Artificial exstrophy in the dog for separated renal function studies

Fein, Richard L.

doi:10.1016/0022-4804(69)90059-6

Cited by 5 publications

(2 citation statements)

References 4 publications

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“…Apart from the models mentioned previously (Muecke, 1964; Thomalla et al, 1985) CBE was also created in lambs by infraumbilical incision (Slaughenhoupt et al, 1996). The embryology of CBE was further studied in a rat model (Mildenberger et al, 1988), and artificial exstrophy in female dogs was used to study renal function separately (Fein, 1969).…”

Section: Discussionmentioning

confidence: 99%

Bladder exstrophy‐epispadias complex

Ludwig

Ching

Reutter

et al. 2009

Birth Defects Research

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The bladder exstrophy-epispadias complex (BEEC) represents an anterior midline defect with variable expression comprising a spectrum of anomalies involving the abdominal wall, pelvis, urinary tract, genitalia, and occasionally the spine and anus. The vast majority of BEEC cases are classified as non-syndromic and the etiology of this malformation is still unknown. This review presents the current state of knowledge on this multifactorial disorder, including historical retrospect, phenotypic and anatomical characterization, epidemiology, proposed developmental mechanisms, existing animal models, and implicated genetic and environmental components. These published lines of evidence argue strongly that BEEC occurs as a result of strong genetic predisposition that is yet to be deciphered.

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Section: Discussionmentioning

confidence: 99%

Bladder exstrophy‐epispadias complex

Ludwig

Ching

Reutter

et al. 2009

Birth Defects Research

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“…Prior to removing the kidneys, urine specimens were obtained from each ureter to compare sodium, potassium, chloride, osmotic and creatinine concentrations. This protocol was supplemented in a few experiments each as follows: hemorrhagic hypo tension during ammonium infusion; infusion of sodium bicarbonate or sodium sulfate intravenously; and studies of renal function and histology 10-50 days after ammonium in fusion in trigone-explant dogs [5], Pertinent details of these variations will be noted in the results.…”

Section: Methodsmentioning

confidence: 99%

Some Effects of Ammonium Salts on Renal Histology and Function in the Dog

Orvell

Wesson

1976

Nephron

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NH₄CI was infused into the left renal artery of anesthetized dogs at 50–125 µM/kg/min for up to 110 min. Renal blood flow declined early then increased to supra-control levels during infusion. Kidneys perfused at 125 µM/kg/min for 90 min showed patchy to confluent mixtures of cortical necrosis and tubular necrosis. Experimental kidneys invariably showed lower urine osmolality than contralateral controls 48 h after perfusion. Kidneys with necrosis showed depressed creatinine clearance as well. Renal artery infusion of NH4 acetate or intravenous infusion of NaHCO₃ during arterial infusion of NH₄CI prevented significant acidosis and caused minimal histological changes, but depression of urine osmolality was not prevented. It is concluded that renal ammonium concentrations up to 40 µM/liter for 90 min does not cause tubular necrosis but does impair urine concentration. Severe tissue damage followed renal exposure to high ammonium concentrations in the presence of metabolic or renal acidosis.

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The Exstrophy Complex: Bladder and Cloacal Exstrophy

Stuhldreher

Gearhart

2018

Rickham's Neonatal Surgery

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Artificial exstrophy in the dog for separated renal function studies

Cited by 5 publications

References 4 publications

Bladder exstrophy‐epispadias complex

Bladder exstrophy‐epispadias complex

Some Effects of Ammonium Salts on Renal Histology and Function in the Dog

The Exstrophy Complex: Bladder and Cloacal Exstrophy

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