Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment

El-Deen, Shaimaa Ahmed Sharaf; Brakat, Reham Mustafa; Mohamed, Asmaa S.

doi:10.1016/j.exppara.2017.05.005

Cited by 12 publications

(5 citation statements)

References 38 publications

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“…The other plants were Mitracarpus frigidus [ 40 ], Ozoroa pulcherrima [ 41 ], Calotropis procera [ 42 ], Ficus elastica [ 42 ], Zingiber officinale [ 42 ], Punica granatum [ 43 ], Tanacetum vulgare [ 44 ], Allium sativum (garlic) [ 45 ], Allium cepa (onion) [ 45 ], Echinops kebericho [ 46 ], Hagenia abyssinica [ 46 ], Ageratum conyzoides , Alchornea cordifolia , Aloe vera , Alstonia boonei , Anthocleista nobilis , Combretum sp, Khaya senegalensis , Mangifera indica , Mitragyna stipulosa , Momordica charantia , Paulina pinnata , Phyllanthus niruri , Picralima nitida , Smeathmannia sp, Syzygium aromaticum , Tapinanthus bangwensis , Taraxacum officinale , Trichila monadelpha and Xylopia aethiopica [ 35 ], Arctium lappa [ 47 ], Baccharis trimera [ 48 ], Cynara scolymus [ 49 ], Ekebergia capensis [ 37 ], Chenopodium ambrosioides [ 50 ], Conyza dioscorides [ 50 ], and Sesbania sesban [ 50 ].…”

Section: Resultsunclassified

“…The only apparent negative reports or perhaps partial potency or toxicity of the plant extracts were those by two studies from Egypt. Leaf ethanol extract of C. scolymus did not exhibit significant effects on worm or tissue egg load and granuloma number in vivo although it caused a significant reduction of granuloma diameter and improvement of liver functions and liver fibrosis [ 49 ]. Furthermore, a study from Egypt [ 42 ] reported that C. procera latex and flower extracts were toxic, and Z. officinale extract did not significantly decrease worm load though after removal of the toxic rubber extract significantly reduced adult worm burden and tissue egg count and positively affected the oogram pattern.…”

Section: Resultsmentioning

confidence: 99%

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The Activity of Plant Crude Extracts against Schistosoma mansoni

Basha

Mamo

2021

Journal of Parasitology Research

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Background. Schistosoma mansoni remains a significant health problem in low-income countries. Praziquantel (PZQ) is the only drug available to treat schistosomiasis, and PZQ resistance is a potential threat towards control of the disease although PZQ is currently effective against all species of schistosomes. Moreover, PZQ is less efficacious against larval stages. In response to these challenges, multiple in vivo/in vitro studies evaluated the anti-S. mansoni activity of crude plant extracts in a bid for novel drug(s). However, these studies appear fragmented and patchy. This systematic review explored the extent of such studies in the past 11 years (2010-2020). Methods. A systematic web search analysis and review of the literature on crude plant extracts tested against S. mansoni was done. Data from 17 articles meeting eligibility criteria were extracted and analyzed. Forty-three plant species have been tested by the 17 studies. The leaves, barks, stems, flowers, rhizomes, and roots of the plants as well as the whole plant part were used for the experiments. Conclusion. Nearly all of the plants significantly reduced schistosome egg output, killed adult worms, and improved liver histology and function. Further studies are required to assess the therapeutic potential of more promising plant species.

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Section: Resultsunclassified

Section: Resultsmentioning

confidence: 99%

The Activity of Plant Crude Extracts against Schistosoma mansoni

Basha

Mamo

2021

Journal of Parasitology Research

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“…It presents several health benefits derived mostly from its high concentration of antioxidant components such as inulin and polyphenols such as caffeic acid derivates, luteolin, and cymaroside [1,9,[31][32][33]. This plant has been shown in several studies to have the capability of being hepatoprotective, antioxidative, anticarcinogenic, antibacterial, anti-HIV, bile-expelling, urinative activities, an inhibitor of cholesterol biosynthesis, and low-density lipoprotein (LDL) oxidation [7,9,31,34,35].…”

Section: Discussionmentioning

confidence: 99%

Effect of Cynara cardunculus L. var. altilis (DC) in Inflammatory Bowel Disease

et al. 2021

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Background: Cynara cardunculus L. var. altilis (DC) is a plant generally associated as an ingredient in the Mediterranean diet. The polyphenols present in this plant provide pharmacological and nutritional properties. C. cardunculus L. has been used throughout animal studies, which demonstrated an anti-inflammatory effect. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Since there is not a known cure, the research of new possible pharmacological approaches is essential. This study aims to evaluate the effect of an aqueous extract of C. cardunculus L. dry leaves in a 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis model. Methods: CD-1 mice with TNBS-induced colitis received an intraperitoneal (IP) administration of C. cardunculus L. once per day for 4 days. Results: The C. cardunculus L. demonstrated a beneficial effect in this experimental model of IBD with anti-inflammatory action through the reduction of tumor necrosis factor (TNF)-α levels. It also demonstrated a beneficial influence on the extra-intestinal manifestations related to IBD, with the absence of significant side effects of its use. Conclusions: The extract of C. cardunculus L. dry leaves can become an interesting tool for new possible pharmacological approaches in the management of IBD.

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“…Sharaf EL‐Deen et al (2017), researched the antiparasitic and hepatoprotective properties of artichoke leaf extract (ALE) on mice experimentally infected with S mansoni and compared its effectiveness to praziquantel (PZQ). He concluded that despite failure of ALE to treat S mansoni infection it could limit liver damage by said parasite by modulating hepatic stellate cell recruitment 11 …”

Section: Discussionmentioning

confidence: 99%