Arthrospira platensis accelerates the formation of an endothelial cell monolayer and protects against endothelial cell detachment after bacterial contamination

Abstract

Within the last years a comprehensive number of scientific studies demonstrated beneficial effect of Arthropira platensis (AP) as dietary supplement due to a high content of proteins, minerals and vitamins. Positive effects like promoting the immune system, reducing inflammation and an anti-oxidant capacity are reported. In this study, the effect of an aqueous AP extract on primary human venous endothelial cells (HUVEC) was investigated. In addition, the effect of AP on HUVEC treated with a bacterial toxin (lipopolysaccharide, LPA), inducing an activation of HUVEC and cellular detachment, was analyzed. Depending on the concentration of AP extract a significantly accelerated formation of an endothelial cell monolayer was observed. Furthermore, the detachment of HUVEC after LPA addition was dramatically reduced by AP. In conclusion, the data are promising and indicatory for an application of Arthrospira platensis in the clinical field.

Influence of Different Light-Emitting Diode Colors on Growth and Phycobiliprotein Generation of Arthrospira platensis

“…The cyanobacterium is generally considered safe as a food by the European Food Safety Authority (EFSA) [ 15 ]. In addition, AP contains an abundant source of different classes of ingredients [ 18 ] of interest for nutraceutical applications [ 19 , 20 , 21 ] or even as pharmaceuticals with potential biological effects on tissue or blood cells [ 22 , 23 , 24 , 25 ]. Due to the very alkaline pH, AP cultures can be maintained without the supplementation of biocide treatments in the growth medium, which is a clear advantage with respect to food safety and environmental issues.…”