Arterial Stiffness Preceding Diabetes

Zheng, Mengyi; Zhang, Xinyuan; Chen, Shuohua; Song, Yanpeng; Zhao, Qin; Gao, Xiang; Wu, Shouling

doi:10.1161/circresaha.120.317950

Cited by 161 publications

(161 citation statements)

References 42 publications

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“…Briefly, from June 2006 to October 2007, participants from Kailuan community were enrolled and completed the first survey including questionnaires, physical examinations, and laboratory assessments, with an every 2-year follow-up. Since the third survey in 2010, a subcohort of the nested study on vascular health was conducted, with the baPWV tests to assess the health status of artery wall [ 22 ]. In this study, we included participants according to the following criteria: (1) individuals participated in at least one survey in 2010–2011, 2012–2013, 2014–2015, or 2016–2017, and received the first baPWV test; (2) individuals had complete baseline data of FBG and TG.…”

Section: Methodsmentioning

confidence: 99%

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Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study

et al. 2021

Cardiovasc Diabetol

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Background Triglyceride–glucose (TyG) index, a simple surrogate marker of insulin resistance, has been reported to be associated with arterial stiffness. However, previous studies were limited by the cross-sectional design. The purpose of this study was to explore the longitudinal association between TyG index and progression of arterial stiffness. Methods A total of 6028 participants were derived from the Kailuan study. TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Arterial stiffness progression was assessed by the annual growth rate of repeatedly measured baPWV. Multivariate linear regression models were used to estimate the cross-sectional association of TyG index with baPWV, and Cox proportional hazard models were used to investigate the longitudinal association between TyG index and the risk of arterial stiffness. Results Multivariate linear regression analyses showed that each one unit increase in the TyG index was associated with a 39 cm/s increment (95%CI, 29–48 cm/s, P < 0.001) in baseline baPWV and a 0.29 percent/year increment (95%CI, 0.17–0.42 percent/year, P < 0.001) in the annual growth rate of baPWV. During 26,839 person-years of follow-up, there were 883 incident cases with arterial stiffness. Participants in the highest quartile of TyG index had a 58% higher risk of arterial stiffness (HR, 1.58; 95%CI, 1.25–2.01, P < 0.001), as compared with those in the lowest quartile of TyG index. Additionally, restricted cubic spline analysis showed a significant dose–response relationship between TyG index and the risk of arterial stiffness (P non-linearity = 0.005). Conclusion Participants with a higher TyG index were more likely to have a higher risk of arterial stiffness. Subjects with a higher TyG index should be aware of the following risk of arterial stiffness progression, so as to establish lifestyle changes at an early stage.

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Section: Methodsmentioning

confidence: 99%

“…BaPWV was measured by a BP-203 RPE III networked arterial stiffness detection device (Omron Health Medical [China]Co., LTD), as detailed elsewhere [ 22 , 25 , 26 ]. Measurements were repeated twice for each participant at a 5 min interval, with the second data considered the final value.…”

Section: Methodsmentioning

confidence: 99%

Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study

et al. 2021

Cardiovasc Diabetol

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110

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“…Then we classified subjects into two subgroups: those who decreased their quartile distribution or persisted within the two lower quartile groups, and those who increased their quartile distribution or persisted within the two higher quartile groups [15]. Outcome 2: a cutoff value of more than 1400 cm/s for baPWV was used to diagnose elevated baPWV [4,[16][17][18]. Individuals with normal baseline baPWV were divided into nonelevated baPWV and incident elevated baPWV groups based on their follow-up baPWV levels.…”

Section: Arterial Stiffness Measurements At Baseline and Follow-up Anmentioning

confidence: 99%

Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression

Sang

Cao

et al. 2021

BMC Cardiovasc Disord

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Background Dyslipidemia contributes to the development and progression of arterial stiffness. We aimed to identify the most informative measures of serum lipids and their calculated ratios in terms of arterial stiffness progression risk. Methods Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and brachial-ankle pulse wave velocity (baPWV) of 659 healthy males (47.4 ± 10.7 years) were measured at baseline. Values for non-HDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C were calculated. BaPWV was re-performed after 4.1 years follow-up. Elevated baPWV was defined as baPWV ≥ 1400 cm/s. Results Over the follow-up period, the mean baPWV value increased from 1340 cm/s to 1410 cm/s, and 331 individuals increased/persisted with high baPWV (outcome 1). Among the 448 subjects who had normal baseline baPWV, 100 incident elevated baPWV occurred (outcome 2). Only baseline logTG (OR 1.64 [95% CI: 1.14–2.37] for outcome 1; 1.89 [1.14–3.17] for outcome 2) and logTG/HDL-C (1.54 [1.15–2.10] for outcome 1; 1.60 [1.05–2.45] for outcome 2) were significantly associated with arterial stiffness progression after adjusting for confounding factors. Adding logTG or logTG/HDL-C to age and blood pressure improved the accuracy of risk predictions for arterial stiffness progression. These associations remained significant when lipids were analyzed as categorical variables. Conclusions Baseline serum TG and TG/HDL-C were independently associated with increases in/persistently high baPWV and incident elevated baPWV, and they performed more effectively than other lipid variables in identifying healthy men at high risk of arterial stiffness progression.

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“…Specially trained nurses used the BP-203 RPE III networked arterial stiffness detection device (Omron Health Medical [China] Co., Ltd.), as previously described [19,20], and measurement of baPWV, BP, and HR was performed before and after the two-stage load test in all subjects. For the rst measurement, participants in light clothes had not been smoking and were seated for at least 15 minutes in a room with the temperature controlled between 22°C and 25°C.…”

Section: Measurement Of Bapwv Bp and Hrmentioning

confidence: 99%

Short-Term Effect of Acute Aerobic Exercise On Arterial Stiffness in People with Different Smoking Statuses

Wang¹,

Huang²,

Zang³

et al. 2021

Preprint

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Background Smoking is strongly associated with arterial stiffness. Long-term regular aerobic exercise is an effective lifestyle intervention that improve arterial stiffness in healthy young people, however, the results of research on the immediate effect of short-term aerobic exercise on arterial stiffness in individuals with different smoking statuses have been inconsistent. The purpose of this study was to investigate the immediate effects of acute aerobic exercise on arterial stiffness in people with different smoking statuses. Method: People who participated in the sixth follow-up visit of the Kailuan Study (trial registration number: ChiCTR-TNRC-11001489) and participated in the fifth National Physical Fitness Monitoring were selected as subjects. All participants completed measurements of brachial–ankle pulse wave velocity, blood pressure, and heart rate before and after a two-stage load test on a power bicycle. The generalized linear model was established to analyze between-group differences in the change in brachial–ankle pulse wave velocity before and after aerobic exercise in people with different smoking statuses. Results There was a total of 940 male participants (36.82 ± 7.76 years old). On the basis of the smoking status, the subjects were divided into the following four groups: never smokers (n = 231), former smokers (n = 165), low-intensity smokers (n = 254), and high-intensity smokers (n = 290). After the two-stage load test, brachial–ankle pulse wave velocity was immediately decreased overall (1375.08 ± 209.09 vs. 1341.53 ± 208.04 cm/s, P < 0.05). The generalized linear model showed that after adjusting for confounding factors, the β-values and 95% confidence intervals of former smokers, low-intensity smokers, and high-intensity smokers were − 12.17 (− 30.08, 5.75), − 18.43 (− 34.69, − 2.16), and − 22.46 (− 38.39, − 6.54) cm/s compared with never smokers, respectively. Conclusion Our results suggest that a single short-term aerobic exercise can immediately improve arterial stiffness in people with different smoking statuses. and clinicians must prescribe individualized exercises for different groups of people to improve arterial stiffness, and reduce the damage to blood vessels caused by smoking.

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Arterial Stiffness Preceding Diabetes

Cited by 161 publications

References 42 publications

Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study

Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study

Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression

Short-Term Effect of Acute Aerobic Exercise On Arterial Stiffness in People with Different Smoking Statuses

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