Arthroscopic Knee Surgery Does Not Modify Hyperalgesic Responses to Heat Injury

Werner, Mads U.; Duun, Preben; Kraemer, Otto; Lassen, Birgit; Kehlet, Henrik

doi:10.1097/00000542-200311000-00023

Cited by 9 publications

(17 citation statements)

References 34 publications

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“…The sample size, based on the primary outcome, SHA, was estimated using a significance level of 0.01 (α), counterbalancing for Bonferroni corrections, a power of 0.9 (β = 0.1), a median SHA value of 75 cm 2 , a standard deviation of 18 cm 2 and the inference of a minimal relevant difference of 15 cm 2 and a crossover design . The estimated number of volunteers needed were 16; however, in order to compensate for dropouts, the number of volunteers was set to 19.…”

Section: Methodsmentioning

confidence: 99%

Hyperbaric oxygen therapy attenuates central sensitization induced by a thermal injury in humans

Rasmussen

Borgen

Jansen

et al. 2015

Acta Anaesthesiol Scand

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Section: Methodsmentioning

confidence: 99%

Hyperbaric oxygen therapy attenuates central sensitization induced by a thermal injury in humans

Rasmussen

Borgen

Jansen

et al. 2015

Acta Anaesthesiol Scand

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“…Heat pain threshold (HPT) was assessed using a TSAII NeuroSensory Analyzer (Medoc Ltd, Ramat Yishai, Israel) as previously described 17, 42 with a 16×16 mm stimulator. Use of a 16×16mm stimulator was based on our preliminary work showing more consistent development of temporal summation with this smaller probe size compared to the larger (30×30mm) probe (unpublished).…”

Section: Methodsmentioning

confidence: 99%

A New Transient Sham TENS Device Allows for Investigator Blinding While Delivering a True Placebo Treatment

Rakel

Cooper

Adams

et al. 2010

The Journal of Pain

118

133

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This study compared a new transient sham TENS that delivers current for 45 seconds to an inactive sham and active TENS to determine the degree of blinding and influence on pain reduction. Pressure pain thresholds (PPT), heat pain thresholds (HPT), and pain intensities to tonic heat and pressure were measured in 69 healthy adults before and after randomization. Allocation investigators and subjects were asked to identify the treatment administered. The transient sham blinded investigators 100% of the time and 40% of subjects compared to the inactive sham that blinded investigators 0% of the time and 21% of subjects. Investigators and subjects were only blinded 7% and 13% of the time, respectively, with active TENS. Neither placebo treatment resulted in significant changes in PPT, HPT, or pain intensities. Subjects using higher active TENS amplitudes (≥17mAs) had significantly higher PPTs and lower pain intensities to tonic pressure than subjects using lower amplitudes (<17mAs). HPTs and pain intensities to tonic heat were not significantly changed. The transient TENS completely blinds investigators to treatment and does not reduce pain, thereby providing a true placebo treatment.

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“…In two knee studies, the QST assessments were made either in an experimentally induced burn injury contralateral to the surgery site 22,61 or in the inflammatory changed tissues at the surgery site. 27 This distinction could be important because surgery is associated with profound changes in the inflammatory and nociceptive system leading to pain and hyperalgesia, where abnormal persistence of the nervous system sensitization may lead to the development of chronic postsurgery pain.…”

Section: Preoperative Pain Stimulation Methodsmentioning

confidence: 99%

Prediction of Postoperative Pain

et al. 2010

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Quantitative testing of a patient's basal pain perception before surgery has the potential to be of clinical value if it can accurately predict the magnitude of pain and requirement of analgesics after surgery. This review includes 14 studies that have investigated the correlation between preoperative responses to experimental pain stimuli and clinical postoperative pain and demonstrates that the preoperative pain tests may predict 4-54% of the variance in postoperative pain experience depending on the stimulation methods and the test paradigm used. The predictive strength is much higher than previously reported for single factor analyses of demographics and psychologic factors. In addition, some of these studies indicate that an increase in preoperative pain sensitivity is associated with a high probability of development of sustained postsurgical pain.

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Arthroscopic Knee Surgery Does Not Modify Hyperalgesic Responses to Heat Injury

Abstract: Arthroscopic knee surgery did not modify nociceptive responses to a contralaterally applied experimental burn injury.

Cited by 9 publications

References 34 publications

Hyperbaric oxygen therapy attenuates central sensitization induced by a thermal injury in humans

Hyperbaric oxygen therapy attenuates central sensitization induced by a thermal injury in humans

A New Transient Sham TENS Device Allows for Investigator Blinding While Delivering a True Placebo Treatment

Prediction of Postoperative Pain

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