Aryltetralol and aryltetralone lignans from Holostylis reniformis

Silva, Tito da; Lopes, Lucia Maria Xavier

doi:10.1016/j.phytochem.2006.02.007

Cited by 32 publications

(46 citation statements)

References 8 publications

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“…Compound 6 has not yet been described in the literature. It was isolated from the active fraction 1, 5, and 6 (11:3:2) by semipreparative HPLC.…”

Section: Resultsmentioning

confidence: 99%

“…2). Moreover, the similarity between the CD curves of these lignans allowed us to determine the same absolute configuration for stereocenters on the B ring (5,6). Thus, the absolute configuration 7ЈR,8S,8ЈS was determined for lignan 6.…”

Section: Discussionmentioning

confidence: 99%

“…by Condorcet Aranha and Lindolpho Cappellari Jr. A voucher specimen (ESA88282) was deposited at the herbarium of the Escola Superior de Agricultura "Luiz de Queiroz", Piracicaba, SP, Brazil. The material was separated according to the plant parts, dried (ϳ45°C), and ground (4)(5)(6).…”

Section: Methodsmentioning

confidence: 99%

“…The plant material was extracted exhaustively at room temperature with hexane, acetone, and ethanol, successively, and the extracts were individually concentrated (4-6). The hexane extract (6.17 g) from the roots was fractionated by column chromatography (60.0 by 4.8 cm; silica gel 60 H; 151.0 g; hexane-ethyl acetate gradient, 95:5 to 100% ethyl acetate) to give 28 fractions (100 ml), as previously described (6). Several of these fractions were subjected to semipreparative HPLC (MeOH-H 2 O, 3:2).…”

Section: Methodsmentioning

confidence: 99%

“…1) isolated from extracts of this species by chromatography (column, thin-layer chromatography, and high-performance liquid chromatography [HPLC]) were then bioassayed in vitro for their antiplasmodial activities and toxicities. The structures of lignans 1 to 5 had been determined by spectroscopic methods and chemical transformations (5,6). Lignan 6 is reported here for the first time.…”

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confidence: 99%

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Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis

Andrade‐Neto

Silva

Lopes

et al. 2007

Antimicrob Agents Chemother

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Extracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum. The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7R,8S,8S)-3,4-methylenedioxy-4,5-dimethoxy-2,7-cyclolignan-7-one, were isolated and tested in vitro against P. falciparum. The three most active lignans showed 50% inhibitor concentrations of <0.32 M. An evaluation of minimum lethal dose (30%) values showed low toxicity for these lignans in a hepatic cell line (Hep G2A16). Therefore, these compounds are potential candidates for the development of antimalarial drugs.

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“…Compound 6 has not yet been described in the literature. It was isolated from the active fraction 1, 5, and 6 (11:3:2) by semipreparative HPLC.…”

Section: Resultsmentioning

confidence: 99%