The results of conservative treatment of displaced proximal humerus fractures are not satisfactory. Open reconstruction and rigid internal fixation, as well as arthroscopic-assisted reduction and internal fixation, are possible in selected cases, mostly young patients. Older patients with osteoporotic, comminuted bone accounts for 70% of the cases. We present an arthroscopic reduction and transosseous suture fixation technique for osteoporotic patients with displaced 2-part greater tuberosity fractures of the proximal humerus. The technique reduces the upward and medially displaced greater tuberosity to its anatomic position and uses longitudinal, horizontal, or a mattress suture fixation as single or combined fixation (Natofix technique).