Arthrocentesis with or without additional drugs in temporomandibular joint internal derangement

Combined Platelet-Rich Plasma and Hyaluronic Acid can Reduce Pain in Patients Undergoing Arthrocentesis for Temporomandibular Joint Osteoarthritis

“…6,9 Nonetheless, our patients received only 1 session of PRP injections, regarding the fact that recent clinical trials advocate only single-session intrajoint injections. 2,8,9 A total of 30 patients were enrolled in the present study, which was similar to the sample size of Kilic et al study and smaller than studies conducted by Giraddi et al, Yousef et al, Marzook et al, Rajput et al, and Hanci et al 7,13,16,25,29,30 In the present study, outcome variables were evaluated prior to treatment and at 1 and 6 months post-treatment. These time intervals were also selected for clinical evaluation in studies by Giraddi et al, Kilic et al, Hassan et al, Hegab et al, and Singh et al [5][6][7]9,14,29,31 Each treatment group demonstrated significant changes in pain intensity values and MMO measurements from baseline till 1 and 6 months postoperatively.…”

“…Insufficient levels of serum-HA have been reported in degenerative joint diseases. 6,8,17,18,25 Intraarticular injection of HA is now a highly accepted and broadly applied treatment protocol for TMJ-OA and provides a reduction in pain and improved jaw function. Despite the extensive research, HA mechanism of action still remains ill-defined.…”

“…Some authorities attribute its healing effect to increasing the viscosity of the synovial fluid and thus providing nutrition to the joint and decreasing inflammatory mediator concentration levels. 2,6,8,11,12,17,18,25 PRP contains up to 3-times to 8-times greater concentrations of platelets than blood plasma. Normal platelet count is 200,000/mL 2 , whereas 2,000,000 ml 2 platelet count is seen in PRP samples.…”

“…Inactivated PRP can cause mesenchymal stem cell proliferation and also induce osteocyte and chondrocyte differentiation. 6,7,9,13,19,25,26 The role of PRP in repairing osteoarthritic TMJs was investigated in a study by Kutuk et al This study was performed on rabbits. 19 Bilateral surgical defects were created in the TMJs and PRP was injected into the right joints, whereas the physiologic saline was applied to the left side.…”