Artificial pneumothorax suppresses postoperative inflammatory reaction in mediastinal tumor surgery

Abstract

Objective: The induction of artificial pneumothorax has many intraoperative advantages. However, few reports on the postoperative effects of artificial pneumothorax induction are available. In this study, we investigated the effect of artificial pneumothorax on postoperative clinical course in patients with mediastinal tumors. Methods:We retrospectively investigated the clinical courses of 89 patients who had undergone mediastinal tumor resection between January 2010 and December 2020.Sixty-five patients had undergone resection with artificial pneumothorax. Results:The tumor location significantly varied across patients. The proportion of patients in whom artificial pneumothorax was induced was higher among those having anterior mediastinal tumors. The number of ports and the total skin incision length were significantly higher in patients without artificial pneumothorax. The C-reactive protein level elevation on postoperative day2 and pleural effusion at 24 hours after surgery were significantly higher in patients without artificial pneumothorax. Furthermore, the albumin level reduction and hospital stay after surgery were significantly lower in patients with artificial pneumothorax. Multiple regression analysis showed that the use of artificial pneumothorax was an independent predictive factor of the C-reactive 4 protein level elevation on postoperative day 2 and pleural effusion at 24 hours after surgery. In patients without artificial pneumothorax, the operation time positively correlated with the C-reactive protein level (r=0.646, P<0.001).Conclusions: Artificial pneumothorax suppressed the postoperative inflammatory response, pleural effusion, and albumin reduction, and shortened the hospital stay in patients undergoing mediastinal tumor surgery.