Abstract:miRNAs are a class of noncoding RNAs with gene regulation properties, and they function as key factors in cell homeostasis. The interaction of miRNAs with their target mRNAs is largely considered to rely on sequence complementarity; however, some evidence indicates that mature miRNAs can adopt diverse conformations with implications for their function. Using the oncogenic miR‐181 family as a study model, we suggest that a potential relationship between the primary sequence and secondary structure of miRNAs may… Show more
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