Artificial M2 macrophages for disease-modifying osteoarthritis therapeutics

Ma, Yandong; Yang, Haolin; Zong, Xiaoqing; Wu, Jinpei; Ji, Xin; Li, Wen; Yuan, Peng; Chen, Xinjie; Yang, Caiqi; Li, Xiaodi; Chen, Yong; Wang, Xue; Dai, Jian

doi:10.1016/j.biomaterials.2021.120865

Cited by 61 publications

(49 citation statements)

References 65 publications

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“…Macrophages can also enhance the angiogenesis of endothelial cells ( Dong et al, 2017 ). It is known that the change in the microenvironment can polarize macrophages in either direction of M1 or M2 ( Ma et al, 2021 ). M1 macrophages can secrete pro-inflammatory cytokines while M2 macrophages take part in tissue remodeling and resolution of inflammation ( Loi et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

3D printing polylactic acid polymer-bioactive glass loaded with bone cement for bone defect in weight-bearing area

Ding

Liu²,

Zhang³

et al. 2022

Front. Bioeng. Biotechnol.

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The treatment of bone defects in weight-bearing areas is mainly to transplant filling materials into the defect area, to provide immediate and strong support for weight-bearing. At present, the commonly used filling material is bone cement, which can only provide physical support without bone regeneration effect. The long-term stress at the interface may cause the loosening of bone cement. The ideal filling material should provide not only strong mechanical support but also promote bone regeneration. We introduce a 3D printing frame-filling structure in this study. The structure was printed with polylactic acid/bioactive glass as the frame, and bone cement as the filler. In this system, bone cement was used to provide immediate fixation, and the frame provided long-term fixation by promoting osteogenic induction and conduction between the interface. The results showed that the degradation of bioactive glass in the frame promoted osteogenic metabolism, induced M2 polarization of macrophages, and inhibited local inflammatory response. The in vivo study revealed that implantation of the frame-filling structure significantly promoted bone regeneration in the femoral bone defect area of New Zealand white rabbits. For a bone defect in a weight-bearing area, long-term stability could be obtained by bone integration through this frame-filling structure.

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Section: Discussionmentioning

confidence: 99%

3D printing polylactic acid polymer-bioactive glass loaded with bone cement for bone defect in weight-bearing area

Ding

Liu²,

Zhang³

et al. 2022

Front. Bioeng. Biotechnol.

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Section: Research Status Of Artificial Cellsmentioning

confidence: 99%

Artificial Cells: Past, Present and Future

Jiang

Zheng

et al. 2022

ACS Nano

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Artificial cells are constructed to imitate natural cells and allow researchers to explore biological process and the origin of life. The construction methods for artificial cells, through both top-down or bottom-up approaches, have achieved great progress over the past decades. Here we present a comprehensive overview on the development of artificial cells and their properties and applications. Artificial cells are derived from lipids, polymers, lipid/polymer hybrids, natural cell membranes, colloidosome, metal−organic frameworks and coacervates. They can be endowed with various functions through the incorporation of proteins and genes on the cell surface or encapsulated inside of the cells. These modulations determine the properties of artificial cells, including producing energy, cell growth, morphology change, division, transmembrane transport, environmental response, motility and chemotaxis. Multiple applications of these artificial cells are discussed here with a focus on therapeutic applications. Artificial cells are used as carriers for materials and information exchange and have been shown to function as targeted delivery systems of personalized drugs. Additionally, artificial cells can function to substitute for cells with impaired function. Enzyme therapy and immunotherapy using artificial cells have been an intense focus of research. Finally, prospects of future development of cell-mimic properties and broader applications are highlighted.

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“…This pentacyclic triterpenoid inhibits NF-𝜅B activation for anti-inflammatory activity. [42] When tested in a Panc02 ectopic xenograft mouse model, these nanoparticles circulated longer, accumulated more at the tumor sites, and inhibited tumor growth better than the uncoated nanoparticle Payload PLGA PTX, [45] rapamycin, [32] DOX, [46] Celastrol, [ 34,47] ICG, [48] membrane-bound gadolinium-lipid, [49] tacrolimus, [28] carfilzomib, [38] PTX, [39] Chitosan or chitosan-gelatine crosslinked polymers atorvastatin, [35] ChS [50] Silk fibroin ferulic acid [51] PEGylated poly(𝛽-amino ester) nanoparticles PTX [52] DOPE/DSPE-PEG liposome emtansine [26] Gold nanoclusters, nanoshell, or nanocage cholorin e6 and indoximod, [53] DOX, [53] cyanine 7 [54] Mesoporous silica IR780 (a photothermal and imaging agent), [55] DOX [ 25,56] Metal-organic framework nanoparticles mitoxantrone and siRNA, [57] glucose oxidase and chloroperoxidase [33] Magnetic nanoclusters simvastatin, [58] siRNA, [59] Gallium nanoswimmers DOX [60] HSA nanoparticles Pt(lau) (a laurate-functionalized Pt(IV) prodrug) [61] Bismuth selenide nanoparticles quercetin [41] a) PLGA = poly(lactic-co-glycolic acid), PTX = paclitaxel, DOX = doxorubicin, ICG = indocyanine green, ChS = chondroitin sulfate, DOPE = 1,2-dioleoyl-sn-glycero-3phoshoethanolamine, DSPE-PEG = distearoylphosphatidylethanolamine-poly(ethylene glycol), siRNA = small interfering RNA, HAS = human serum albumin.…”

Section: Wbc-nps As Carriers For Drug Deliverymentioning

confidence: 99%

“…Since the initial development, different core materials, such as PLGA, [28,32,34,38,39,[45][46][47][48][49] chitosan, [35,50] silk, [51] poly(𝛽amino ester), [52] liposomes, [26] gold nanoparticles, [53,54] mesoporous silica, [25,55,56] MOF nanoparticles, [33,57] and other inorganic nanoparticles, [41,[58][59][60][61] have been coated for the delivery of numerous drug payloads (Table 1). For better drug targeting, researchers introduced additional ligands to the cell membranes through chemical conjugation.…”

Section: Wbc-nps As Carriers For Drug Deliverymentioning

confidence: 99%

White Blood Cell Membrane‐Coated Nanoparticles: Recent Development and Medical Applications

Wang

Zhou

et al. 2021

Adv Healthcare Materials

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White blood cells (WBCs) are immune cells that play essential roles in critical diseases including cancers, infections, and inflammatory disorders. Their dynamic and diverse functions have inspired the development of WBC membrane-coated nanoparticles (denoted "WBC-NPs"), which are formed by fusing the plasma membranes of WBCs, such as macrophages, neutrophils, T cells, and natural killer cells, onto synthetic nanoparticle cores. Inheriting the entire source cell antigens, WBC-NPs act as source cell decoys and simulate their broad biointerfacing properties with intriguing therapeutic potentials. Herein, the recent development and medical applications of WBC-NPs focusing on four areas, including WBC-NPs as carriers for drug delivery, as countermeasures for biological neutralization, as nanovaccines for immune modulation, and as tools for the isolation of circulating tumor cells and fundamental research is reviewed. Overall, the recent development and studies of WBC-NPs have established the platform as versatile nanotherapeutics and tools with broad medical application potentials.

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Artificial M2 macrophages for disease-modifying osteoarthritis therapeutics

Cited by 61 publications

References 65 publications

3D printing polylactic acid polymer-bioactive glass loaded with bone cement for bone defect in weight-bearing area

3D printing polylactic acid polymer-bioactive glass loaded with bone cement for bone defect in weight-bearing area

Artificial Cells: Past, Present and Future

White Blood Cell Membrane‐Coated Nanoparticles: Recent Development and Medical Applications

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