Ascorbic Acid Prevents Vascular Endothelial Dysfunction Induced by Electronic Hookah (Waterpipe) Vaping

Rezk‐Hanna, Mary; Seals, Douglas R.; Rossman, Matthew J.; Gupta, Rajat; Nettle, Charlie O.; Means, Angelica; Dobrin, Daniel; Cheng, Chiao-Wei; Brecht, Mary‐Lynn; Mosenifar, Zab; Araujo, Jesús A.; Benowitz, Neal L.

doi:10.1161/jaha.120.019271

Cited by 5 publications

(2 citation statements)

References 56 publications

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“…36,37 Similar to e-cigarette vaping and despite the absence of tobacco combustion, flavored electronic hookah vaping has been shown to acutely impair endothelial function, likely mediated by oxidative stress. 38…”

Section: Prevalencementioning

confidence: 99%

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Martin,

Aday,

Almarzooq

et al. 2024

Circulation

476

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BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health. The AHA Heart Disease and Stroke Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, brain health, complications of pregnancy, kidney disease, congenital heart disease, rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary heart disease, cardiomyopathy, heart failure, valvular disease, venous thromboembolism, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). METHODS: The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2024 AHA Statistical Update is the product of a full year’s worth of effort in 2023 by dedicated volunteer clinicians and scientists, committed government professionals, and AHA staff members. The AHA strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year’s edition includes additional global data, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains. RESULTS: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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Section: Prevalencementioning

confidence: 99%

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Martin,

Aday,

Almarzooq

et al. 2024

Circulation

476

View full text Add to dashboard Cite

show abstract

“…72 E-hookah use has also been shown to have adverse effects on endothelial function, likely mediated by oxidative stress. 73 Higher arterial stiffness has been observed in ENDS users with an acute increase after use. 64,74 In a randomized study of healthy younger smokers, acute use of nicotine-containing ENDS products increased peripheral systolic blood pressure, heart rate, augmentation index, and pulse-wave velocity, but only when the e-liquid contained nicotine.…”

Section: Acute Health Effects and Toxicity Of E-cigarettes And Vaping...mentioning

confidence: 99%

Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products: A Scientific Statement From the American Heart Association

Rose¹,

Krishnan‐Sarin²,

Exil³

et al. 2023

Circulation

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Vaping and electronic cigarette (e-cigarette) use have grown exponentially in the past decade, particularly among youth and young adults. Cigarette smoking is a risk factor for both cardiovascular and pulmonary disease. Because of their more limited ingredients and the absence of combustion, e-cigarettes and vaping products are often touted as safer alternative and potential tobacco-cessation products. The outbreak of e-cigarette or vaping product use–associated lung injury in the United States in 2019, which led to >2800 hospitalizations, highlighted the risks of e-cigarettes and vaping products. Currently, all e-cigarettes are regulated as tobacco products and thus do not undergo the premarket animal and human safety studies required of a drug product or medical device. Because youth prevalence of e-cigarette and vaping product use was as high as 27.5% in high school students in 2019 in the United States, it is critical to assess the short-term and long-term health effects of these products, as well as the development of interventional and public health efforts to reduce youth use. The objectives of this scientific statement are (1) to describe and discuss e-cigarettes and vaping products use patterns among youth and adults; (2) to identify harmful and potentially harmful constituents in vaping aerosols; (3) to critically assess the molecular, animal, and clinical evidence on the acute and chronic cardiovascular and pulmonary risks of e-cigarette and vaping products use; (4) to describe the current evidence of e-cigarettes and vaping products as potential tobacco-cessation products; and (5) to summarize current public health and regulatory efforts of e-cigarettes and vaping products. It is timely, therefore, to review the short-term and especially the long-term implications of e-cigarettes and vaping products on cardiopulmonary health. Early molecular and clinical evidence suggests various acute physiological effects from electronic nicotine delivery systems, particularly those containing nicotine. Additional clinical and animal-exposure model research is critically needed as the use of these products continues to grow.

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Electronic hookah (waterpipe) vaping reduces vascular endothelial function: the role of nicotine

Rezk-Hanna,

Rossman,

Ludwig

et al. 2024

American Journal of Physiology-Heart and Circulatory Physiology

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Vaping has risen substantially in recent years, particularly among young adults. While e-hookah vaping acutely reduces endothelial function, the role of nicotine and the mechanisms by which it may impairs endothelial function remain understudied. In a randomized cross-over study, we investigated the acute effects of vaping e-hookah, with and without nicotine, as compared to sham on endothelial function assessed by brachial artery flow-mediated dilation (FMD), among 18 overtly healthy young adults. To determine the role of changes in circulating factors in plasma on endothelial cell function, human umbilical vein endothelial cells (HUVECs) were cultured with participants' plasma and acetylcholine-stimulated NO production and basal ROS bioactivity were assessed. E-hookah vaping with nicotine, which acutely increased heart rate (HR) 6±3 bpm and mean arterial pressure (MAP) 7±2 mm Hg (mean±SE; p<0.001), decreased endothelial-dependent FMD by 1.57±0.19%Δ (p=0.001), indicating impairment in endothelial function. Vaping e-hookah without nicotine, which mildly increased hemodynamics (p=ns), did not significantly impair endothelial function. No changes were observed after sham vaping. HUVECs cultured with participants' plasma after vs. before e-hookah vaping with nicotine, but not without nicotine or sham vaping, exhibited reductions in endothelial cell NO bioavailability and increases in ROS bioactivity (p<0.05). Plasma nicotine concentrations increased after vaping e-hookah with nicotine (6.7±1.8 ng/mL; p<0.001), whereas no changes were observed after e-hookah without nicotine or sham (p=ns). Acute e-hookah vaping induces endothelial dysfunction by impairing NO-bioavailability associated with increased ROS production, and these effects are attributable to nicotine, not to non-nicotine constituents, present in the flavored e-liquid.

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Ascorbic Acid Prevents Vascular Endothelial Dysfunction Induced by Electronic Hookah (Waterpipe) Vaping

Cited by 5 publications

References 56 publications

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products: A Scientific Statement From the American Heart Association

Electronic hookah (waterpipe) vaping reduces vascular endothelial function: the role of nicotine

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