Asociación de variantes en genes de las proteínas desacoplantes con diabetes mellitus tipo 2 en una población del nordeste colombiano

Franco-Hincapié, Liliana; Duque, Constanza; Parra, María Victoria; Gallego, N.; Villegas, Alberto; Ruiz-Linares, Andrés; Bedoya, Gabriel

doi:10.7705/biomedica.v29i1.46

Cited by 9 publications

(4 citation statements)

References 51 publications

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“…This polymorphism (-55C/T) showed no allele or genotype association with obesity or overweight. Consistent with our results, there was no association between obesity and genotypes of UCP3 in Spain; however, a significant association was observed between obesity and the haplotype -866 A, 45D, -55T of UCP3 (50,52). In our study, the association of the C/C genotype of UCP3 with excess weight was only found in sedentary teenagers.…”

Section: Discussionsupporting

confidence: 81%

“…Regarding UCP3 rs1800849 (-55C/T), the frequency of the C allele was 0.88, which is consistent with the frequency reported by Franco, et al, for an adult population of the same region of our study (0.86) despite the difference in sample size, 994 (50). This polymorphism (-55C/T) showed no allele or genotype association with obesity or overweight.…”

Section: Discussionsupporting

confidence: 81%

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Variante en CAPN10 y factores ambientales muestran evidencia de asociación con exceso de peso en jóvenes de Medellín, Colombia

et al. 2014

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participated in the study design, the fieldwork, the genetic and environmental information analysis and the writing of the article. Rosa M. Uscátegui conducted the anthropometric component of the study. María V. Parra conducted the genetic component. Introduction: Obesity results from interaction between genetic and environmental risk factors. Objective: To evaluate the effect of three gene variants and environmental factors on obesity and overweight in young people aged 10 to 18 years in a Colombian population. Materials and methods:A total of 424 subjects were selected and separated into three groups for a cross-sectional study; 100 obese and 112 overweight subjects were matched with 212 normal-weight controls. Associations were evaluated between excess weight and three genetic polymorphisms (UCP3-rs1800849, FTO-rs17817449, and CAPN10-rs3842570), as well as the family history, the time spent watching television and playing video games, and the diet. Results: A family history of obesity, the time spent watching television and playing video games, the lack of breastfeeding, a low consumption of cereals, legumes, fruits, vegetables, and a high consumption of fast foods were characteristics typically found in obese individuals compared to controls. A significant association between genotype I/I (SNP19 of CAPN10) and excess weight was found even with an active lifestyle. In addition, significant associations between the C/C genotype of the UCP3 gene and the G/G and T/T genotypes of the FTO gene and excess weight were found only in young sedentary individuals. Conclusions:In this population, inadequate diet and sedentary lifestyle increased the risk of excess weight. Genotype I/I of SNP19 in CAPN10 was significantly associated with excess weight. In contrast, FTO and UCP3 variants exhibited effects only in sedentary environments.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 81%

Variante en CAPN10 y factores ambientales muestran evidencia de asociación con exceso de peso en jóvenes de Medellín, Colombia

et al. 2014

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“…In Chilean individuals, the polymorphism pro72Arg of the TP53 gene was associated with coronary disease in a study of cases and controls; however, this association is suggested to be confirmed with a population study 52 . Moreover, in a population from the Colombian northeast, variants of uncoupling proteins 1, 2, and 3 and their haplotypes conferred risk for T2DM 53 . In addition, studies indicate that the effect of polymorphisms on the risk of T2DM and CVD related to insulin resistance depends on the clinical characteristics of the individuals, including body weight and age of onset of the disease 54 .…”

Section: Insulin Resistance Central Focus Of Metabolic Deregulationmentioning

confidence: 97%

An approach to the etiology of metabolic syndrome

Múñoz¹,

Bedoya²,

Velásquez³

2013

Colomb Med

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Increased prevalence of obesity in the world, especially accumulation of abnormal amounts of visceral fat predisposes to insulina resistance, which is the central role of metabolic syndrome (MS). Obesity can deregulate the intracellular signaling of insulina due to the production of inflammatory substances, chemo attractant proteins, adipokines and molecules that trigger hormonal mediator potentials for destabilization of signal transduction, leading to metabolic disorders such as hyperglycemia, hypertension, and dyslipidemia. The complexity of the MS and of the genetic mechanisms involved in its etiology derives from the combination of variants on genes involved and environmental factors that predispose it. The purpose of this paper is to review the effects of obesity in molecular and biochemical responses that trigger insulin resistance and its relation to some candidate genes and the ancestral component of the population.

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“…La frecuencia relativa del alelo mutado en la población estudiada (0,231) coincide con la reportada por Mancini en sujetos obesos italianos siendo ligeramente inferior a la reportada en poblaciones como Dinamarca, Alemania y sujetos del noroeste colombiano (4,11,13).…”

Section: Discusionunclassified

Estudio de asociación del polimorfismo -866 G/A del gen UCP2 con obesidad en una población de Valledupar

Heredia¹,

Daza²,

Fernández³

2014

Rev. Cienc. Salud

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Obesity is a multifactorial disease that is related to lifestyles, and environmental and genetic factors. One of the candidate genes for obesity is the UCP2. Its polymorphism-866G/A was associated with obesity in some populations. However, conflicting results have been reported around the world, indicating the need for further investigations. Objective: To analyze the polymorphism-866G/A UCP2 gene associated with obesity in adults in the city of Valledupar. Materials and methods: We studied 103 overweight or obese individuals and 100 normal weight. The polymorphism of UCP2-866G/A was determined by PCR-RFLP. Anthropometric measures were also evaluated, lipoprotein profile and fasting glucose. Results: We found that the mutated allele and homozygous genotype were significantly more frequent in patients with BMI > 25 kg/m 2. [A: OR = 2.9 (95% CI= 1,765 to 4,751) and AA: OR= 5.8 (95% CI = 1,264 to 2,745)]. No significant differences were found between UCP2-866G/A and the clinical variables studied in obese individuals. However it is observed that subjects with mutated alleles and genotypes had higher triglycerides, glucose and ICC and lower average HDL cholesterol. Conclusions: mutation-866G/A UCP2 gene is associated with obesity in the population studied, and although it seems to influence the anthropometric and biochemical measures in obese subjects could be related to increased ICC, glucose and triglycerides and decreased HDL.

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Asociación de variantes en genes de las proteínas desacoplantes con diabetes mellitus tipo 2 en una población del nordeste colombiano

Cited by 9 publications

References 51 publications

Variante en CAPN10 y factores ambientales muestran evidencia de asociación con exceso de peso en jóvenes de Medellín, Colombia

Variante en CAPN10 y factores ambientales muestran evidencia de asociación con exceso de peso en jóvenes de Medellín, Colombia

An approach to the etiology of metabolic syndrome

Estudio de asociación del polimorfismo -866 G/A del gen UCP2 con obesidad en una población de Valledupar

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