Artificial intelligence-powered microfluidics for nanomedicine and materials synthesis

Liu, Linbo; Bi, Mingcheng; Wang, Yunhua; Liu, Junfeng; Jiang, Xiwen; Xu, Zhongbin

doi:10.1039/d1nr06195j

Cited by 63 publications

(49 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…utilizing the state-of-the-art 4D printing method to prepare POPs with regulated morphologies. 284 In addition, with the assistance of recently developed deep/machine learning and artificial intelligence technologies, 285–290 it would be much easier to design and evaluate POPs for biomedical applications at an accelerated pace.…”

Section: Discussionmentioning

confidence: 99%

Emerging porous organic polymers for biomedical applications

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Emerging porous organic polymers for biomedical applications

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Microfluidics, also known as “lab-on-a-chip systems”, an emerging technology which represents a revolution in laboratory experimentation, bringing the benefits of integration, miniaturization, and automation, can offer attractive alternatives for current cell culture and handling technologies to advance the current state of microalgal biofuel/bioproduct research. [26, 27]…”

Section: Resultsmentioning

confidence: 99%

“…This work is also an advancement in the field of sustainable Nature/bio-derived materials [43-48]. It can dramatically accelerate the development of renewable and sustainable algal for CO 2 fixation and biosynthesis and related systems for advanced sustainable energy, food, pharmacy, and agriculture with enormous social and ecological benefits [9, 10, 26, 27, 49-55].…”

Section: Resultsmentioning

confidence: 99%

Microfluidic chemostatic bioreactor for high-throughput screening and sustainable co-harvesting of biomass and biodiesel in microalgae

Zheng

Cui

Lü

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

As a renewable and sustainable source for energy, environment, and biomedical applications, microalgae and microalgal biodiesel have attracted great attention. However, their applications are confined due to the cost-efficiency of microalgal mass production. One-step strategy and continuous culturing systems could be solutions. However, current studies for optimization throughout microalgae-based biofuel production pipelines are generally derived from the batch culture process. Better tools are needed to study algal growth kinetics in continuous systems. A microfluidics chemostatic bioreactor array was presented, providing low-adhesion cultivation for algae in the gas, nutrition, and temperature (GNT) well-controlled environment with high throughput. The chip wasused to mimic the continuous culture environment of bioreactors. It allowed simultaneously studying of 8×8 different chemostatic conditions on algal growth and oil production in parallel on a 7×7 cm2 footprint. On-chip experiments of batch and continuous cultures of Chlorella. sp. were performed to study growth and lipid accumulation under different nitrogen concentrations. The results demonstrated that microalgal cultures can be regulated to grow and accumulate lipids concurrently, thus enhancing lipid productivity in one step. The developed on-chip culturing condition screening, which was more suitable for continuous bioreactor, was achieved at a half shorter time, 64-times higher throughput, and less reagent consumption. It could be used to establish chemostat cultures in continuous bioreactors which can dramatically accelerate the development of renewable and sustainable algal for CO2 fixation and biosynthesis and related systems for advanced sustainable energy, food, pharmacy, and agriculture with enormous social and ecological benefits.TEASERSustainable microfluidic bioreactor for 64 times higher-throughput screening CO2 fixation and biomass and biodiesel production in microalgae.

show abstract

“…In this sense, recently studies have used advanced on-chip characterization techniques such as DLS, confocal Raman microscopy, X-ray absorption spectroscopy [209], SAXS [210], and SANS [211] to understand the relationship between microfluidic processes and nanoformulation. Recently, microfluidics has also been associated with artificial intelligence technologies to process a large amount of obtained data in nanomedicine and material synthesis [212].…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Advanced Microfluidic Technologies for Lipid Nano-Microsystems from Synthesis to Biological Application

et al. 2022

View full text Add to dashboard Cite

Microfluidics is an emerging technology that can be employed as a powerful tool for designing lipid nano-microsized structures for biological applications. Those lipid structures can be used as carrying vehicles for a wide range of drugs and genetic materials. Microfluidic technology also allows the design of sustainable processes with less financial demand, while it can be scaled up using parallelization to increase production. From this perspective, this article reviews the recent advances in the synthesis of lipid-based nanostructures through microfluidics (liposomes, lipoplexes, lipid nanoparticles, core-shell nanoparticles, and biomimetic nanovesicles). Besides that, this review describes the recent microfluidic approaches to produce lipid micro-sized structures as giant unilamellar vesicles. New strategies are also described for the controlled release of the lipid payloads using microgels and droplet-based microfluidics. To address the importance of microfluidics for lipid-nanoparticle screening, an overview of how microfluidic systems can be used to mimic the cellular environment is also presented. Future trends and perspectives in designing novel nano and micro scales are also discussed herein.

show abstract

Artificial intelligence-powered microfluidics for nanomedicine and materials synthesis

Abstract: Artificial intelligence-powered microfluidics has greatly promoted the development of nanomedicine and material synthesis.

Cited by 63 publications

References 111 publications

Emerging porous organic polymers for biomedical applications

Emerging porous organic polymers for biomedical applications

Microfluidic chemostatic bioreactor for high-throughput screening and sustainable co-harvesting of biomass and biodiesel in microalgae

Advanced Microfluidic Technologies for Lipid Nano-Microsystems from Synthesis to Biological Application

Contact Info

Product

Resources

About