Artificial Phospholipids and Their Vesicles

Zumbuehl, Andreas

doi:10.1021/acs.langmuir.8b02601

Cited by 16 publications

(16 citation statements)

References 112 publications

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“…The position of a fatty acyl chain in sn1 or sn2 increases the diversity further. Thus, the beautiful and large family of phospholipids already contains more than 40,000 natural molecules [ 2 , 9 ]. Precise and structural identification of lipids in a biological medium has been underway for more than 30 years and is becoming possible thanks to the development of mass spectrometry [ 10 ].…”

Section: Basic Concepts On Plsmentioning

confidence: 99%

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Phospholipids: Identification and Implication in Muscle Pathophysiology

Bargui

Solgadi

Prost

et al. 2021

IJMS

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Phospholipids (PLs) are amphiphilic molecules that were essential for life to become cellular. PLs have not only a key role in compartmentation as they are the main components of membrane, but they are also involved in cell signaling, cell metabolism, and even cell pathophysiology. Considered for a long time to simply be structural elements of membranes, phospholipids are increasingly being viewed as sensors of their environment and regulators of many metabolic processes. After presenting their main characteristics, we expose the increasing methods of PL detection and identification that help to understand their key role in life processes. Interest and importance of PL homeostasis is growing as pathogenic variants in genes involved in PL biosynthesis and/or remodeling are linked to human diseases. We here review diseases that involve deregulation of PL homeostasis and present a predominantly muscular phenotype.

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Section: Basic Concepts On Plsmentioning

confidence: 99%

“…[ 1 ]. Of all the different lipids, PLs were indispensable to the appearance of life since they can delimit cellular compartments [ 2 , 3 ]. After presentation of the basic concepts on PLs, we present how to isolate, separate, and identify these molecules.…”

Section: Introductionmentioning

confidence: 99%

Phospholipids: Identification and Implication in Muscle Pathophysiology

Bargui

Solgadi

Prost

et al. 2021

IJMS

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“…Liposomes do not, however, typically improve the selectivity of drug delivery to a target tissue. [27] To address this, multiple strategies are under investigation, including endogenously targeted liposomes (enzymatic digestion, [28] receptor overexpression [29] ), and formulations that are sensitive to external stimuli to promote drug release (e. g., light, [30] ultrasound (US) [31] and mechanical stress [32] ). These potentially offer both spatial and temporal control over drug release, [33] thus enabling a smaller overall dose to be administered, and potentially reducing the side effects of treatment.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound‐Triggered Delivery of Iproplatin from Microbubble‐Conjugated Liposomes

et al. 2021

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The Pt IV prodrug iproplatin has been actively loaded into liposomes using a calcium acetate gradient, achieving a 3‐fold enhancement in drug concentration compared to passive loading strategies. A strain‐promoted cycloaddition reaction (azide‐ dibenzocyclooctyne) was used to attach iproplatin‐loaded liposomes L(Pt) to gas‐filled microbubbles (M), forming an ultrasound‐responsive drug delivery vehicle [M−L(Pt)]. Ultrasound‐triggered release of iproplatin from the microbubble‐liposome construct was evaluated in cellulo. Breast cancer (MCF‐7) cells treated with both free iproplatin and iproplatin‐loaded liposome−microbubbles [M−L(Pt)] demonstrated an increase in platinum concentration when exposed to ultrasound. No appreciable platinum uptake was observed in MCF‐7 cells following treatment with L(Pt) only or L(Pt)+ultrasound, suggesting that microbubble‐mediated ultrasonic release of platinum‐based drugs from liposomal carriers enables greater control over drug delivery.

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“…1 Using artificial phospholipids with a dedicated backbone chemistry and tail length that form interdigitated bilayers, facetted liposomes have been discovered. 2 These liposomes are beneficial in medical therapies because they possess distinctive characteristics. As conventional liposomes, they can encapsulate therapeutic molecules and transport them to the desired location, preventing direct contact between drug and blood.…”

Section: ■ Introductionmentioning

confidence: 99%

Small-Angle Neutron Scattering Study of Temperature-Induced Structural Changes in Liposomes

et al. 2019

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Liposomes of specific artificial phospholipids, such as Pad-PC-Pad and Rad-PC-Rad, are mechanically responsive. They can release encapsulated therapeutics via physical stimuli, as naturally present in blood flow of constricted vessel segments. The question is how these synthetic liposomes change their structure in the medically relevant temperature range from 22 to 42 °C. In the present study, small-angle neutron scattering (SANS) was employed to evaluate the temperatureinduced structural changes of selected artificial liposomes. For Rad-PC-Rad, Pad-Pad-PC, Sur-PC-Sur, and Sad-PC-Sad liposomes, the SANS data have remained constant because the phase transition temperatures are above 42 °C. For Pad-PC-Pad and Pes-PC-Pes liposomes, whose phase transitions are below 42 °C, the q-plots have revealed temperature-dependent structural changes. The average diameter of Pad-PC-Pad liposomes remained almost constant, whereas the eccentricity decreased by an order of magnitude. Related measurements using transmission electron microscopy at cryogenic temperatures, as well as dynamic light scattering before and after the heating cycles, underpin the fact that the non-spherical liposomes flatten out. The SANS data further indicated that, as a consequence of the thermal loop, the mean bilayer thickness increased by 20%, associated with the loss of lipid membrane interdigitation. Therefore, Pad-PC-Pad liposomes are unsuitable for local drug delivery in the atherosclerotic human blood vessel system. In contrast, Rad-PC-Rad liposomes are thermally stable for applications within the human body.

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Artificial Phospholipids and Their Vesicles

Cited by 16 publications

References 112 publications

Phospholipids: Identification and Implication in Muscle Pathophysiology

Phospholipids: Identification and Implication in Muscle Pathophysiology

Ultrasound‐Triggered Delivery of Iproplatin from Microbubble‐Conjugated Liposomes

Small-Angle Neutron Scattering Study of Temperature-Induced Structural Changes in Liposomes

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