Ascorbic acid alleviates oxidative stress and improves major salivary glands’ structure and function in diabetic rats: A histological and immunohistochemical study

Rasheed, Rabab Ahmed; Embaby, Azza; Elkhamisy, Fatma Alzahraa Abdelsalam; Mohamed, Mohamed Othman; Abbasi, Arshad Mehmood; Ghaly, Wael; Elshaer, Mohamed; Almaary, Khalid S.; Almoatasem, Mai A.M.

doi:10.1016/j.jksus.2022.102273

Cited by 1 publication

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References 28 publications

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“…In the end, sections were dehydrated, xylene cleared, and covered with glass covers to be examined microscopically. 43 , 45 …”

Section: Methodsmentioning

confidence: 99%

A multidisciplinary approach to the antioxidant and hepatoprotective activities of Arbutus pavarii Pampan fruit; in vitro and in Vivo biological evaluations, and in silico investigations

Elshibani,

Alamami,

Mohammed

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

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The Libyan Strawberry, Arbutus pavarii Pampan (ARB), is an endemic Jebel Akhdar plant used for traditional medicine. This study presents the antioxidant and hepatoprotective properties of ARB fruit-extract. ARB phytochemical analysis indicated the presence of 354.54 GAE and 36.2 RE of the phenolics and flavonoids. LC-MS analysis identified 35 compounds belonging to phenolic acids, procyanidins, and flavonoid glycosides. Gallic acid, procyanidin dimer B3, β-type procyanidin trimer C, and quercetin-3-O-glucoside were the major constituents of the plant extract. ARB administration to paracetamol (PAR)-intoxicated rats reduced serum ALT, AST, bilirubin, hepatic tissue MDA and proinflammatory markers; TNF-α and IL-6 with an increase in tissue GSH level and SOD activity. Histological and immunohistochemical studies revealed that ARB restored the liver histology and significantly reduced the tissue expression of caspase 3, IL-1B, and NF-KB in PAR-induced liver damage. Docking analysis disclosed good binding affinities of some compounds with XO, COX-1, 5-LOX, and PI3K.

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“…In the end, sections were dehydrated, xylene cleared, and covered with glass covers to be examined microscopically. 43 , 45 …”

Section: Methodsmentioning

confidence: 99%

A multidisciplinary approach to the antioxidant and hepatoprotective activities of Arbutus pavarii Pampan fruit; in vitro and in Vivo biological evaluations, and in silico investigations

Elshibani,

Alamami,

Mohammed

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

Ascorbic acid alleviates oxidative stress and improves major salivary glands’ structure and function in diabetic rats: A histological and immunohistochemical study

Cited by 1 publication

References 28 publications

A multidisciplinary approach to the antioxidant and hepatoprotective activities of Arbutus pavarii Pampan fruit; in vitro and in Vivo biological evaluations, and in silico investigations

A multidisciplinary approach to the antioxidant and hepatoprotective activities of Arbutus pavarii Pampan fruit; in vitro and in Vivo biological evaluations, and in silico investigations

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