Aseptic Meningitis Secondary to Antibiotic Therapy

Negron-Diaz, Juan; Klumpp, Linda C; Mayer, Cynthia A; Jordan, Jeffrey

doi:10.7759/cureus.14454

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2024

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Cited by 2 publications

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“…Although it is the most common antibiotic associated with DIAM, no pathophysiology has been identified. The leading theories include type III and type IV hypersensitivity reactions theorized to cause a small vessel vasculitis or delayed T-cell reaction leading to meningeal irritation [1,4,7]. This theory has been supported by reports of immune complexes identified in serum and CSF in patients with AM induced by a variety of antibiotics [6].…”

Section: Discussionmentioning

confidence: 96%

A Pediatric Case of Trimethoprim/ Sulfamethoxazole Associated Aseptic Meningitis

2024

Infect Dis Diag Treat

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Section: Discussionmentioning

confidence: 96%

A Pediatric Case of Trimethoprim/ Sulfamethoxazole Associated Aseptic Meningitis

2024

Infect Dis Diag Treat

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Acute aseptic meningitis temporally associated with trimethoprim and sulfamethoxazole: Systematic review

Bernasconi,

Milani,

De Felice

et al. 2024

Brit J Clinical Pharma

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Sulphonamides and trimethoprim, although generally well‐tolerated, have been temporally associated with aseptic meningitis. To address its presentation and outcome, a literature search was performed. We retained articles reporting patients with features of acute aseptic meningitis following intake of trimethoprim, sulfamethoxazole or sulfisoxazole. A cerebrospinal fluid investigation in ≥1 episode was a prerequisite for inclusion. Sixty articles reporting on 74 patients experiencing a total of 155 episodes were retained. Forty‐five (61%) patients had one or more recurrences. Median age at first episode was 43 (interquartile range [IQR] 23–61) years. Symptoms presented within 48 (IQR 6–168) hours of intake at the first episode and within 1.3 (IQR 1–5) hours at recurrences (p < .0001). Cerebrospinal fluid analysis revealed a predominantly neutrophilic (82%, IQR 65%–94%) pleocytosis (180, IQR 38–507 106 cells/L), without low glucose or high proteins. Recovery took place within 2 (IQR 1–3) days after stopping the suspected agent. All but one patient completely recovered.

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Aseptic Meningitis Secondary to Antibiotic Therapy

Abstract: Negron-Diaz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cited by 2 publications

References 8 publications

A Pediatric Case of Trimethoprim/ Sulfamethoxazole Associated Aseptic Meningitis

A Pediatric Case of Trimethoprim/ Sulfamethoxazole Associated Aseptic Meningitis

Acute aseptic meningitis temporally associated with trimethoprim and sulfamethoxazole: Systematic review

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