Artificial Intelligence in Inflammatory Bowel Disease Endoscopy: Implications for Clinical Trials

Ahmad, Harris; East, James E.; Panaccione, Remo; Travis, Simon; Canavan, James B.; Usiskin, Keith; Byrne, Michael F.

doi:10.1093/ecco-jcc/jjad029

Cited by 17 publications

(16 citation statements)

References 83 publications

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“…In conclusion, the integration of AI in advanced endoscopy holds great promise in IBD 90 . It is expected to revolutionize the assessment of inflammation and improve diagnostic accuracy.…”

Section: Ai‐enabled Endoscopy Precision In Diagnosis and Predictionmentioning

confidence: 97%

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Present and future of endoscopy precision for inflammatory bowel disease

Santacroce,

Zammarchi,

Tan

et al. 2023

Digestive Endoscopy

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Several advanced imaging techniques are now available for endoscopists managing inflammatory bowel disease (IBD) patients. These tools, including dye‐based and virtual chromoendoscopy, probe‐based confocal laser endomicroscopy and endocytoscopy, are increasingly innovative applications in clinical practice. They allow for a more in‐depth and refined evaluation of the mucosal and vascular bowel surface, getting closer to histology. They have demonstrated a remarkable ability in assessing intestinal inflammation, histologic remission, and predicting relapse and favorable long‐term outcomes. In addition, the future application of molecular endoscopy to predict biological drug responses has yielded preliminary but encouraging results. Furthermore, these techniques are crucial in detecting and characterizing IBD‐related dysplasia, assisting endoscopic mucosal resection and submucosal dissection towards a surgery‐sparing approach. Artificial intelligence (AI) holds great potential in this promising landscape, as it can provide an objective and reproducible assessment of inflammation and dysplasia. Moreover, it can improve the prediction of outcomes and aid in subsequent therapeutic decision‐making. This review aims to summarize the promising role of state‐of‐the‐art advanced endoscopic techniques and related AI‐enabled models for managing IBD, paving the way for precision medicine.

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“…In conclusion, the integration of AI in advanced endoscopy holds great promise in IBD 90 . It is expected to revolutionize the assessment of inflammation and improve diagnostic accuracy.…”

Section: Ai‐enabled Endoscopy Precision In Diagnosis and Predictionmentioning

confidence: 97%

“…In conclusion, the integration of AI in advanced endoscopy holds great promise in IBD. 90 It is expected to revolutionize the assessment of inflammation and improve diagnostic accuracy. AI will detect subtle changes that may not be visible to the human eye and reduce interobserver variability.…”

Section: Ai-enabled Prediction Of Ibd-associated Dysplasiamentioning

confidence: 99%

Present and future of endoscopy precision for inflammatory bowel disease

Santacroce,

Zammarchi,

Tan

et al. 2023

Digestive Endoscopy

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“…There has been a recent emerging role of artificial intelligence (AI) in gastroenterology to be able to improve endoscopic disease detection, diagnosis, and severity grading due to high endoscopic inter-rater variability that currently exists[ 35 ]. It has also been proposed as a potential IBD research tool to replace the need for a central endoscopy reader, which could help with the speed of trial completion[ 36 ]. In addition to diagnostic endoscopy, the use of AI to help detect small bowel ulceration and nonobstructive bowel stenosis in video capsule endoscopy is a developing field[ 37 ].…”

Section: Artificial Intelligencementioning

confidence: 99%

Imaging and endoscopic tools in pediatric inflammatory bowel disease: What’s new?

Hudson,

Wahbeh,

Zheng

2024

World J Clin Pediatr

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Pediatric inflammatory bowel disease (IBD) is a chronic inflammatory disorder, with increasing incidence and prevalence worldwide. There have been recent advances in imaging and endoscopic technology for disease diagnosis, treatment, and monitoring. Intestinal ultrasound, including transabdominal, transperineal, and endoscopic, has been emerging for the assessment of transmural bowel inflammation and disease complications (e.g., fistula, abscess). Aside from surgery, IBD-related intestinal strictures now have endoscopic treatment options including through-the-scope balloon dilatation, injection, and needle knife stricturotomy and new evaluation tools such as endoscopic functional lumen imaging probe. Unsedated transnasal endoscopy may have a role in patients with upper gastrointestinal Crohn’s disease or those with IBD with new upper gastrointestinal symptoms. Improvements to dysplasia screening in pediatric patients with longstanding colonic disease or primary sclerosing cholangitis hold promise with the addition of virtual chromoendoscopy and ongoing research in the field of artificial intelligence-assisted endoscopic detection. Artificial intelligence and machine learning is a rapidly evolving field, with goals of further personalizing IBD diagnosis and treatment selection as well as prognostication. This review summarized these advancements, focusing on pediatric patients with IBD.

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“…Two major subtypes of IBD are ulcerative colitis (UC) and Crohn’s disease (CD) ( 2 ). UC is characterized by an inflammation limited to the colon and the rectum, beginning in the rectum and extending to the proximal colon ( 3 , 4 ). In contrast, CD can impact any part of the digestive system, with a particular focus on the terminal ileum.…”

Section: Introductionmentioning

confidence: 99%

Diet-derived circulating antioxidants and risk of inflammatory bowel disease: a Mendelian randomization study and meta-analysis

Zou,

Liang,

Zhang

et al. 2024

Front. Immunol.

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BackgroundPrevious studies have shown conflicting results regarding the impact of circulating antioxidants on the risk of inflammatory bowel disease (IBD). In this study, our intent was to investigate the causal relationship between circulating antioxidants and IBD using Mendelian randomization (MR).MethodsInstrumental variables for absolute circulating antioxidants (ascorbate, retinol, lycopene, and β-carotene) and circulating antioxidant metabolites (α-tocopherol, γ-tocopherol, ascorbate, and retinol) were screened from published studies. We obtained outcome data from two genome-wide association study (GWAS) databases, including the international inflammatory bowel disease genetics consortium (IIBDGC, 14,927 controls and 5,956 cases for Crohn’s disease (CD), 20,464 controls and 6,968 cases for ulcerative colitis (UC), and 21,770 controls and 12,882 cases for IBD) and the FinnGen study (375,445 controls and 1,665 cases for CD, 371,530 controls and 5,034 cases for UC, and 369,652 controls and 7,625 cases for IBD). MR analysis was performed in each of the two databases and those results were pooled using meta-analysis to assess the overall effect of exposure on each phenotype. In order to confirm the strength of the findings, we additionally conducted a replication analysis using the UK Biobank.ResultsIn the meta-analysis of the IIBDGC and FinnGen, we found that each unit increase in absolute circulating level of retinol was associated with a 72% reduction in the risk of UC (OR: 0.28, 95% CI: 0.10 to 0.78, P=0.015). The UC GWAS data from the UK Biobank also confirmed this causal relationship (OR: 0.99, 95% CI: 0.97 to 1.00, P=0.016). In addition, there was suggestive evidence that absolute retinol level was negatively associated with IBD (OR: 0.41, 95% CI: 0.18 to 0.92, P=0.031). No other causal relationship was found.ConclusionOur results provide strong evidence that the absolute circulating level of retinol is associated with a reduction in the risk of UC. Further MR studies with more instrumental variables on circulating antioxidants, especially absolute circulating antioxidants, are needed to confirm our results.

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Artificial Intelligence in Inflammatory Bowel Disease Endoscopy: Implications for Clinical Trials

Cited by 17 publications

References 83 publications

Present and future of endoscopy precision for inflammatory bowel disease

Present and future of endoscopy precision for inflammatory bowel disease

Imaging and endoscopic tools in pediatric inflammatory bowel disease: What’s new?

Diet-derived circulating antioxidants and risk of inflammatory bowel disease: a Mendelian randomization study and meta-analysis

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