Artificial Intelligence in Pathology: Friend or Enemy?

Sevim, Selim; Serbes, Ezgi Dicle; Bahadır, Murat; Kartal, Mustafa Said; Sak, Serpil Dizbay

doi:10.4274/atfm.galenos.2022.78309

Cited by 1 publication

(1 citation statement)

References 35 publications

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“…Similarly, in another study, bone marrows with multiple myeloma involvement and bone marrows without disease could be separated from each other via micro-CT structural parameters, namely bone volume fraction, bone surface to bone volume ratio, and trabecular thickness [32]. In addition, according to the results of an unpublished study conducted by our group, different types of solid patterned lung tumors may differ from each other in terms of some structural parameters [85]. However, there is no published data on the discrimination of different pulmonary tumor types or adenocarcinoma patterns using quantitative parameters obtained via micro-CT or using micro-CT images.…”

Section: Micro-ct Cannot Replace Microscopy In Its Current Capacitymentioning

confidence: 98%

The Value of Micro-CT in the Diagnosis of Lung Carcinoma: A Radio-Histopathological Perspective

Dizbay Sak,

Sevim,

Buyuksungur

et al. 2023

Diagnostics

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Micro-computed tomography (micro-CT) is a relatively new imaging modality and the three-dimensional (3D) images obtained via micro-CT allow researchers to collect both quantitative and qualitative information on various types of samples. Micro-CT could potentially be used to examine human diseases and several studies have been published on this topic in the last decade. In this study, the potential uses of micro-CT in understanding and evaluating lung carcinoma and the relevant studies conducted on lung and other tumors are summarized. Currently, the resolution of benchtop laboratory micro-CT units has not reached the levels that can be obtained with light microscopy, and it is not possible to detect the histopathological features (e.g., tumor type, adenocarcinoma pattern, spread through air spaces) required for lung cancer management. However, its ability to provide 3D images in any plane of section, without disturbing the integrity of the specimen, suggests that it can be used as an auxiliary technique, especially in surgical margin examination, the evaluation of tumor invasion in the entire specimen, and calculation of primary and metastatic tumor volume. Along with future developments in micro-CT technology, it can be expected that the image resolution will gradually improve, the examination time will decrease, and the relevant software will be more user friendly. As a result of these developments, micro-CT may enter pathology laboratories as an auxiliary method in the pathological evaluation of lung tumors. However, the safety, performance, and cost effectiveness of micro-CT in the areas of possible clinical application should be investigated. If micro-CT passes all these tests, it may lead to the convergence of radiology and pathology applications performed independently in separate units today, and the birth of a new type of diagnostician who has equal knowledge of the histological and radiological features of tumors.

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Section: Micro-ct Cannot Replace Microscopy In Its Current Capacitymentioning

confidence: 98%