Arthroscopic optical coherence tomography provides detailed information on articular cartilage lesions in horses

Moller, N.C.R. te; Brommer, Harold; Liukkonen, Jukka; Virén, Tuomas; Timonen, M.; Puhakka, P H; Jurvelin, Jukka S.; Weeren, P. R. van; Töyräs, Juha

doi:10.1016/j.tvjl.2013.05.031

Cited by 27 publications

(31 citation statements)

References 40 publications

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“…This was also seen in a recent equine study where OCT arthroscopies were conducted by insertion of a thin flexible catheter in the metacarpophalangeal joint [12]. In addition, arthroscopically inaccessible areas could be reached by the OCT catheter in some cases.…”

Section: Introductionmentioning

confidence: 58%

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Application of optical coherence tomography enhances reproducibility of arthroscopic evaluation of equine joints

et al. 2014

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BackgroundArthroscopy is widely used in various equine joints for diagnostic and surgical purposes. However, accuracy of defining the extent of cartilage lesions and reproducibility in grading of lesions are not optimal. Therefore, there is a need for new, more quantitative arthroscopic methods. Arthroscopic optical coherence tomography (OCT) imaging is a promising tool introduced for quantitative detection of cartilage degeneration and scoring of the severity of chondral lesions. The aim of this study was to evaluate the inter-investigator agreement and inter-method agreement in grading cartilage lesions by means of conventional arthroscopy and with OCT technique. For this aim, 41 cartilage lesions based on findings in conventional and OCT arthroscopy in 14 equine joints were imaged, blind coded and independently ICRS (International Cartilage Repair Society) scored by three surgeons and one PhD-student.ResultsThe intra- and inter-investigator percentages of agreement by means of OCT (68.9% and 43.9%, respectively) were higher than those based on conventional arthroscopic imaging (56.7% and 31.7%, respectively). The intra-investigator Kappa coefficients were 0.709 and 0.565 for OCT and arthroscopy, respectively. Inter-investigator Kappa coefficients were 0.538 and 0.408 for OCT and arthroscopy, respectively.ConclusionsOCT can enhance reproducibility of arthroscopic evaluation of equine joints.

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Section: Introductionmentioning

confidence: 58%

“…In addition to more reproducible ICRS scoring, cross-sectional OCT images allow detection and classification of subsurface lesions [12]. Furthermore, OCT images have been shown to correspond well to histology of cartilage.…”

Section: Discussionmentioning

confidence: 99%

Application of optical coherence tomography enhances reproducibility of arthroscopic evaluation of equine joints

et al. 2014

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“…46, 99, 100, 113, 134, 162 In addition, OCT is sensitive to collagen orientation and fibrillation, which makes it well suited for evaluating osteoarthritic and repaired tissue. 29, 34, 60, 92, 162 Using OCT areas of fibro-cartilage that are indicative of attempted but inadequate repair have been identified, although these might not be observed on visual arthroscopic examination of a joint. 34, 60 Using OCT, differences in the ultrastructural features of regenerated cartilage, and the integration of host and regenerated tissue have been evaluated.…”

Section: Optical Coherence Tomography (Oct Table 4)mentioning

confidence: 99%

Nondestructive Techniques to Evaluate the Characteristics and Development of Engineered Cartilage

2016

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In this review, methods for evaluating the properties of tissue engineered (TE) cartilage are described. Many of these have been developed for evaluating properties of native and osteoarthritic articular cartilage. However, with the increasing interest in engineering cartilage, specialized methods are needed for nondestructive evaluation of tissue while it is developing and after it is implanted. Such methods are needed, in part, due to the large inter- and intra-donor variability in the performance of the cellular component of the tissue, which remains a barrier to delivering reliable TE cartilage for implantation. Using conventional destructive tests, such variability makes it near-impossible to predict the timing and outcome of the tissue engineering process at the level of a specific piece of engineered tissue and also makes it difficult to assess the impact of changing tissue engineering regimens. While it is clear that the true test of engineered cartilage is its performance after it is implanted, correlation of pre and post implantation properties determined non-destructively in vitro and/or in vivo with performance should lead to predictive methods to improve quality-control and to minimize the chances of implanting inferior tissue.

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“…Optical coherence tomography (OCT) is an imaging modality that has recently been investigated to diagnostically assess equine articular cartilage (10,11). Through the measurement of reflection and backscattering of near infrared light, cross-sectional digital images have been produced during arthroscopy with resolutions comparable to that of low-power microscopy (12).…”

Section: Diagnosing Equine Joint Disease and Cartilage Injurymentioning

confidence: 99%

“…Through the measurement of reflection and backscattering of near infrared light, cross-sectional digital images have been produced during arthroscopy with resolutions comparable to that of low-power microscopy (12). When compared to conventional arthroscopy alone, OCT provided additional detailed and quantitative information about the morphology of articular cartilage lesions including cavitation, fibrillation, superficial clefts and fragmentation that were previously only partially detected (11). The small diameter of the OCT probe has also been shown to make previous arthroscopically inaccessible areas reachable, making it an especially exciting modality for the early detection of equine cartilage lesions (11).…”

Section: Diagnosing Equine Joint Disease and Cartilage Injurymentioning

confidence: 99%

Cartilage Therapy and Repair in Equine Athletes

Johnson

Frisbie

2016

Operative Techniques in Orthopaedics

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Arthroscopic optical coherence tomography provides detailed information on articular cartilage lesions in horses

Cited by 27 publications

References 40 publications

Application of optical coherence tomography enhances reproducibility of arthroscopic evaluation of equine joints

Application of optical coherence tomography enhances reproducibility of arthroscopic evaluation of equine joints

Nondestructive Techniques to Evaluate the Characteristics and Development of Engineered Cartilage

Cartilage Therapy and Repair in Equine Athletes

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