA and a cardio-ankle vascular index in community-dwelling older adults [21]. Only a few studies have assessed the relationship between muscle mass and arterial stiffness in CKD patients, and those studies have only considered patients on hemodialysis (HD).…”

Section: Discussionmentioning

confidence: 99%

Association between Urine Creatinine Excretion and Arterial Stiffness in Chronic Kidney Disease: Data from the KNOW-CKD Study

Hyun

Kim

Sung

et al. 2016

Kidney Blood Press Res

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Background/Aims: Previous studies have shown that low muscle mass is associated with arterial stiffness, as measured by pulse wave velocity (PWV), in a population without chronic kidney disease (CKD). This link between low muscle mass and arterial stiffness may explain why patients with CKD have poor cardiovascular outcomes. However, the association between muscle mass and arterial stiffness in CKD patients is not well known. Methods: Between 2011 and 2013, 1,529 CKD patients were enrolled in the prospective Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD). We analyzed 888 participants from this cohort who underwent measurements of 24-hr urinary creatinine excretion (UCr) and brachial-ankle PWV (baPWV) at baseline examination. The mean of the right and left baPWV (mPWV) was used as a marker of arterial stiffness. Results: The baPWV values varied according to the UCr quartile (1,630±412, 1,544±387, 1,527±282 and 1,406±246 for the 1st to 4th quartiles of UCr, respectively, P<0.001). For each 100 mg/d increase in UCr, baPWV decreased by 6m/sec in a multivariable linear regression model fully adjusted for traditional and renal cardiovascular risk factors. The odds ratio of the 1st quartile for high baPWV (highest quintile of mPWV) compared with the 4th quartile was 2.62 (1.24-5.54, P=0.011) in a logistic model fully adjusted for traditional and renal cardiovascular risk factors. Conclusion: Low muscle mass estimated by low UCr was associated high baPWV in pre-dialysis CKD patients in Korea. Further studies are needed to confirm the causal relationship between UCR and baPWV, and the role of muscle mass in the development of cardiovascular disease in CKD.

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Section: Discussionmentioning

confidence: 99%

Association between Urine Creatinine Excretion and Arterial Stiffness in Chronic Kidney Disease: Data from the KNOW-CKD Study

Hyun

Kim

Sung

et al. 2016

Kidney Blood Press Res

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“…Investigation into the risk factors and associated factors of muscle mass decline has been ongoing for several decades. Many of the risk factors assessed for declines in muscle mass, summarized in Table , include chronic conditions, such as diabetes, heart disease and hyperlipidemia; arterial stiffness, malnutrition and hematological factors . Several hematological components have been linked to the loss of muscle mass, such as high creatinine, and high albumin concentration had protective effects .…”

Section: Risk Factors Of Sarcopenia Componentsmentioning

confidence: 99%

Sarcopenia: Prevalence and associated factors based on different suggested definitions in community‐dwelling older adults

Kim

Hirano

Edahiro

et al. 2016

Geriatrics Gerontology Int

143

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The age-related loss of muscle mass and/or strength and performance, sarcopenia, has been associated with geriatric syndromes, morbidity and mortality. Although sarcopenia has been researched for many years, currently there is a lack of consensus on its definition. Some studies define sarcopenia as low muscle mass alone, whereas other studies have recently combined low muscle mass, strength and physical performance suggested by the European Working Group on Sarcopenia in Older People, as well as the Asian Working Group for Sarcopenia. The arbitrary use of various available sarcopenia definitions within the literature can cause discrepancies in the prevalence and associated risk factors. The application of population-specific cut-off values in any sample population can be problematic, particularly among different ethnicities. Using commonly used cut-off points to define sarcopenia, including solely muscle mass and combined definitions, on a community-dwelling elderly Japanese population, the prevalence of sarcopenia ranged from 2.5 to 28.0% in men and 2.3 to 11.7% in women, with muscle mass measured by dual-energy X-ray absorptiometry, and 7.1-98.0% in men and 19.8-88.0% in women measured by bioelectrical impedance analysis. Body mass index was the most prominent related factor for sarcopenia across the definitions in this Japanese sample. However, other associated hematological and chronic condition factors varied depending on the definition.

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“…Sarcopenia, the age‐related loss of muscle mass, is defined by reduced appendicular skeletal muscle mass (ASM) relative to height (ASMI) . Sarcopenia and low‐ASMI (pre‐sarcopenia) are associated with increased arterial stiffness (pulse wave velocity, PWV) and wave reflection (augmentation index, AIx) . Arterial stiffening contributes to higher prevalence of systolic hypertension in postmenopausal women via increased wave reflection, which is a major determinant of aortic pulse pressure (aPP) .…”

Section: Participant Characteristics At Baseline In the Low‐asmi And mentioning

confidence: 99%

Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women

Figueroa

Alvarez-Alvarado

Jaime

et al. 2016

Clin Exp Pharma Physio

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Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height (ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI) are exaggerated in older prehypertensives and hypertensives. We examined peripheral and aortic haemodynamics at rest and during PEMI in postmenopausal women with low-ASMI and normal-ASMI. Resting radial AIx and baPWV as well as brachial and aortic systolic BP, pulse pressure, systolic time index, and subendocardial viability ratio (SEVR) responses to PEMI were greater in women with low-ASMI than normal-ASMI. Increased baPWV associated with low-ASMI may play a major role in the exaggerated pulse pressure and SEVR responses to PEMI in postmenopausal women.

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Arterial stiffness is associated with low skeletal muscle mass in Japanese community‐dwelling older adults

Cited by 75 publications

References 28 publications

Association between Urine Creatinine Excretion and Arterial Stiffness in Chronic Kidney Disease: Data from the KNOW-CKD Study

Association between Urine Creatinine Excretion and Arterial Stiffness in Chronic Kidney Disease: Data from the KNOW-CKD Study

Sarcopenia: Prevalence and associated factors based on different suggested definitions in community‐dwelling older adults

Influence of low and normal appendicular lean mass on central blood pressure and wave reflection responses to muscle metaboreflex activation in postmenopausal women

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