Forensic medicine has traditionally relied on conventional autopsy methods for determining the cause of death and supporting criminal investigations. However, the introduction of artificial intelligence (AI) has sparked a new era in forensic medicine, fundamentally altering the autopsy process. This comprehensive review investigates the transformative impact of AI-powered autopsy techniques on forensic medicine, emphasizing the advancements, challenges, and future possibilities. Through a meticulous analysis of current research and case studies, the article illustrates how AI significantly improves accuracy, efficiency, and objectivity in forensic investigations, resulting in more dependable outcomes. The integration of AI into autopsy procedures represents a revolutionary shift in forensic medicine, with emerging technologies and methodologies reshaping investigative practices. Alongside traditional autopsies, the utilization of VIRTOPSY—an advanced imaging technique—is increasingly prominent, further enhancing the forensic examination process. By delving into recent advancements, applications, and potential developments, this review provides a holistic overview of how AI is reshaping forensic investigations, enhancing reliability, and contributing to justice. This review underscores the transformative role of AI in forensic medicine, highlighting its potential to reshape practices and contribute significantly to societal well-being.