Article Reviewing Transdermal Drug Delivery System

Abstract

Topically applied pharmaceuticals in the form of patches that distribute medications for systemic effects at predefined and controlled rates are known as "transdermal drug delivery systems." The main function of TDDS is penetration of drug through skin. It works extremely simple, with the medicine being put within the patch and is placed on the skin. As a result, a consistent concentration of medication remains in the bloodstream for an extended period. They come in variety of forms, including single-layer drugs in adhesives; inter drugs in adhesives, buffers, and matrix systems. The market price of TDDS products is rapidly expanding. More than 35 items have now been authorized for sale in the United States, and roughly 16 active substances have been approved for usage as a TDDS globally. It is a drug delivery system that has a bright future. It helps in reducing use of syringes for administering a wide range of drugs, but the price is an essential aspect to consider because developing countries like India have the world's second-largest population, but TDDS is a secret part of treatment used for the general population due to rising costs. This review article on transdermal drug delivery systems (TDDS) contains information on the transdermal drug delivery system, Advanced development and the evaluation procedure.
 Keywords: TDDS, Drug penetration, Bright future, Rising costs, Evaluation procedure.

A systemic review on development of mesoporous nanoparticles as a vehicle for transdermal drug delivery

“…There has recently been a surge of interest in novel drug delivery systems for existing drug molecules. The novel drug delivery system improves patient compliance while increasing the safety and efficiency of a drug molecule 1 . Dermal (topical) drug delivery is used to define localized action to the pathological sites within the skin with minimal systemic absorption.…”

“…The following characteristics should be present in an ideal drug candidate for transdermal drug delivery 1 :…”

“…This is the skin's outermost layer, also known as the horny layer, and has a thickness of about 0.8 mm 1 . From the inside to the outside, the epidermis has five layers: the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum (SC) 5 .…”

“…The epidermis is organized in the form of 'bricks' and 'mortar', with protein-rich keratinocytes acting as 'bricks' and intercellular lipids acting as 'mortar' 4 . The stratum corneum, which is composed of metabolically active agents such as mitochondria and ribosomes, serves as the primary barrier to drug penetration 1 , 3 - 5 , 11 .…”

A Simple Glance at the Transdermal Drug Delivery System

“…TDDS has piqued attention as a viable alternative to oral medications and hypodermic injections [1]. When especially in comparison to oral or systemic dosing strategies, TDDS allows for sustained release of the drug into patients, minimizing Hepatic first-pass biotransformation effects, lessening systemic adverse outcomes, enhancing dose efficiency during entire treatment by allowing for consistent blood drug profiles, and better patient adherence.…”