Artocarpus altilis Extract Capsules Reduce Fasting Blood Glucose in Prediabetes

Sitorus, Junedi; Hadju, Veni; Jafar, Nurhaedar; Amiruddin, Ridwan; Syam, Aminuddin; Mahmudiono, Trias; Djabir, Yulia Yusrini; Moedjiono, Apik Indarty

doi:10.3889/oamjms.2022.7793

Cited by 3 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…15,33,48,55,60,61,62 Flavonoid merupakan salah satu senyawa yang dapat mengaktifkan reaksi oksidasi, yang dapat mengurangi bebas dan juga dapat meningkatkan fungsi sel pankreas dalam mensekresi hormon insulin, yang menurunkan kadar glukosa pada darah. 42…”

Section: Daun Sukununclassified

Potensi Tanaman Sukun (<i>Artocarpus altilis</i>) sebagai Agen Antiinflamasi dan Antidiabetes

Ni Gusti Ayu Diantari,

Debby Yunita,

Maria Aurelia Afila Tutonugi

et al. 2023

MEDICINUS

View full text Add to dashboard Cite

Latar belakang: Artocarpus altilis adalah tumbuhan yang setiap bagiannya berkhasiat untuk kesehatan. Di Indonesia, penyebaran tanaman sukun hanya ditemukan di tempat tertentu dan belum dibudidayakan, namun tanaman ini kaya akan senyawa flavonoid, tanin dan saponin yang berpotensi sebagai antidiabetes dan antiinflamasi. Diabetes tipe 2 adalah sekelompok gangguan metabolik yang ditandai dengan kondisi hiperglikemia dan dapat disebabkan karena kurangnya produksi maupun gangguan pada kerja insulin. Penyakit ini merupakan penyakit degeneratif yang menjadi masalah kesehatan di dunia. Tata laksana diabetes dilakukan dengan modifikasi gaya hidup dan dibantu dengan penggunaan obat-obatan antidiabetes maupun terapi insulin. Inflamasi merupakan reaksi lokal tubuh yang ditandai dengan gejala tertentu. Pengobatan inflamasi dengan menggunakan obat sintetik banyak menimbulkan efek samping. Tujuan: Review ini dibuat untuk memberikan informasi tentang aktivitas antidiabetes dan antiinflamasi pada tanaman sukun. Hasil: Senyawa dengan aktivitas antidiabetik dari tanaman sukun dihasilkan oleh bagian batang, daun, dan buah yang diperoleh dari serangkaian hasil pengujian yang dimulai dengan uji fitokimia, dilanjutkan dengan pengujian aktivitas antidiabetes secara in vivo, in vitro, dan uji kalorimetri AlCl, aktivitas antiinflamasi dihasilan oleh bagian daun dan buah yang dibuktikan dari hasil pengujian aktivitas antiinflamasi secara in vitro dan in vivo. Kesimpulan: Tanaman sukun berpotensi dikembangkan sebagai pengobatan alternatif untuk penyakit diabetes dan mengatasi inflamasi.

show abstract

Section: Daun Sukununclassified

Potensi Tanaman Sukun (<i>Artocarpus altilis</i>) sebagai Agen Antiinflamasi dan Antidiabetes

Ni Gusti Ayu Diantari,

Debby Yunita,

Maria Aurelia Afila Tutonugi

et al. 2023

MEDICINUS

View full text Add to dashboard Cite

show abstract

The Effect of Breadfruit Leaf Extract (Artocarpus Altilis) on Fasting Blood Sugar Levels among Diabetes Mellitus (DM) Type 2 Outpatient at Biru Public Health Center of Bone Regency, Indonesia

Ulandari

Hidayanty

Jafar

et al. 2023

Biomed. Pharmacol. J.

View full text Add to dashboard Cite

Diabetes is a disease that can reduce the quality of life of patients and lead to death. Based on Indonesian Basic Health research, the prevalence of diabetes mellitus has increased over several years. Breadfruit leaves contain antioxidant compounds that can lower blood sugar by inhibiting glucose transport in the gastrointestinal tract and stimulating insulin secretion in pancreatic beta cells. The study aimed to assess the effect of giving Breadfruit Leaf Extract on reducing Fasting Blood Sugar among type 2 Diabetes Mellitus Patients. The study used a quasi-experiment study with a randomized pretest-posttest, design with the control group. It involved 39 outpatients for type 2 diabetes mellitus at Biru Public Health Center of Bone Regency, who had suffered from Diabetes for 1-4 years. The sample was divided into 2 groups by simple random sampling, 19 respondents for the intervention group and 20 respondents for the control group. Data collected were the socio-demographic characteristics and fasting blood sugar levels. In the intervention group, breadfruit leaf capsules were given at a dose of 500 mg 1x1 for 21 days, while the control group was only given health education. The data were analyzed using the Chi-Square test, paired t-test, independent t-test, Wilcoxon Signed Rank Test, and Mann-Whitney. The majority of respondents aged 46-55 years were 53.8% in both groups, 74.4% were female, while the majority of BMI status had normal nutritional status as much as 41%. There was a change in FBS levels in the intervention group before (263.31 ± 134.43) and after (174.84 ± 84.99) intervention (p-value = 0.000). there was a change in FBS levels in the group before (181.35±91.36) and after (147.45 ±79.25) intervention (p-value = 0.001). it is known that there is a significant difference in changes in fasting blood sugar levels of patients with diabetes mellitus in the intervention group (-88.47±88.01) and the control group (-33.90±53.53) with (p-value = 0.024). The test results show that the content of flavonoids and other non-nutritive substances in breadfruit leaves has an effect on lowering the FBS of patients with diabetes mellitus and can be used as an alternative medicine in patients with diabetes mellitus.

show abstract

Effect of Breadfruit (Artocarpus Altilis) Leaf Extract on Blood Pressure in Obese Adults in Makassar, Indonesia

Jariah,

Jafar,

Bahar

et al. 2024

Biomed. Pharmacol. J.

View full text Add to dashboard Cite

Background: Obesity has become a global public health and nutrition problem. Obese people will have a variety of diseases, one of which is high blood pressure. Therefore, this study aims to determine the effect of breadfruit leaf extract on blood pressure in obese adults in Makassar City. Methods: An experimental study was conducted involving a double-blind, randomized controlled trial with pretest and posttest assessments, which included 36 obese respondents. The intervention group received breadfruit leaf extract in the methodology, while the control group received a placebo capsule. Blood pressure was monitored using a digital tension device. Data analysis was performed using SPSS 13, including paired tests, independent tests, Wilcoxon and Mann-Whitney tests. Results: Systolic and diastolic blood pressure were lower in the intervention control group before and after the intervention (p=0.015 and 0.018) with a difference (p=0.105) (p>0.05) of -3 systole and -3.5 diastole. Mean analysis for the intervention and control groups in systolic blood pressure revealed a p-value of 0.628, signifying no significant difference between the groups (p>0.05). While the control group's systolic and diastolic blood pressure before and after the intervention (p=0.007 and 0.003) (0.05) showed a difference (p=0.271) (p>0.05) with a decrease in the control group's systole -8.39 and diastole -3.22, there was no statistically significant difference between the two intervention and control groups—only a decrease. Conclusion: Giving breadfruit leaf extract capsules to the intervention group with obese respondents and high blood pressure showed a decrease in blood pressure after giving breadfruit leaf extract capsules. People with high blood pressure can consume breadfruit leaf decoction or extract.

show abstract

Artocarpus altilis Extract Capsules Reduce Fasting Blood Glucose in Prediabetes

Cited by 3 publications

References 22 publications

Potensi Tanaman Sukun (<i>Artocarpus altilis</i>) sebagai Agen Antiinflamasi dan Antidiabetes

Potensi Tanaman Sukun (<i>Artocarpus altilis</i>) sebagai Agen Antiinflamasi dan Antidiabetes

The Effect of Breadfruit Leaf Extract (Artocarpus Altilis) on Fasting Blood Sugar Levels among Diabetes Mellitus (DM) Type 2 Outpatient at Biru Public Health Center of Bone Regency, Indonesia

Effect of Breadfruit (Artocarpus Altilis) Leaf Extract on Blood Pressure in Obese Adults in Makassar, Indonesia

Contact Info

Product

Resources

About