Artrite reumatóide e doença cardiovascular na atualidade: o que sabemos sobre essa associação e o que podemos fazer pelo paciente?

Haddad, Marcela Filié; Ruppert, Aline Domingos Pinto; Soeiro, Alexandre de Matos; Serrano, Carlos

doi:10.11606/issn.1679-9836.v91i2p87-95

Cited by 1 publication

(3 citation statements)

References 28 publications

(134 reference statements)

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Section: Introductionmentioning

confidence: 99%

“…Patients with rheumatoid arthritis (RA) have life expectancy of 5 to 10 times lower than the general population due to increased cardiovascular risk, which is considered to be by 2 to 3 times higher [ 1 ]. The reason why these patients have early and accelerated atherosclerosis has been the subject of several studies [ 1 ]. Recently, it has been accepted that the chronic inflammatory process seen in RA is related to the genesis and development of atherosclerotic plaques [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…The reason why these patients have early and accelerated atherosclerosis has been the subject of several studies [ 1 ]. Recently, it has been accepted that the chronic inflammatory process seen in RA is related to the genesis and development of atherosclerotic plaques [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cardiovascular risk and mannose binding lectin in patients with rheumatoid arthritis from southern Brazil

Kahlow

Nisihara

Petisco

et al. 2018

IJC Heart & Vasculature

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BackgroundMannose binding lectin (MBL) appears to be involved in susceptibility to rheumatoid arthritis (RA), in the inflammatory process and in the genesis of atherosclerotic disease.ObjectiveTo study the association of MBL serum levels and its genotypic variation with carotid arteries intimal thickness (IMT) in RA patients from Southern Brazil.MethodsMBL serum levels, MBL2 genotyping and IMT were investigated in 90 RA patients along with their demographic, clinical and laboratory profile. MBL levels and MBL2 genotyping were evaluated in 90 healthy controls.ResultsA significant lower MBL serum concentration was observed in patients with RA in relation to controls (528 ng/mL vs 937.5 ng/mL, p = 0.05, respectively). The median IMT in RA patients was 0.59 mm (0.51 to 0.85 mm). There was no correlation between levels of MBL with disease activity, erythrocyte sedimentation rate, autoantibodies presence or IMT (p = NS). A weak and negative correlation was found between MBL and CRP levels (Rho = −0.24; p = 0.02;). The MBL2 variant at codon 54 (variant B) and HYPA haplotype were the most frequently observed in the RA sample (67.5% and 31.7%). MBL2 wild type (A/A) were associated with lower IMT when compared with heterozygotes (A/O; p = 0.04) and low producers (O/O; p = 0.05). In addition, high producers genotypes had lower levels of CRP when compared with medium (p = 0.04) or with low producers (p = 0.05).ConclusionRA patients had lower MBL levels than controls. MBL were negatively associated with CRP serum levels; low MBL genotypes producers increased thickness of the IMT than high producers.

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Section: Introductionmentioning

confidence: 99%