In today's rapidly evolving business landscape, modern enterprises face unprecedented challenges in aligning technology initiatives with strategic goals. This chapter explores the integration of Artificial Intelligence (AI) and Agile methodologies to drive program success and achieve digital transformation. By examining real-world case studies, the chapter highlights how AI-enhanced decision-making, predictive analytics, and automation can be seamlessly integrated into Agile workflows, enhancing flexibility, collaboration, and innovation. The fusion of AI with Agile not only accelerates development cycles but also fosters a data-driven culture, enabling enterprises to respond swiftly to changing market demands. This chapter provides actionable insights and best practices for technology leaders to harness the synergy between AI and Agile methods, ensuring sustainable success in complex, dynamic environments.