Artritis microcristalinas

Corral, S. Garrote; Mondragón, Sixto Zegarra; Astete, Carlos Guillén; Corral, F.J. Bachiller

doi:10.1016/j.med.2017.02.003

Cited by 2 publications

(5 citation statements)

References 39 publications

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“…Gout is among the most frequent inflammatory arthropathies, characterized by the deposition of monosodium urate (MSU) in the joints and periarticular and subcutaneous structures. Clinical symptoms occur with acute episodes of inflammation, which can lead to persistent clinical manifestations and even become chronic [ 1 , 2 ]. MSU deposition in the synovium leads to reactive oxygen species (ROS) release, resulting in cell death [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Osteostatin Mitigates Gouty Arthritis through the Inhibition of Caspase-1 Activation and Upregulation of Nrf2 Expression

Catalán,

Carceller,

Terencio

et al. 2024

IJMS

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Gouty arthritis results from monosodium urate (MSU) crystal deposition in joints, initiating (pro)-interleukin (IL)-1β maturation, inflammatory mediator release, and neutrophil infiltration, leading to joint swelling and pain. Parathyroid hormone-related protein (107–111) C-terminal peptide (osteostatin) has shown anti-inflammatory properties in osteoblasts and collagen-induced arthritis in mice, but its impact in gouty arthritis models remains unexplored. We investigated the effect of osteostatin on pyroptosis, inflammation, and oxidation in macrophages, as well as its role in the formation of calcium pyrophosphate dihydrate crystals and MSU-induced gouty arthritis in mice models. Osteostatin ameliorated pyroptosis induced by lipopolysaccharide and adenosine 5′-triphosphate (LPS + ATP) in mice peritoneal macrophages by reducing the expression of caspase-1, lactate dehydrogenase release, and IL-1β and IL-18 secretion. Additionally, IL-6 and tumor necrosis factor-α (TNF-α) were also decreased due to the reduced activation of the NF-κB pathway. Furthermore, osteostatin displayed antioxidant properties in LPS + ATP-stimulated macrophages, resulting in reduced production of mitochondrial and extracellular reactive oxygen species and enhanced Nrf2 translocation to the nuclei. In both models of gouty arthritis, osteostatin administration resulted in reduced pro-inflammatory cytokine production, decreased leukocyte migration, and reduced caspase-1 and NF-κB activation. These results highlight the potential of osteostatin as a therapeutic option for gouty arthritis.

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Section: Introductionmentioning

confidence: 99%

Osteostatin Mitigates Gouty Arthritis through the Inhibition of Caspase-1 Activation and Upregulation of Nrf2 Expression

Catalán,

Carceller,

Terencio

et al. 2024

IJMS

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“…In the first case, hospital admission and often surgical clearance are required, 1,2 and in the second case, management may be ambulatory even after an intra-articular steroid injection. 3 In fact, their discrimination is a challenge even for veteran clinicians. Clinical features of these 2 conditions are overlapping and in both the development of symptoms may follow an acute or hyperacute pattern.…”

mentioning

confidence: 99%

“…In fact, their discrimination is a challenge even for veteran clinicians. Clinical features of these 2 conditions are overlapping and in both the development of symptoms may follow an acute or hyperacute pattern 2,3 …”

mentioning

confidence: 99%

“…Clinical features of these 2 conditions are overlapping and in both the development of symptoms may follow an acute or hyperacute pattern. 2,3 In circumstances of usual clinical practice, the development of arthritis in a patient with a previous diagnosis of gout will intensely seduce the clinician to diagnose a new gout outbreak. This becomes even more feasible in emergency medicine or primary care settings, especially when the affected joint is not as accessible by puncture as a knee or elbow.…”

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confidence: 99%

“…However, the management of these 2 conditions is substantially different. In the first case, hospital admission and often surgical clearance are required, 1,2 and in the second case, management may be ambulatory even after an intra-articular steroid injection 3 . In fact, their discrimination is a challenge even for veteran clinicians.…”

mentioning

confidence: 99%

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